The multikinase inhibitor sorafenib is currently the treatment of reference for advanced
hepatocellular carcinoma (HCC). In our report, we examined the cytotoxic effects of sorafenib on …

Invadosomes are actin-based structures involved in extracellular matrix degradation.
Invadosomes is a term that includes podosomes and invadopodia, which decorate normal and …

Sorafenib is currently the medical treatment of reference for hepatocellular carcinoma (HCC),
but it is not known whether sorafenib is equally active in all HCC. Here, our aim was to …

Invadosomes are F-actin-based structures involved in extracellular matrix degradation, cell
invasion, and metastasis formation. Analyzing their proteome is crucial to decipher their …

Transforming growth factor-β1 (TGF-β1) is an important player in chronic liver diseases
inducing fibrogenesis and hepatocellular carcinoma (HCC) development. TGF-β1 promotes …

Proteins of the BCL2 family are key regulators of apoptosis. Their expression levels are
frequently altered in cancers, enabling tumor cells to survive. To gain insight into the …

Ferroptosis is a form of cell death that has recently been reported during exposure to erastin,
a chemical compound identified in a screen for molecules able to kill cancer cells carrying …

Unr (officially known as CSDE1) is a cytoplasmic RNA-binding protein with roles in the
regulation of mRNA stability and translation. In this study, we identified a novel function for Unr, …

Background Glioblastomas are heterogeneous tumors composed of a necrotic and tumor
core and an invasive periphery. Methods Here, we performed a proteomics analysis of laser-…

Cell adhesion, migration, and invasion are involved in many physiological and pathological
processes. For example, during metastasis formation, tumor cells have to cross anatomical …