- © 2016 Marshfield Clinic
Dietary Nitrate Acutely and Markedly Increased Exhaled Nitric Oxide in a Cystic Fibrosis Case
- Conor P. Kerley, BSc*,†⇑,
- Emma Kilbride, BSc*,
- Peter Greally, MD* and
- Basil Elnazir, MD*
- *Paediatric Respiratory Department, National Children’s Hospital, Dublin 24, Ireland
- †School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland
- Corresponding Author
: Conor P. Kerley, BSc, Paediatric Respiratory Department, National Children’s Hospital, Tallaght, Dublin 24 IRELAND, Email: conorkerley{at}gmail.com
Abstract
Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12-year-old, athletic boy with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo
