β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action

J Xiang, M Ipek, V Suri, M Tam, Y Xing, N Huang… - Bioorganic & medicinal …, 2007 - Elsevier
The design, synthesis, and biological evaluation of β-keto sulfones as 11β-HSD1 inhibitors
and the mechanism of inhibition are described here. This class of compounds is not active …

In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell …

P Ye, Y Xing, Z Dai, AJ D'Ercole - Developmental Brain Research, 1996 - Elsevier
The in vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development have
been investigated in transgenic (Tg) mice (IGF-II/I Tg mice) in whom an IGF-II promoter-driven …

Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

…, W Massefski, N Pan, Y Ge, M Tam, Y Xing… - Bioorganic & medicinal …, 2005 - Elsevier
The design, synthesis, and biological evaluation of arylsulfonamidooxazoles as 11β-HSD1
inhibitors and the serendipitous discovery of β-keto sulfones as potent 11β-HSD1 inhibitors …

Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms

…, K Harding, L Kung, M Tam, L Stolz, Y Xing… - Molecular …, 2005 - ASPET
Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2
diabetes. In insulin-resistant rodent models, ertiprotafib and a close analog lowered both …

Efficacious 11β-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model

…, X Xu, X Tian, V Suri, S Hahm, Y Xing… - Journal of medicinal …, 2009 - ACS Publications
Cortisol and the glucocorticoid receptor signaling pathway have been implicated in the
development of diabetes and obesity. The reduction of cortisone to cortisol is catalyzed by 11β-…

[HTML][HTML] Small molecule ligands define a binding site on the immune regulatory protein B7. 1

DV Erbe, S Wang, Y Xing, JF Tobin - Journal of Biological Chemistry, 2002 - ASBMB
The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting
cells plays an important role in the activation of naive T cells. Consequently, agents that …

Human insulin-like growth factor-binding protein-1 (hIGFBP-1) in transgenic mice: characterization and insights into the regulation of IGFBP-1 expression

Z Dai, Y Xing, CM Boney, DR Clemmons… - …, 1994 - academic.oup.com
Three hemizygous transgenic (Tg) mouse lines were generated with a fusion gene composed
of the mouse metallothionein promoter (mMT-I) and a full-length human insulin-like growth …

Piperazine sulfonamides as potent, selective, and orally available 11β-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced …

…, TS Mansour, X Xu, V Suri, M Tam, Y Xing… - Journal of medicinal …, 2008 - ACS Publications
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is the enzyme that converts cortisone
to cortisol. Evidence suggests that selective inhibition of 11β-HSD1 could treat diabetes …

Measurement of real contact area for rough metal surfaces and the distinction of contribution from elasticity and plasticity

LT Li, XM Liang, YZ Xing, D Yan… - Journal of …, 2021 - asmedigitalcollection.asme.org
The measurement of the real contact area between rough surfaces is one of the most
challenging problems in contact mechanics and is of importance to understand some physical …

Porous Gold Nanoshells on Functional NH2‐MOFs: Facile Synthesis and Designable Platforms for Cancer Multiple Therapy

C Liu, L Luo, L Zeng, J Xing, Y Xia, S Sun, L Zhang… - Small, 2018 - Wiley Online Library
AuroShell nanoparticles (sealed gold nanoshell on silica) are the only inorganic materials
that are approved for clinical trial for photothermal ablation of solid tumors. Based on that, …