User profiles for Yuri A. Kuryshev

Yuri Kuryshev

Charles River Cleveland, Inc.
Verified email at crl.com
Cited by 3488

[HTML][HTML] MICE models: superior to the HERG model in predicting Torsade de Pointes

J Kramer, CA Obejero-Paz, G Myatt, YA Kuryshev… - Scientific reports, 2013 - nature.com
Drug-induced block of the cardiac hERG (human Ether-ŕ-go-go-Related Gene) potassium
channel delays cardiac repolarization and increases the risk of Torsade de Pointes (TdP), a …

Mechanisms of arsenic-induced prolongation of cardiac repolarization

E Ficker, YA Kuryshev, AT Dennis, C Obejero-Paz… - Molecular …, 2004 - ASPET
Arsenic trioxide (As 2 O 3 ) produces dramatic remissions in patients with relapsed or refractory
acute promyelocytic leukemia. Its clinical use is burdened by QT prolongation, torsade …

Pentamidine-induced long QT syndrome and block of hERG trafficking

YA Kuryshev, E Ficker, L Wang, P Hawryluk… - … of Pharmacology and …, 2005 - ASPET
The diamidine pentamidine is used to treat leishmaniasis, trypanosomiasis, and Pneumocystis
carinii pneumonia. Treatment may be accompanied by prolongation of the QT interval of …

Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels

YA Kuryshev, AM Brown, L Wang, CR Benedict… - … of Pharmacology and …, 2000 - ASPET
Administration of the 5-hydroxytryptamine 3 receptor class of antiemetic agents has been
associated with prolongation in the QRS, JT, and QT intervals of the ECG. To explore the …

HERG-LiteŽ: A novel comprehensive high-throughput screen for drug-induced hERG risk

BA Wible, P Hawryluk, E Ficker, YA Kuryshev… - … of pharmacological and …, 2005 - Elsevier
INTRODUCTION: Direct block of I Kr by non-antiarrhythmic drugs (NARDs) is a major cause
of QT prolongation and torsades de pointes (TdP), and has made the hERG potassium …

Decreased sodium and increased transient outward potassium currents in iron-loaded cardiac myocytes: implications for the arrhythmogenesis of human siderotic …

YA Kuryshev, GM Brittenham, H Fujioka, P Kannan… - Circulation, 1999 - Am Heart Assoc
Background—Patients with chronic iron overload may develop a cardiomyopathy
manifested by ventricular arrhythmias and heart failure. We hypothesized that iron-loaded …

Alfuzosin delays cardiac repolarization by a novel mechanism

AE Lacerda, YA Kuryshev, Y Chen… - … of Pharmacology and …, 2008 - ASPET
The United States Food and Drug Administration (FDA) uses alfuzosin as an example of a
drug having QT risk in humans that was not detected in nonclinical studies. FDA approval …

KChAP as a chaperone for specific K+channels

YA Kuryshev, TI Gudz, AM Brown… - American Journal of …, 2000 - journals.physiology.org
The concept of chaperones for K + channels is new. Recently, we discovered a novel
molecular chaperone, KChAP, which increased total Kv2.1 protein and functional channels in …

[HTML][HTML] Cloning and expression of a novel K+ channel regulatory protein, KChAP

BA Wible, Q Yang, YA Kuryshev, EA Accili… - Journal of Biological …, 1998 - ASBMB
Voltage-gated K + (Kv) channels are important in the physiology of both excitable and
nonexcitable cells. The diversity in Kv currents is reflected in multiple Kv channel genes whose …

Pyrethroid neurotoxicity studies with bifenthrin indicate a mixed Type I/II mode of action

…, SF El‐Naggar, YA Kuryshev… - Pest management …, 2019 - Wiley Online Library
BACKGROUND Bifenthrin is usually considered a Type I pyrethroid, because it lacks an α‐CN
group present in Type II pyrethroids, but some previous studies suggest a mixed Type I/II …