Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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A NanoBRET-based binding assay for Smoothened allows real time analysis of ligand binding and distinction of two binding sites for BODIPY-cyclopamine
Pawel Kozielewicz, Carl-Fredrik Bowin, Ainoleena Turku and Gunnar Schulte

Molecular Pharmacology November 9, 2019, mol.119.118158; DOI: https://doi.org/10.1124/mol.119.118158
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Cellular pharmacodynamics of a novel pyrrolo[3,2-d]pyrimidine inhibitor targeting mitochondrial and cytosolic one-carbon metabolism
Aamod S. Dekhne, Chengwen Ning, Md. Junayed Nayeen, Khushbu Shah, Hasini Kalpage, Josphephine Fruhauf, Adrianne Wallace-Povirk, Carrie O'Connor, Zhanjun Hou, Seongho Kim, Maik Huttemann, Aleem Gangjee and Larry H. Matherly

Molecular Pharmacology November 9, 2019, mol.119.117937; DOI: https://doi.org/10.1124/mol.119.117937
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Evaluation of operational models of agonism and allosterism at receptors with multiple orthosteric binding sites
Karen J. Gregory, Jesus Giraldo, Jiayin Daio, Arthur Christopoulos and Katie Leach

Molecular Pharmacology November 8, 2019, mol.119.118091; DOI: https://doi.org/10.1124/mol.119.118091
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Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by Gs and Gi/o Proteins
Susanne Neumann, Sarah S. Malik, Bernice Marcus-Samuels, Elena Eliseeva, Daesong Jang, Joanna Klubo-Gwiezdzinska, Christine C. Krieger and Marvin C. Gershengorn

Molecular Pharmacology November 8, 2019, mol.119.117382; DOI: https://doi.org/10.1124/mol.119.117382
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Loss-of-function mutations in human RGS2 differentially regulate pharmacological reactivity of resistance vasculature
Hoa T.N. Phan, William F. Jackson, Vincent Shaw, Stephanie W Watts and Richard R. Neubig

Molecular Pharmacology October 23, 2019, mol.119.116822; DOI: https://doi.org/10.1124/mol.119.116822
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Comparative docking to distinct G protein-coupled receptor conformations exclusively yields ligands with agonist efficacy
Magdalena Martina Scharf, Moritz Bunemann, Jillian Glenda Baker and Peter Kolb

Molecular Pharmacology October 17, 2019, mol.119.117515; DOI: https://doi.org/10.1124/mol.119.117515
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Mutational analysis and modeling of negative allosteric modulator binding sites in AMPA receptors
Charlotte Stenum-Berg, Maria Musgaard, Sergei Chavez-Abiega, Christine L Thisted, Lorenzo Barrella, Phillip C Biggin and Anders S Kristensen

Molecular Pharmacology October 3, 2019, mol.119.116871; DOI: https://doi.org/10.1124/mol.119.116871
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Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines
Trista K. Hinz, Emily K. Kleczko, Katherine R. Singleton, Jacob Calhoun, Lindsay A. Marek, Jihye Kim, Aik-Choon Tan and Lynn E. Heasley

Molecular Pharmacology September 25, 2019, mol.119.117804; DOI: https://doi.org/10.1124/mol.119.117804

Editorials

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From insight to modulation of CXCR4 and ACKR3 (CXCR7) function
Martine J Smit and Jacqueline E van Muilwijk-Koezen

Molecular Pharmacology October 17, 2019, mol.119.118364; DOI: https://doi.org/10.1124/mol.119.118364

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Molecular Pharmacology of Class F Receptor Activation
Pawel Kozielewicz, Ainoleena Turku and Gunnar Schulte

Molecular Pharmacology October 7, 2019, mol.119.117986; DOI: https://doi.org/10.1124/mol.119.117986
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Modulators of CXCR4 and CXCR7/ACKR3 function
Ilze Adlere, Birgit Caspar, Marta Arimont, Sebastian Dekkers, Kirsten Visser, Jeffrey Stuijt, Chris de Graaf, Michael Stocks, Barrie Kellam, Stephen Briddon, Maikel Wijtmans, Iwan de Esch, Stephen Hill and Rob Leurs

Molecular Pharmacology September 23, 2019, mol.119.117663; DOI: https://doi.org/10.1124/mol.119.117663
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Antibodies targeting chemokine receptors CXCR4 and ACKR3
Vladimir Bobkov, Marta Arimont, Aurelien Zarca, Timo De Groof, Bas van der Woning, Hans de Haard and Martine J. Smit

Molecular Pharmacology September 3, 2019, mol.119.116954; DOI: https://doi.org/10.1124/mol.119.116954
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Chemokine receptor crystal structures: what can be learnt from them?
Marta Arimont, Carsten Hoffmann, Chris de Graaf and Rob Leurs

Molecular Pharmacology July 2, 2019, mol.119.117168; DOI: https://doi.org/10.1124/mol.119.117168
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Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3)
Joyce Heuninck, Cristina Perpina Viciano, Ali Işbilir, Birgit Caspar, Davide Capoferri, Stephen J Briddon, Thierry Durroux, Stephen J Hill, Martin J Lohse, Graeme Milligan, Jean-Philippe Pin and Carsten Hoffmann

Molecular Pharmacology May 15, 2019, mol.118.115477; DOI: https://doi.org/10.1124/mol.118.115477
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Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.
Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf and Carmen Gallego

Molecular Pharmacology April 30, 2019, mol.118.115329; DOI: https://doi.org/10.1124/mol.118.115329
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CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status
Amos Fumagalli, Aurelien Zarca, Maria Neves, Birgit Caspar, Stephen J Hill, Federico Mayor, Martine J Smit and Philippe Marin

Molecular Pharmacology March 5, 2019, mol.118.115360; DOI: https://doi.org/10.1124/mol.118.115360
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The role of ACKR3 in breast, lung and brain cancer.
Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit and Federico Mayor

Molecular Pharmacology February 11, 2019, mol.118.115279; DOI: https://doi.org/10.1124/mol.118.115279

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