Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Accelerated Communications

You have access
Thermoregulation-Independent Regulation of Sleep by Serotonin Revealed in Mice Defective in Serotonin Synthesis
Xian Zhang, Hongming Yan, Yanjia Luo, Zhili Huang and Yi Rao

Molecular Pharmacology April 10, 2018, mol.117.111229; DOI: https://doi.org/10.1124/mol.117.111229

Articles

You have access
Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes
Sophie J Bradley, Colin Molloy, Christoffer Bundgaard, Adrian J Mogg, Karen J Thompson, Louis Dwomoh, Helen E Sanger, Michael Crabtree, Simon M Brooke, Patrick M Sexton, Christian C Felder, Arthur Christopoulos, Lisa M Broad, Andrew B Tobin and Christopher J Langmead

Molecular Pharmacology April 25, 2018, mol.118.111872; DOI: https://doi.org/10.1124/mol.118.111872
You have access
Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors.
Emma T van der Westhuizen, Arthur Spathis, Elham Khajehali, Maneula Jorg, Shailesh N Mistry, Ben Capuano, Andrew B Tobin, Patrick M. Sexton, Peter J Scammells, Celine Valant and Arthur Christopoulos

Molecular Pharmacology April 24, 2018, mol.118.111633; DOI: https://doi.org/10.1124/mol.118.111633
You have access
A Transcriptional Regulatory Network Containing Nuclear Receptors and lncRNAs Controls Basal and Drug-Induced Expression of Cytochrome P450s in HepaRG Cells
Liming Chen, Yifan Bao, Stephanie C. Piekos, Kexin Zhu, Lirong Zhang and Xiao-bo Zhong

Molecular Pharmacology April 24, 2018, mol.118.112235; DOI: https://doi.org/10.1124/mol.118.112235
You have access
Restoration of physiological expression of 5-HT6 into the primary cilia of null mutant neurons lengthens both primary cilia and dendrites.
Atom J. Lesiak, Matthew Brodsky, Nathalie Cohenca, Alexandra G. Croicu and John F. Neumaier

Molecular Pharmacology April 20, 2018, mol.117.111583; DOI: https://doi.org/10.1124/mol.117.111583
You have access
Efficient high-throughput screening by ER Ca²⁺ measurement to identify inhibitors of ryanodine receptor Ca2+-release channels
Takashi Murayama, Nagomi Kurebayashi, Mari Ikegami-Yuasa, Shuichi Mori, Yukina Suzuki, Ryunosuke Akima, Haruo Ogawa, Junji Suzuki, Kazunori Kanemaru, Hideto Oyamada, Yuji Kiuchi, Masamitsu Iino, Hiroyuki Kagechika and Takashi Sakurai

Molecular Pharmacology April 19, 2018, mol.117.111468; DOI: https://doi.org/10.1124/mol.117.111468
You have access
Insulin receptor plasma membrane levels increased by the progesterone receptor membrane component 1
Kaia K Hampton, Hilaree Frazier, Katie Anderson, Olivier Thibault and Rolf J Craven

Molecular Pharmacology April 19, 2018, mol.117.110510; DOI: https://doi.org/10.1124/mol.117.110510
You have access
Cannabidiol inhibits endocannabinoid signaling in autaptic hippocampal neurons
Alex Straiker, Michaela Dvorakova, Anaelle Zimmowitch and Ken P. Mackie

Molecular Pharmacology April 18, 2018, mol.118.111864; DOI: https://doi.org/10.1124/mol.118.111864
You have access
Cysteine Scanning Mutagenesis of TM4b-4c Loop of Glutamate Transporter EAAT1 Reveals Three Conformationally Sensitive Residues
Wenlong Zhang, Xiuping Zhang and Shaogang Qu

Molecular Pharmacology April 13, 2018, mol.117.111245; DOI: https://doi.org/10.1124/mol.117.111245
You have access
Kir Channel Blockages by Proflavine Derivatives via Multiple Modes of Interaction
Atsushi Inanobe, Hideaki Itamochi and Yoshihisa Kurachi

Molecular Pharmacology April 12, 2018, mol.117.111377; DOI: https://doi.org/10.1124/mol.117.111377
You have access
Identification of global and ligand-specific calcium sensing receptor activation mechanisms
Andrew N Keller, Irina Kufareva, Tracy M Josephs, Jiayin Diao, Vyvyan T Mai, Arthur D Conigrave, Arthur Christopoulos, Karen J Gregory and Katie Leach

Molecular Pharmacology April 10, 2018, mol.118.112086; DOI: https://doi.org/10.1124/mol.118.112086
You have access
Methylindoles and methoxyindoles are agonists and antagonists of human aryl hydrocarbon receptor AhR
Martina Stepankova, Iveta Bartonkova, Eva Jiskrova, Radim Vrzal, Sridhar Mani, Sandhya Kortagere and Zdenek Dvorak

Molecular Pharmacology April 6, 2018, mol.118.112151; DOI: https://doi.org/10.1124/mol.118.112151
You have access
Leflunomide increases hepatic exposure to methotrexate and its metabolite by differentially regulating Mrp2/3/4 transporters via PPAR α activation
Le Wang, Leilei Ma, Yunfei Lin, Xing Liu, Ling Xiao, Yiting Zhang, Ye Xu, Hu Zhou and Guoyu Pan

Molecular Pharmacology April 4, 2018, mol.117.110593; DOI: https://doi.org/10.1124/mol.117.110593
You have access
Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains
Onofrio Laselva, Steven Molinski, Valeria Casavola and Christine E. Bear

Molecular Pharmacology April 4, 2018, mol.118.111799; DOI: https://doi.org/10.1124/mol.118.111799
You have access
Ionotropic and metabotropic mechanisms of allosteric modulation of α7 nicotinic receptor intracellular calcium
Justin R King, Aman Ullah, Ellen Bak, Saleet Jafri and Nadine Kabbani

Molecular Pharmacology March 27, 2018, mol.117.111401; DOI: https://doi.org/10.1124/mol.117.111401
You have access
GPR40-mediated Gα12 activation by allosteric full agonists highly efficacious at potentiating glucose-stimulated insulin secretion in human islets
Marie-Laure Rives, Brian Rady, Nadia Swanson, Shuyuan Zhao, Jenson Qi, Eric Arnoult, Ivona Bakaj, Arturo Mancini, Billy Breton, Paul S. Lee, Mark R Player and Alessandro Pocai

Molecular Pharmacology March 23, 2018, mol.117.111369; DOI: https://doi.org/10.1124/mol.117.111369
You have access
Inhibition of CD45 phosphatase activity induces cell cycle arrest and apoptosis of CD45+ lymphoid tumors ex vivo and in vivo
Michael Perron and H. Saragovi

Molecular Pharmacology March 19, 2018, mol.117.110908; DOI: https://doi.org/10.1124/mol.117.110908

Main menu

User menu

Search

Fast Forward

Accelerated Communications

Articles

Navigate

More Information

ASPET's Other Journals