Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

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A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in its Interactions with α7 and α4β2 Nicotinic Acetylcholine Receptors
Hong Xing, Kristin W Andrud, Ferenc Soti, Anne Rouchaud, Stephan C Jahn, Ziang Lu, Yeh-hyon Cho, Sophia Habibi, Patrick Corsino, Svetoslav Slavov, James R Rocca, Jon S Lindstrom, Ron J Lukas and William Kem

Molecular Pharmacology May 30, 2020, mol.119.118786; DOI: https://doi.org/10.1124/mol.119.118786
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Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4.
Cristina Perpina-Viciano, Ali Isbilir, Aurelien Zarca, Birgit Caspar, Laura E. Kilpatrick, Stephen J. Hill, Martine J. Smit, Martin J. Lohse and Carsten Hoffmann

Molecular Pharmacology May 30, 2020, mol.119.118448; DOI: https://doi.org/10.1124/mol.119.118448
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The phosphodiesterase inhibitor IBMX blocks the potassium channel THIK-1 from the extracellular side
Xinle Zou, Linus J. Conrad, Kristin Koschinski, Günter Schlichthörl, Regina Preisig-Müller, Eugen Netz, Jens Krüger, Jürgen Daut and Vijay Renigunta

Molecular Pharmacology May 28, 2020, MOLPHARM-AR-2020-000011; DOI: https://doi.org/10.1124/molpharm.120.000011
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5-hydroxymethyl-furfural and structurally related compounds block the ion conductance in human aquaporin-1 channels, and slow cancer cell migration and invasion
Pak Hin Chow, Mohamad Kourghi, Jinxin V Pei, Saeed Nourmohammadi and Andrea J Yool

Molecular Pharmacology May 20, 2020, mol.119.119172; DOI: https://doi.org/10.1124/mol.119.119172
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Chronic treatment with morphine disrupts acute kinase-dependent desensitization of GPCRs
Emily R Leff, Seksiri Arttamangkul and John T Williams

Molecular Pharmacology May 3, 2020, mol.119.119362; DOI: https://doi.org/10.1124/mol.119.119362
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The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells.
Philipp Y. Maximov, Balkees Abderrahman, Yousef M. Hawsawi, Yue Chen, Charles E. Foulds, Antrix Jain, Anna Malovannaya, Ping Fan, Ramona F. Curpan, Ross Han, Sean W. Fanning, Bradley M. Broom, Daniela M. Quintana Rincon, Jeffery A. Greenland, Geoffrey L. Greene and V. Craig Jordan

Molecular Pharmacology May 3, 2020, mol.120.119776; DOI: https://doi.org/10.1124/mol.120.119776
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Small-molecule ligands that bind the RET receptor activate neuroprotective signals independent of but modulated by co-receptor GFRα1
Sean Jmaeff, Yulia Sidorova, Hayley Lippiatt, Pablo F. Barcelona, Hinyu Nedev, Lucia M. Saragovi, Mark A. Hancock, Mart Saarma and H. Uri Saragovi

Molecular Pharmacology May 3, 2020, mol.119.118950; DOI: https://doi.org/10.1124/mol.119.118950
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TMEM16A Ca²⁺-activated Cl^- channel regulates the proliferation and migration of brain capillary endothelial cells
Takahisa Suzuki, Miki Yasumoto, Yoshiaki Suzuki, Kiyofumi Asai, Yuji Imaizumi and Hisao Yamamura

Molecular Pharmacology May 1, 2020, mol.119.118844; DOI: https://doi.org/10.1124/mol.119.118844
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Detailed in vitro pharmacological characterization of clinically tested negative allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)
Angela Arsova, Thor C Møller, Line Vedel, Jakob L Hansen, Simon R Foster, Karen J Gregory and Hans Bräuner-Osborne

Molecular Pharmacology May 1, 2020, mol.119.119032; DOI: https://doi.org/10.1124/mol.119.119032
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Fentanyl-induced block of hERG channels is exacerbated by hypoxia, hypokalemia, alkalosis, and the presence of hERG1b
Jared N. Tschirhart and Shetuan Zhang

Molecular Pharmacology April 22, 2020, mol.119.119271; DOI: https://doi.org/10.1124/mol.119.119271

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Regulators of G protein signaling in analgesia and addiction
Farhana Sakloth, Claire Polizu, Feodora Bertherat and Venetia Zachariou

Molecular Pharmacology May 30, 2020, mol.119.119206; DOI: https://doi.org/10.1124/mol.119.119206
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Inhibition of Brain EGFR Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries
Omid Tavassoly, Takashi Sato and Iman Tavassoly

Molecular Pharmacology April 29, 2020, mol.120.119909; DOI: https://doi.org/10.1124/mol.120.119909
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Targeting ACE2/Angiotensin-(1-7)/Mas Receptor Axis in the Vascular Progenitor Cells for Cardiovascular Diseases
Yagna PR Jarajapu

Molecular Pharmacology April 22, 2020, mol.119.117580; DOI: https://doi.org/10.1124/mol.119.117580
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Opioid pharmacology under the microscope
Damien Jullié, Arisbel B Gondin, Mark E Von Zastrow and Meritxell Canals

Molecular Pharmacology April 10, 2020, mol.119.119321; DOI: https://doi.org/10.1124/mol.119.119321
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Phosphoproteomic Identification of Vasopressin/cAMP/PKA-Dependent Signaling in Kidney
Karim Salhadar, Allanah Matthews, Viswanathan Raghuram, Kavee Limbutara, Chin-Rang Yang, Arnab Datta, Chung-Lin Chou and Mark A. Knepper

Molecular Pharmacology April 3, 2020, mol.120.119602; DOI: https://doi.org/10.1124/mol.120.119602
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A concise review of concepts in opioid pharmacology up to the discovery of endogenous opioids
Brian M. Cox

Molecular Pharmacology March 31, 2020, mol.120.119420; DOI: https://doi.org/10.1124/mol.120.119420
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Recent progress in opioid research from an electrophysiological perspective
William T Birdsong and John T. Williams

Molecular Pharmacology March 20, 2020, mol.119.119040; DOI: https://doi.org/10.1124/mol.119.119040
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Bidirectional relationship between opioids and disrupted sleep: putative mechanisms
D. Eacret, S. C. Veasey and J. A. Blendy

Molecular Pharmacology March 20, 2020, mol.119.119107; DOI: https://doi.org/10.1124/mol.119.119107
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Defining a cellular map of cAMP nanodomains
Katharina Schleicher and Manuela Zaccolo

Molecular Pharmacology February 28, 2020, mol.119.118869; DOI: https://doi.org/10.1124/mol.119.118869
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RGS proteins as critical regulators of motor function and their implications in Parkinson's disease
Katelin E Ahlers-Dannen, Mackenzie M. Spicer and Rory A. Fisher

Molecular Pharmacology February 3, 2020, mol.119.118836; DOI: https://doi.org/10.1124/mol.119.118836

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