Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

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The actions of drug combinations on the GABAA receptor manifest as curvilinear isoboles of additivity
Daniel J Shin, Allison L Germann, Joseph H. Steinbach and Gustav Akk

Molecular Pharmacology August 8, 2017, mol.117.109595; DOI: https://doi.org/10.1124/mol.117.109595

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The anthracycline metabolite doxorubicinol abolishes RyR2 sensitivity to physiological changes in luminal Ca²⁺ through an interaction with calsequestrin
Amy Hanna, Alexander Lam, Chris Thekkedam, Hermia Willemse, Angela Fay Dulhunty and Nicole Beard

Molecular Pharmacology September 15, 2017, mol.117.108183; DOI: https://doi.org/10.1124/mol.117.108183
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Agonist-dependent and -independent kappa opioid receptor phosphorylation showed distinct phosphorylation patterns and resulted in different cellular outcomes
Yi-Ting Chiu, Chongguang Chen, Daohai Yu, Stefan Schulz and Lee-Yuan Liu-Chen

Molecular Pharmacology September 11, 2017, mol.117.108555; DOI: https://doi.org/10.1124/mol.117.108555
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Teaching an old drug new tricks: agonism, antagonism and biased signaling of pilocarpine through M3 muscarinic acetylcholine receptor
Alexey Pronin, Qiang Wang and Vladlen Z Slepak

Molecular Pharmacology September 11, 2017, mol.117.109678; DOI: https://doi.org/10.1124/mol.117.109678
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A Single Amino Acid Substitution in the Third Transmembrane Region Has Opposite Impacts on the Selectivity of the Parasiticides Fluralaner and Ivermectin for Ligand-Gated Chloride Channels
Yunosuke Nakata, Toshinori Fuse, Kohei Yamato, Miho Asahi, Kunimitsu Nakahira, Fumiyo Ozoe and Yoshihisa Ozoe

Molecular Pharmacology September 8, 2017, mol.117.109413; DOI: https://doi.org/10.1124/mol.117.109413
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Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signalling Junctions and Protein Kinase A
Emily J.A. Taylor, Evangelia Pantazaka, Kathryn L. Shelley and Colin W. Taylor

Molecular Pharmacology September 6, 2017, mol.117.109249; DOI: https://doi.org/10.1124/mol.117.109249
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Distinct Signaling Patterns of Allosteric Antagonism at the P2Y₁ Receptor
Zhan-Guo Gao and Kenneth A. Jacobson

Molecular Pharmacology September 1, 2017, mol.117.109660; DOI: https://doi.org/10.1124/mol.117.109660
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TGF-β1/ALK5-mediated cell migration is dependent on the protein PAR2 but not on PAR2-stimulated Gq-calcium signaling
Hendrik Ungefroren, David Witte, Koichiro Mihara, Bernhard H Rauch, Petra Henklein, Olaf Johren, Shirin Bonni, Utz Settmacher, Hendrik Lehnert, Morley D Hollenberg, Roland Kaufmann and Frank Gieseler

Molecular Pharmacology August 25, 2017, mol.117.109017; DOI: https://doi.org/10.1124/mol.117.109017
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E6130, a novel CX3CR1 modulator, attenuates mucosal inflammation and reduces CX3CR1+ leukocyte trafficking in two murine colitis models
Hisashi Wakita, Tatsuya Yanagawa, Yoshikazu Kuboi and Toshio Imai

Molecular Pharmacology August 25, 2017, mol.117.108381; DOI: https://doi.org/10.1124/mol.117.108381
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N-acetyl-L-cysteine protects astrocytes against proteotoxicity without recourse to glutathione
Amanda M Gleixner, Daniel F Hutchison, Sara Sannino, Tarun N Bhatia, Lillian C Leak, Patrick T Flaherty, Peter Wipf, Jeffrey L Brodsky and Rehana K Leak

Molecular Pharmacology August 22, 2017, mol.117.109926; DOI: https://doi.org/10.1124/mol.117.109926
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Selective HIF-1 Regulation under Nonhypoxic Conditions by the p42/p44 MAP Kinase Inhibitor, PD184161
Maroua Jalouli, Sophie Mokas, Catherine A Turgeon, Laurent Lamalice and Darren E Richard

Molecular Pharmacology August 16, 2017, mol.117.108654; DOI: https://doi.org/10.1124/mol.117.108654

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