Comprehensive Catalog of Currently Documented Histone Modifications
- 1Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637
- 2Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
- Correspondence: yingming.zhao{at}uchicago.edu; bgarci{at}mail.med.upenn.edu
SUMMARY
Modern techniques in molecular biology, genomics, and mass spectrometry–based proteomics have identified a large number of novel histone posttranslational modifications (PTMs), many of whose functions are still under intense investigation. Here, we catalog histone PTMs under two classes: first, those whose functions have been fairly well studied and, second, those PTMs that have been more recently identified but whose functions remain unclear. We hope that this will be a useful resource for researchers from all biological or technical backgrounds, aiding in their chromatin and epigenetic pursuits.
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