Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

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The actions of drug combinations on the GABAA receptor manifest as curvilinear isoboles of additivity
Daniel J Shin, Allison L Germann, Joseph H. Steinbach and Gustav Akk

Molecular Pharmacology August 8, 2017, mol.117.109595; DOI: https://doi.org/10.1124/mol.117.109595

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Selective HIF-1 Regulation under Nonhypoxic Conditions by the p42/p44 MAP Kinase Inhibitor, PD184161
Maroua Jalouli, Sophie Mokas, Catherine A Turgeon, Laurent Lamalice and Darren E Richard

Molecular Pharmacology August 16, 2017, mol.117.108654; DOI: https://doi.org/10.1124/mol.117.108654
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Splice variants of pH-sensitive chloride channel identify a key determinant of ivermectin sensitivity in the larvae of the silkworm Bombyx mori
Daiki Okuhara, Shogo Furutani, Katsuhiko Ito, Makoto Ihara and Kazuhiko Matsuda

Molecular Pharmacology August 14, 2017, mol.117.109199; DOI: https://doi.org/10.1124/mol.117.109199
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Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3).
Anastasios Chanalaris, Christine Doherty, Brian D Marsden, Gabriel Bambridge, Stephen P Wren, Hideaki Nagase and Linda Troeberg

Molecular Pharmacology August 10, 2017, mol.117.109397; DOI: https://doi.org/10.1124/mol.117.109397
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Molecular mechanism of taurocholate transport by the bile salt export pump, an ABC-transporter associated with intrahepatic cholestasis
Muhammad Imran Sohail, Diethart Schmid, Katrin Wlcek, Matthias Spork, Gergely Szakacs, Michael Trauner, Thomas Stockner and Peter Chiba

Molecular Pharmacology August 7, 2017, mol.117.108688; DOI: https://doi.org/10.1124/mol.117.108688
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Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms
Hoa TN Phan, Benita Sjogren and Richard R Neubig

Molecular Pharmacology August 7, 2017, mol.117.109215; DOI: https://doi.org/10.1124/mol.117.109215
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Nitro-oleic acid regulates endothelin signaling in human endothelial cells
Emilia Kansanen, Suvi M Kuosmanen, Anna-Kaisa Ruotsalainen, Heidi Hynynen and Anna-Liisa Levonen

Molecular Pharmacology August 4, 2017, mol.117.109751; DOI: https://doi.org/10.1124/mol.117.109751
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Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121)
Brandon M. Brown, Heesung Shim, Miao Zhang, Vladimir Yarov-Yarovoy and Heike Wulff

Molecular Pharmacology July 31, 2017, mol.117.109421; DOI: https://doi.org/10.1124/mol.117.109421
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A novel selective inverse agonist of the CB2 receptor as a radiolabeled tool compound for kinetic binding studies
Andrea Martella, Huub Sijben, Arne Rufer, Juergen Fingerle, Uwe Grether, Christoph Ullmer, Thomas Hartung, Ad IJzerman, Mario van der Stelt and Laura Heitman

Molecular Pharmacology July 26, 2017, mol.117.108605; DOI: https://doi.org/10.1124/mol.117.108605
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Altenusin, a non-steroidal microbial metabolite, attenuates non-alcoholic fatty liver disease by activating the farnesoid X receptor
Zhihui Zheng, Zanmei Zhao, Shuqiang Li, Xinhua Lu, Mengxi Jiang, Jie Lin, Yunqi An, Yang Xie, Meishu Xu, Wenbin Shen, Grace Guo, YIxian Huang, Song Li, Xuexia Zhang and Wen Xie

Molecular Pharmacology July 24, 2017, mol.117.108829; DOI: https://doi.org/10.1124/mol.117.108829
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Molecular basis of altered hERG1 channel gating induced by ginsenoside Rg3
Alison Gardner, Wei Wu, Steven Thomson, Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger and Michael Sanguinetti

Molecular Pharmacology July 13, 2017, mol.117.108886; DOI: https://doi.org/10.1124/mol.117.108886

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A System-independent Scale (ΔLog(max/EC₅₀)) of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias and Receptor Mutation
Terry P Kenakin

Molecular Pharmacology July 5, 2017, mol.117.108787; DOI: https://doi.org/10.1124/mol.117.108787

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