A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells
S Koyanagi, Y Kuramoto, H Nakagawa, H Aramaki… - Cancer research, 2003 - AACR
Because angiogenesis is essential for tumor growth and metastasis, inhibition of angiogenesis
has emerged as a new therapy to treat cancers. Hypoxia-induced expression of vascular …
has emerged as a new therapy to treat cancers. Hypoxia-induced expression of vascular …
Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
S Hayashida, A Arimoto, Y Kuramoto, T Kozako… - Molecular and cellular …, 2010 - Springer
Calorie restriction (CR) extends lifespans in a wide variety of species. CR induces an
increase in the NAD + /NADH ratio in cells and results in activation of SIRT1, an NAD + -dependent …
increase in the NAD + /NADH ratio in cells and results in activation of SIRT1, an NAD + -dependent …
Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues
S Koyanagi, S Okazawa, Y Kuramoto… - Molecular …, 2006 - academic.oup.com
Although altered homeostatic regulation, including disturbance of 24-h rhythms, is often
observed in the patients undergoing glucocorticoid therapy, the mechanisms underlying the …
observed in the patients undergoing glucocorticoid therapy, the mechanisms underlying the …
Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system
S Soeda, S Koyanagi, Y Kuramoto… - Thrombosis and …, 2008 - thieme-connect.com
Plasminogen activator inhibitor-1 (PAI-1), a member of the ser-pin gene family, is the
primary inhibitor of urokinase-type and tissue-type PA s.PA I-1 plays an important role in the …
primary inhibitor of urokinase-type and tissue-type PA s.PA I-1 plays an important role in the …
24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins
H Nakagawa, S Koyanagi, T Takiguchi, Y Kuramoto… - Cancer research, 2004 - AACR
Methionine aminopeptidase2 (MetAP2) plays an important role in the growth of endothelial
cells during the tumor angiogenesis stage. Recently, we have clarified that mouse …
cells during the tumor angiogenesis stage. Recently, we have clarified that mouse …
Optimizing the dosing schedule of TNP-470 [O-(chloroacetyl-carbamoyl) fumagillol] enhances its antitumor and antiangiogenic efficacies
S Koyanagi, H Nakagawa, Y Kuramoto, S Ohdo… - … of Pharmacology and …, 2003 - ASPET
Many drugs vary in potency and/or toxicity according to the time of day when they are
administered. In this study, we investigated whether antitumor efficacy of angiogenesis inhibitor, …
administered. In this study, we investigated whether antitumor efficacy of angiogenesis inhibitor, …
Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice
S Hayashida, Y Kuramoto, S Koyanagi… - Chronobiology …, 2010 - Taylor & Francis
Acute thrombotic events frequently occur in the early morning among hyperlipidemic patients.
The activity of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of the fibrinolytic …
The activity of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of the fibrinolytic …
Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation
T Ochiai, Y Takenaka, Y Kuramoto, M Kasuya… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Prosaposin triggers G-protein-coupled receptor (GPCR)-mediated protein kinase B (Akt)/extracellular
signal-regulated kinase (ERK) phosphorylation cascades to exert its neurotrophic …
signal-regulated kinase (ERK) phosphorylation cascades to exert its neurotrophic …
[HTML][HTML] Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1α in human umbilical vein endothelial cells
T Kozako, N Matsumoto, Y Kuramoto, A Sakata… - FEBS letters, 2012 - Elsevier
Vasohibin is thought to be an important negative feedback regulator of angiogenesis that is
selectively induced in endothelial cells by VEGF. Here, we assessed the role of vasohibin on …
selectively induced in endothelial cells by VEGF. Here, we assessed the role of vasohibin on …
Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones
Y Kuramoto, K Hata, S Koyanagi, S Ohdo… - Biochemical …, 2006 - Elsevier
Because glucocorticoid hormones modulate various biological processes, the endogenous
rhythm of their secretion is thought to be an important factor affecting the efficacy and/or …
rhythm of their secretion is thought to be an important factor affecting the efficacy and/or …