Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Comparative docking to distinct G protein-coupled receptor conformations exclusively yields ligands with agonist efficacy
Magdalena Martina Scharf, Moritz Bunemann, Jillian Glenda Baker and Peter Kolb

Molecular Pharmacology October 17, 2019, mol.119.117515; DOI: https://doi.org/10.1124/mol.119.117515
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N-Terminal modification of Arg-Leu-Tyr-Glu, a VEGFR-2 antagonist, improves anti-tumor activity by increasing its stability against serum peptidases
Jung A Yun, Joohwan Kim, Yi Yong Baek, Wonjin Park, Minsik Park, Suji Kim, Taesam Kim, Seunghwan Choi, Dooil Jeoung, Hansoo Lee, Moo Ho Won, Ji Yoon Kim, Kwon Soo Ha, Young Guen Kwon and Young-Myeong Kim

Molecular Pharmacology October 8, 2019, mol.119.117234; DOI: https://doi.org/10.1124/mol.119.117234
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The natural compound Withaferin A covalently binds to Cys-239 of β-Tubulin to promote tubulin degradation
Jianhong Yang, Wei Yan, Yong Li, Lu Niu, Haoyu Ye and Lijuan Chen

Molecular Pharmacology October 4, 2019, mol.119.117812; DOI: https://doi.org/10.1124/mol.119.117812
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Mutational analysis and modeling of negative allosteric modulator binding sites in AMPA receptors
Charlotte Stenum-Berg, Maria Musgaard, Sergei Chavez-Abiega, Christine L Thisted, Lorenzo Barrella, Phillip C Biggin and Anders S Kristensen

Molecular Pharmacology October 3, 2019, mol.119.116871; DOI: https://doi.org/10.1124/mol.119.116871
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Conformational Changes in the 5-HT3A Receptor Extracellular Domain Measured by Voltage Clamp Fluorometry
Lachlan Munro, Lucy Kate Ladefoged, Vithushan Padmanathan, Signe Andersen, Birgit Schiott and Anders Skov Kristensen

Molecular Pharmacology October 3, 2019, mol.119.116657; DOI: https://doi.org/10.1124/mol.119.116657
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Homologous regulation of mu opioid receptor recycling by Gβγ, Protein Kinase C, and receptor phosphorylation
Jennifer M Kunselman, Amanda S Zajac, Zara Y Weinberg and Manojkumar A Puthenveedu

Molecular Pharmacology October 1, 2019, mol.119.117267; DOI: https://doi.org/10.1124/mol.119.117267
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Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines
Trista K. Hinz, Emily K. Kleczko, Katherine R. Singleton, Jacob Calhoun, Lindsay A. Marek, Jihye Kim, Aik-Choon Tan and Lynn E. Heasley

Molecular Pharmacology September 25, 2019, mol.119.117804; DOI: https://doi.org/10.1124/mol.119.117804
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Potential Regulation of UGT2B10 and UGT2B7 by miR-485-5p in human liver
Aimee K. Sutliff, Jian Shi, Christy J.W. Watson, Martina Hunt, Gang Chen, Hao-Jie Zhu and Philip Lazarus

Molecular Pharmacology September 25, 2019, mol.119.115881; DOI: https://doi.org/10.1124/mol.119.115881
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An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency For Regulators of G-protein Signaling (RGS) Proteins 4, 8, and 19
Vincent S Shaw, Mohammadjavad Mohammadi, Josiah A Quinn, Harish Vashisth and Richard R Neubig

Molecular Pharmacology September 22, 2019, mol.119.117176; DOI: https://doi.org/10.1124/mol.119.117176

Editorials

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From insight to modulation of CXCR4 and ACKR3 (CXCR7) function
Martine J Smit and Jacqueline E van Muilwijk-Koezen

Molecular Pharmacology October 17, 2019, mol.119.118364; DOI: https://doi.org/10.1124/mol.119.118364

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Molecular Pharmacology of Class F Receptor Activation
Pawel Kozielewicz, Ainoleena Turku and Gunnar Schulte

Molecular Pharmacology October 7, 2019, mol.119.117986; DOI: https://doi.org/10.1124/mol.119.117986
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Modulators of CXCR4 and CXCR7/ACKR3 function
Ilze Adlere, Birgit Caspar, Marta Arimont, Sebastian Dekkers, Kirsten Visser, Jeffrey Stuijt, Chris de Graaf, Michael Stocks, Barrie Kellam, Stephen Briddon, Maikel Wijtmans, Iwan de Esch, Stephen Hill and Rob Leurs

Molecular Pharmacology September 23, 2019, mol.119.117663; DOI: https://doi.org/10.1124/mol.119.117663
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Antibodies targeting chemokine receptors CXCR4 and ACKR3
Vladimir Bobkov, Marta Arimont, Aurelien Zarca, Timo De Groof, Bas van der Woning, Hans de Haard and Martine J. Smit

Molecular Pharmacology September 3, 2019, mol.119.116954; DOI: https://doi.org/10.1124/mol.119.116954
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Chemokine receptor crystal structures: what can be learnt from them?
Marta Arimont, Carsten Hoffmann, Chris de Graaf and Rob Leurs

Molecular Pharmacology July 2, 2019, mol.119.117168; DOI: https://doi.org/10.1124/mol.119.117168
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Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3)
Joyce Heuninck, Cristina Perpina Viciano, Ali Işbilir, Birgit Caspar, Davide Capoferri, Stephen J Briddon, Thierry Durroux, Stephen J Hill, Martin J Lohse, Graeme Milligan, Jean-Philippe Pin and Carsten Hoffmann

Molecular Pharmacology May 15, 2019, mol.118.115477; DOI: https://doi.org/10.1124/mol.118.115477
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Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.
Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf and Carmen Gallego

Molecular Pharmacology April 30, 2019, mol.118.115329; DOI: https://doi.org/10.1124/mol.118.115329
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CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status
Amos Fumagalli, Aurelien Zarca, Maria Neves, Birgit Caspar, Stephen J Hill, Federico Mayor, Martine J Smit and Philippe Marin

Molecular Pharmacology March 5, 2019, mol.118.115360; DOI: https://doi.org/10.1124/mol.118.115360
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The role of ACKR3 in breast, lung and brain cancer.
Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit and Federico Mayor

Molecular Pharmacology February 11, 2019, mol.118.115279; DOI: https://doi.org/10.1124/mol.118.115279

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