PURPOSE: The only possibility of a surgical cure in patients with locally advanced primary
or recurrent rectal cancer would be an extended resection such as pelvic exenteration and …

Three agents, verapamil, cepharanthine, and 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl-5-(trans-4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-3-…

MRP has been identified as another multidrug‐resistance (MDR) gene and may be involved
in an alternative MDR mechanism in some solid tumors. We investigated the expression of …

Mutations of the p53 gene are the most common abnormalities in human cancer. In contrast
to mutant p53, wild-type (wt) p53 protein is present at low levels due to rapid degradation by …

Thyroid carcinoma accounts for the majority of deaths from endocrine cancers. Although
effective therapies exist for well differentiated tumors, the treatment options for poorly …

Human epidermoid KB cell lines resistant to high levels of adriamycin, C-A90, C-A120, C-A500,
and C-A1000, were isolated in selection medium containing increasing concentrations …

The mechanism of multidrug resistance protein (MRP)-mediated multidrug resistance (MDR)
is still unclear. MRP reportedly transports some GSH conjugates. Recently, we …

An active efflux pump forcis-diamminedichloroplatinum(II) (cisplatin) has been identified in
cisplatin-resistant KCP-4 cells isolated from human epidermoid carcinoma KB-3-1 cells. The …

Six cases of carcinosarcoma of the esophagus were studied clinicopathologically,
immunohistochemically and with DNA flow cytometry. Transitional areas with morphology …

The successful use of tissue‐ or tumor‐selective promoters in targeted gene therapy for cancer
depends on high and selective activity. Tg is a thyroid‐specific protein that is expressed …