β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action
J Xiang, M Ipek, V Suri, M Tam, Y Xing, N Huang… - Bioorganic & medicinal …, 2007 - Elsevier
The design, synthesis, and biological evaluation of β-keto sulfones as 11β-HSD1 inhibitors
and the mechanism of inhibition are described here. This class of compounds is not active …
and the mechanism of inhibition are described here. This class of compounds is not active …
In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell …
P Ye, Y Xing, Z Dai, AJ D'Ercole - Developmental Brain Research, 1996 - Elsevier
The in vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development have
been investigated in transgenic (Tg) mice (IGF-II/I Tg mice) in whom an IGF-II promoter-driven …
been investigated in transgenic (Tg) mice (IGF-II/I Tg mice) in whom an IGF-II promoter-driven …
Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
…, W Massefski, N Pan, Y Ge, M Tam, Y Xing… - Bioorganic & medicinal …, 2005 - Elsevier
The design, synthesis, and biological evaluation of arylsulfonamidooxazoles as 11β-HSD1
inhibitors and the serendipitous discovery of β-keto sulfones as potent 11β-HSD1 inhibitors …
inhibitors and the serendipitous discovery of β-keto sulfones as potent 11β-HSD1 inhibitors …
Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms
…, K Harding, L Kung, M Tam, L Stolz, Y Xing… - Molecular …, 2005 - ASPET
Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2
diabetes. In insulin-resistant rodent models, ertiprotafib and a close analog lowered both …
diabetes. In insulin-resistant rodent models, ertiprotafib and a close analog lowered both …
Efficacious 11β-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model
…, X Xu, X Tian, V Suri, S Hahm, Y Xing… - Journal of medicinal …, 2009 - ACS Publications
Cortisol and the glucocorticoid receptor signaling pathway have been implicated in the
development of diabetes and obesity. The reduction of cortisone to cortisol is catalyzed by 11β-…
development of diabetes and obesity. The reduction of cortisone to cortisol is catalyzed by 11β-…
[HTML][HTML] Small molecule ligands define a binding site on the immune regulatory protein B7. 1
DV Erbe, S Wang, Y Xing, JF Tobin - Journal of Biological Chemistry, 2002 - ASBMB
The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting
cells plays an important role in the activation of naive T cells. Consequently, agents that …
cells plays an important role in the activation of naive T cells. Consequently, agents that …
Human insulin-like growth factor-binding protein-1 (hIGFBP-1) in transgenic mice: characterization and insights into the regulation of IGFBP-1 expression
Z Dai, Y Xing, CM Boney, DR Clemmons… - …, 1994 - academic.oup.com
Three hemizygous transgenic (Tg) mouse lines were generated with a fusion gene composed
of the mouse metallothionein promoter (mMT-I) and a full-length human insulin-like growth …
of the mouse metallothionein promoter (mMT-I) and a full-length human insulin-like growth …
Piperazine sulfonamides as potent, selective, and orally available 11β-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced …
…, TS Mansour, X Xu, V Suri, M Tam, Y Xing… - Journal of medicinal …, 2008 - ACS Publications
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is the enzyme that converts cortisone
to cortisol. Evidence suggests that selective inhibition of 11β-HSD1 could treat diabetes …
to cortisol. Evidence suggests that selective inhibition of 11β-HSD1 could treat diabetes …
Measurement of real contact area for rough metal surfaces and the distinction of contribution from elasticity and plasticity
LT Li, XM Liang, YZ Xing, D Yan… - Journal of …, 2021 - asmedigitalcollection.asme.org
The measurement of the real contact area between rough surfaces is one of the most
challenging problems in contact mechanics and is of importance to understand some physical …
challenging problems in contact mechanics and is of importance to understand some physical …
Porous Gold Nanoshells on Functional NH2‐MOFs: Facile Synthesis and Designable Platforms for Cancer Multiple Therapy
AuroShell nanoparticles (sealed gold nanoshell on silica) are the only inorganic materials
that are approved for clinical trial for photothermal ablation of solid tumors. Based on that, …
that are approved for clinical trial for photothermal ablation of solid tumors. Based on that, …