Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Dietary caffeine synergizes adverse peripheral and central responses to anesthesia in malignant hyperthermia susceptible mice
Monica Aleman, Rui Zhang, Wei Feng, Lihong Qi, Jose Lopez, Chelsea Crowe, Yao Dong, Gennady Cherednichenko and Isaac N. Pessah

Molecular Pharmacology August 6, 2020, mol.120.119412; DOI: https://doi.org/10.1124/mol.120.119412
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A truncated six transmembrane splice variant MOR-1G enhances expression of the full-length seven transmembrane mu opioid receptor through heterodimerization
Tiffany Zhang, Jin Xu and Ying-Xian Pan

Molecular Pharmacology August 1, 2020, mol.120.119453; DOI: https://doi.org/10.1124/mol.120.119453
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Enhancement of muscimol binding and gating by allosteric modulators of the GABA_A receptor: relating occupancy to state functions
Gustav Akk, Allison L. Germann, Yusuke Sugasawa, Spencer R. Pierce, Alex S. Evers and Joseph Henry Steinbach

Molecular Pharmacology July 28, 2020, MOLPHARM-AR-2020-000066; DOI: https://doi.org/10.1124/molpharm.120.000066
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Spinal opioid tolerance depends upon platelet-derived growth factor receptor-β signaling, not mu-opioid receptor internalization
Stephanie Puig, Katherine E Barker, Shelby R Szott, Peter T Kann, Jeffrey S Morris and Howard B Gutstein

Molecular Pharmacology July 28, 2020, mol.120.119552; DOI: https://doi.org/10.1124/mol.120.119552
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Unique Pharmacological Properties of the Kappa Opioid Receptor Signaling Through Gαz as Shown with BRET
Miriam E. Barnett, Brian I. Knapp and Jean M Bidlack

Molecular Pharmacology July 27, 2020, mol.120.119404; DOI: https://doi.org/10.1124/mol.120.119404
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Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives
Lu Wenchi Corrie, Clare Stokes, Jenny L. Wilkerson, F. Ivy Carroll, Lance R. McMahon and Roger L. Papke

Molecular Pharmacology July 20, 2020, MOLPHARM-AR-2020-000037; DOI: https://doi.org/10.1124/molpharm.120.000037
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Differing activity profiles of the stereoisomers of 2,3,5,6TMP-TQS, a putative silent allosteric modulator of α7nAChR
Roger L Papke, Sumanta Garai, Clare Stokes, Nicole A Horenstein, Arthur D Zimmerman, Khalil A Abboud and Ganesh A Thakur

Molecular Pharmacology July 20, 2020, mol.120.119958; DOI: https://doi.org/10.1124/mol.120.119958
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Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of µ-Opioid Receptor
Abhijeet Kapoor, Davide Provasi and Marta Filizola

Molecular Pharmacology July 17, 2020, mol.119.119339; DOI: https://doi.org/10.1124/mol.119.119339
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Analysis of modulation of the ρ1 GABAA receptor by combinations of inhibitory and potentiating neurosteroids reveals shared and distinct binding sites
Allison L. Germann, David E. Reichert, Ariel B. Burbridge, Spencer R. Pierce, Alex S. Evers, Joseph H. Steinbach and Gustav Akk

Molecular Pharmacology July 16, 2020, mol.120.119842; DOI: https://doi.org/10.1124/mol.120.119842
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Functional impact of the G279S substitution in the adenosine A1-receptor (A1R-G279S), a mutation associated with Parkinson's disease
Shahrooz Nasrollahi-Shirazi, Daniel Szöllösi, Qiong Yang, Edin Muratspahic, Ali El-kasaby, Sonja Sucic, Thomas Stockner, Christian Nanoff and Michael Freissmuth

Molecular Pharmacology July 8, 2020, MOLPHARM-AR-2020-000003; DOI: https://doi.org/10.1124/molpharm.120.000003
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Tyrosine nitration contributes to nitric oxide-stimulated degradation of CYP2B6
Choon-myung Lee, Ross Wilderman, Ji Won Park, T.J. Murphy and Edward T. Morgan

Molecular Pharmacology July 3, 2020, MOLPHARM-AR-2020-000020; DOI: https://doi.org/10.1124/molpharm.120.000020
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Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala
Gabrielle C Gregoriou, Sahil D Patel, Bryony L Winters and Elena E Bagley

Molecular Pharmacology June 30, 2020, mol.119.119370; DOI: https://doi.org/10.1124/mol.119.119370
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Hsp70:CHIP ubiquitinates dysfunctional but not native neuronal NO synthase
Amanda K Davis, Natalie F. McMyn, Miranda Lau, Yoshihiro Morishima and Yoichi Osawa

Molecular Pharmacology June 26, 2020, mol.120.119990; DOI: https://doi.org/10.1124/mol.120.119990
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OATP-mediated hepatic uptake of glucuronide metabolites of androgens
Cindy Yanfei Li, Anshul Gupta, Zsuzsanna Gáborik, Emese Kis and Bhagwat Prasad

Molecular Pharmacology June 25, 2020, mol.120.119891; DOI: https://doi.org/10.1124/mol.120.119891
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The phosphodiesterase inhibitor IBMX blocks the potassium channel THIK-1 from the extracellular side
Xinle Zou, Linus J. Conrad, Kristin Koschinski, Günter Schlichthörl, Regina Preisig-Müller, Eugen Netz, Jens Krüger, Jürgen Daut and Vijay Renigunta

Molecular Pharmacology May 28, 2020, MOLPHARM-AR-2020-000011; DOI: https://doi.org/10.1124/molpharm.120.000011
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Chronic treatment with morphine disrupts acute kinase-dependent desensitization of GPCRs
Emily R Leff, Seksiri Arttamangkul and John T Williams

Molecular Pharmacology May 3, 2020, mol.119.119362; DOI: https://doi.org/10.1124/mol.119.119362
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Fentanyl-induced block of hERG channels is exacerbated by hypoxia, hypokalemia, alkalosis, and the presence of hERG1b
Jared N. Tschirhart and Shetuan Zhang

Molecular Pharmacology April 22, 2020, mol.119.119271; DOI: https://doi.org/10.1124/mol.119.119271

Editorials

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Emerging Concepts. New Article Category in Molecular Pharmacology
David A. Gewirtz

Molecular Pharmacology August 6, 2020, MOLPHARM-ED-2020-000133; DOI: https://doi.org/10.1124/molpharm.120.000133

Emerging Concepts

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WEAK MICROBIAL METABOLITES: A TREASURE TROVE FOR USING BIOMIMICRY TO DISCOVER AND OPTIMIZE DRUGS
Zdenek Dvorak, Max Klapholz, Thomas P. Burris, Benjamin P Willing, Antimo Gioiello, Roberto Pellicciari, Francesco Galli, John March, Ryan B Sartor, Chang Kim, Maayan Levy, Sridhar Mani and Stephen J O'Keefe

Molecular Pharmacology August 6, 2020, MOLPHARM-AR-2020-000035; DOI: https://doi.org/10.1124/molpharm.120.000035

Letters to the Editor

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A Comment on "Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk."
Robert C. Speth

Molecular Pharmacology August 6, 2020, MOLPHARM-LTR-2020-000049; DOI: https://doi.org/10.1124/molpharm.120.000049

Minireview

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Pain, Motivation, Migraine and the Microbiome: New Frontiers for Opioid systems and Disease
Kyle E Parker, Elizabeth Sugiarto, Anna MW Taylor, Amynah Pradhan and Ream Al-Hasani

Molecular Pharmacology July 27, 2020, mol.120.119438; DOI: https://doi.org/10.1124/mol.120.119438
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Intrinsic efficacy of opioid ligands and its importance for apparent bias, operational analysis and therapeutic window
Alexander Gillis, Varun Sreenivasan and Macdonald J Christie

Molecular Pharmacology July 14, 2020, mol.119.119214; DOI: https://doi.org/10.1124/mol.119.119214
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Targeting VGLUT Machinery: Implications on mGluR5 Signaling and Behavior
Karim S. Ibrahim, Khaled S. Abd-Elrahman, Salah El Mestikawy and Stephen SG Ferguson

Molecular Pharmacology July 13, 2020, MOLPHARM-MR-2020-000089; DOI: https://doi.org/10.1124/molpharm.120.000089
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Regulators of G protein signaling in analgesia and addiction
Farhana Sakloth, Claire Polizu, Feodora Bertherat and Venetia Zachariou

Molecular Pharmacology May 30, 2020, mol.119.119206; DOI: https://doi.org/10.1124/mol.119.119206
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Targeting ACE2/Angiotensin-(1-7)/Mas Receptor Axis in the Vascular Progenitor Cells for Cardiovascular Diseases
Yagna PR Jarajapu

Molecular Pharmacology April 22, 2020, mol.119.117580; DOI: https://doi.org/10.1124/mol.119.117580
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Opioid pharmacology under the microscope
Damien Jullié, Arisbel B Gondin, Mark E Von Zastrow and Meritxell Canals

Molecular Pharmacology April 10, 2020, mol.119.119321; DOI: https://doi.org/10.1124/mol.119.119321
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Phosphoproteomic Identification of Vasopressin/cAMP/PKA-Dependent Signaling in Kidney
Karim Salhadar, Allanah Matthews, Viswanathan Raghuram, Kavee Limbutara, Chin-Rang Yang, Arnab Datta, Chung-Lin Chou and Mark A. Knepper

Molecular Pharmacology April 3, 2020, mol.120.119602; DOI: https://doi.org/10.1124/mol.120.119602
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A concise review of concepts in opioid pharmacology up to the discovery of endogenous opioids
Brian M. Cox

Molecular Pharmacology March 31, 2020, mol.120.119420; DOI: https://doi.org/10.1124/mol.120.119420
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Bidirectional relationship between opioids and disrupted sleep: putative mechanisms
D. Eacret, S. C. Veasey and J. A. Blendy

Molecular Pharmacology March 20, 2020, mol.119.119107; DOI: https://doi.org/10.1124/mol.119.119107
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Recent progress in opioid research from an electrophysiological perspective
William T Birdsong and John T. Williams

Molecular Pharmacology March 20, 2020, mol.119.119040; DOI: https://doi.org/10.1124/mol.119.119040
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Defining a cellular map of cAMP nanodomains
Katharina Schleicher and Manuela Zaccolo

Molecular Pharmacology February 28, 2020, mol.119.118869; DOI: https://doi.org/10.1124/mol.119.118869
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RGS proteins as critical regulators of motor function and their implications in Parkinson's disease
Katelin E Ahlers-Dannen, Mackenzie M. Spicer and Rory A. Fisher

Molecular Pharmacology February 3, 2020, mol.119.118836; DOI: https://doi.org/10.1124/mol.119.118836

Perspectives

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Opioid Research: Past and Future
Rita J Valentino and Nora D Volkow

Molecular Pharmacology July 13, 2020, MOLPHARM-PER-2020-000093; DOI: https://doi.org/10.1124/molpharm.120.000093

Response letter

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Response to Comments on "Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk"
Nadine Kabbani and James L Olds

Molecular Pharmacology August 6, 2020, MOLPHARM-RSP-2020-000120; DOI: https://doi.org/10.1124/molpharm.120.000120

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