Idiopathic Parkinson’s disease is characterized by a progressive loss of dopaminergic neurons,
but the exact disease aetiology remains largely unknown. To date, Parkinson’s disease …

Heterozygous variants in the glucocerebrosidase GBA1 gene are an increasingly recognized
risk factor for Parkinson’s disease (PD). Due to the GBAP1 pseudogene, which shares 96…

Objective The aim of the current study is to understand why some individuals avoid developing
Parkinson disease (PD) despite being at relatively high genetic risk, using the largest …

Background and Objectives Considerable heterogeneity exists in the literature concerning
genetic determinants of the age at onset (AAO) of Parkinson disease (PD), which could be …

Several phenotypic differences observed in Parkinson’s disease (PD) patients have been
linked to age at onset (AAO). We endeavoured to find out whether these differences are due to …

Objectives The LRRK2‐G2019S mutation is the most common cause of Parkinson's disease
(PD) in North Africa. G2019S‐PD has been described as similar to idiopathic with minor …

Parkinson’s disease (PD) etiology is associated with genetic and environmental factors that
lead to a loss of dopaminergic neurons. However, the functional interpretation of PD-…

Background Astrocytes have recently gained attention as key contributors to the pathogenesis
of neurodegenerative disorders including Parkinson’s disease. To investigate human …

Background In North African populations, G2019S mutation in LRRK2 gene, encoding for the
leucine-rich repeat kinase 2, is the most prevalent mutation linked to familial and sporadic …

Background: The hypothesis of body-first vs. brain-first subtype of PD has been proposed
with REM-Sleep behavior disorder (RBD) defining the former. The body-first PD presumes an …