Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Lipophilicity of the Cystic Fibrosis drug, Ivacaftor, and its destabilizing effect on the major CF-causing mutation: F508del.
Stephanie Chin, Maurita Hung, Amy Won, Yu-Sheng Wu, Saumel Ahmadi, Donghe Yang, Salma Elmallah, Krimo Toutah, C. Michael Hamilton, Robert N. Young, Russell D. Viirre, Christopher M. Yip and Christine E. Bear

Molecular Pharmacology June 14, 2018, mol.118.112177; DOI: https://doi.org/10.1124/mol.118.112177
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Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992
Sujay V. Kharade, Haruto Kurata, Aaron Bender, Anna L. Blobaum, Eric E. Figueroa, Amanda M. Duran, Meghan Kramer, Emily Days, Paige Vinson, Daniel Flores, Lisa M. Satlin, Jens Meiler, C. David Weaver, Craig W. Lindsley, Corey R. Hopkins and Jerod S. Denton

Molecular Pharmacology June 13, 2018, mol.118.112359; DOI: https://doi.org/10.1124/mol.118.112359
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Application of Mixture Design Response Surface Methodology for Combination Chemotherapy in PC-3 Human Prostate Cancer Cells
Richard V Oblad, Hayden Doughty, John Lawson, Merrill Christensen and Jason Kenealey

Molecular Pharmacology June 8, 2018, mol.117.111450; DOI: https://doi.org/10.1124/mol.117.111450
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Assessment of Substrate Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates
Philip J Sandoval, Kimberely M Zorn, Alex M Clark, Sean Ekins and Stephen H Wright

Molecular Pharmacology June 8, 2018, mol.117.111443; DOI: https://doi.org/10.1124/mol.117.111443
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Identification of WB4101, an alpha1-adrenoceptor antagonist, as a sodium channel blocker
Min Li, Ying Wu, Beiyan Zou, Xiaoliang Wang, Min Li and Haibo Yu

Molecular Pharmacology June 8, 2018, mol.117.111252; DOI: https://doi.org/10.1124/mol.117.111252
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Inhibition of class I histone deacetylases abrogates TGFβ expression and development of fibrosis during chronic pancreatitis
Marta Bombardo, Rong Chen, Ermanno Malagola, Enrica Saponara, Andrew P Hills, Rolf Graf and Sabrina Sonda

Molecular Pharmacology June 7, 2018, mol.117.110924; DOI: https://doi.org/10.1124/mol.117.110924
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Transmembrane domain 1 of human organic anion transporting polypeptide 2B1 is essential for transporter function and stability
Zihui Fang, Jiujiu Huang, Jie Chen, Shaopeng Xu, Zhaojian Xiang and Mei Hong

Molecular Pharmacology June 5, 2018, mol.118.111914; DOI: https://doi.org/10.1124/mol.118.111914
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Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition
Cheng Chang, Kari R Fonseca, Cheryl Li, Weldon Horner, Laura Zawadzke, Michelle A Salafia, Kathryn A Welch, Christine Strick, Brian Campbell, Steven Gernhardt, Haojing Rong, Aarti Sawant-Basak, Jenney Liras, Amy Dounay, Jamison B Tuttle, Patrick R Verhoest and Tristan S Maurer

Molecular Pharmacology May 31, 2018, mol.118.111625; DOI: https://doi.org/10.1124/mol.118.111625
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Novel paradigms governing β1-adrenergic receptor trafficking in primary adult rat cardiac myocytes
Mohammed M Nooh, Salvatore Mancarella and Suleiman W Bahouth

Molecular Pharmacology May 30, 2018, mol.118.112045; DOI: https://doi.org/10.1124/mol.118.112045
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Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury
Todd R Harris, Sean Kodani, Amy A Rand, Jun Yang, Denise M Imai, Sung Hee Hwang and Bruce D. Hammock

Molecular Pharmacology May 29, 2018, mol.118.111831; DOI: https://doi.org/10.1124/mol.118.111831
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Small Molecule Positive Allosteric Modulators of the β₂-Adrenoceptor Isolated from DNA Encoded Libraries
Seungkirl Ahn, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, Mikkel Vestrgaard, Lei Jin, Shuai Zhao, Laura M. Wingler, Paula K. Rambarat, Rishabh K. Simhal, Thomas T. Xu, Lillian D. Sun, Paul J. Shim, Dean P. Staus, Li-Yin Huang, Thomas Franch, Xin Chen and Robert J. Lefkowitz

Molecular Pharmacology May 16, 2018, mol.118.111948; DOI: https://doi.org/10.1124/mol.118.111948
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Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction
Rance Nault, Claire M Doskey, Kelly A Fader, Cheryl E Rockwell and Timothy R Zacharewski

Molecular Pharmacology May 11, 2018, mol.118.112144; DOI: https://doi.org/10.1124/mol.118.112144
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Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
Philipp Y. Maximov, Balkees Abderrahman, Sean W. Fanning, Surojeet Sengupta, Ping Fan, Ramona F. Curpan, Daniela Maria Quintana Rincon, Jeffery A. Greenland, Shyamala S. Rajan, Geoffrey L. Greene and V. Craig Jordan

Molecular Pharmacology May 9, 2018, mol.117.111385; DOI: https://doi.org/10.1124/mol.117.111385
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The effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling and hepatic inflammation
Zhibo Gai, Michele Visentin, Ting Gui, Lin Zhao, Wolfgang E Thasler, Stephanie Hausler, Ivan Hartling, Alessio Cremonesi, Christian Hiller and Gerd A Kullak-Ublick

Molecular Pharmacology May 9, 2018, mol.117.111047; DOI: https://doi.org/10.1124/mol.117.111047

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Small molecular inhibitors targeting protein SUMOylation as novel anticancer compounds
Yanfang Yang, Zijing Xia, Xixi Wang, Xinyu Zhao, Zenghua Sheng, Yang Ye, Gu He, Liangxue Zhou, Hongxia Zhu, Ningzhi Xu and Shufang Liang

Molecular Pharmacology May 21, 2018, mol.118.112300; DOI: https://doi.org/10.1124/mol.118.112300

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