Online Ahead of Print

Last updated November 5, 2009

Papers published online before print


About Molecular Pharmacology Fast Forward:

November 5, 2009

    Article:
    • Geza Berecki,
    • Leonid Motin,
    • Alison Haythornthwaite,
    • Simone Vink,
    • Paramjit Bansal,
    • Roger Drinkwater,
    • Ching I Wang,
    • Melissa Moretta,
    • Richard J Lewis,
    • Paul F Alewood,
    • MacDonald J Christie,
    • and David J Adams
    ANALGESIC ω-CONOTOXINS CVIE AND CVIF SELECTIVELY AND VOLTAGE DEPENDENTLY BLOCK RECOMBINANT AND NATIVE N-TYPE CALCIUM CHANNELS Mol Pharmacol mol.109.058834; published ahead of print November 5, 2009, doi:10.1124/mol.109.058834

November 4, 2009

    Article:
    • Yuanyuan Zhang,
    • Tianyong Zhao,
    • Wei Li,
    • and Mary Vore
    The 5'-untranslated region of multidrug resistance associated protein 2 (MRP2; ABCC2) regulates downstream open reading frame expression through translational regulation Mol Pharmacol mol.109.058982; published ahead of print November 4, 2009, doi:10.1124/mol.109.058982

October 28, 2009

    Article:
    • Haitao You,
    • Christophe Altier,
    • and Gerald W Zamponi
    CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels Mol Pharmacol mol.109.059022; published ahead of print October 28, 2009, doi:10.1124/mol.109.059022

October 26, 2009

    Minireview:
    • Yutaro Obara and
    • Norimichi Nakahata
    The signaling pathway leading to ERK5 activation via G-proteins and ERK5-dependent neurotrophic effects Mol Pharmacol mol.109.060236; published ahead of print October 26, 2009, doi:10.1124/mol.109.060236

October 23, 2009

    Article:
    • Hui Zheng,
    • Yan Zeng,
    • Xiaoxiao Zhang,
    • Ji Chu,
    • Horace H. Loh,
    • and Ping-Yee Law
    μ-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD Mol Pharmacol mol.109.060848; published ahead of print October 23, 2009, doi:10.1124/mol.109.060848
    Article:
    • Alan Chu,
    • Jeremy S Caldwell,
    • and Yu Alice Chen
    Identification and Characterization of a Small Molecule Antagonist of Human VPAC2 Receptor Mol Pharmacol mol.109.060137; published ahead of print October 23, 2009, doi:10.1124/mol.109.060137

October 21, 2009

    Article:
    • Marcel P. Goldschen-Ohm,
    • David A. Wagner,
    • Steven Petrou,
    • and Mathew V. Jones
    An epilepsy-related region in the GABAA receptor mediates long-distance effects on GABA and benzodiazepine binding sites. Mol Pharmacol mol.109.058289; published ahead of print October 21, 2009, doi:10.1124/mol.109.058289
    Article:
    • Pavle M Joksovic,
    • WonJoo Choe,
    • Michael T Nelson,
    • Peihan Orestes,
    • Barbara C Brimelow,
    • and Slobodan M Todorovic
    Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway Mol Pharmacol mol.109.059931; published ahead of print October 21, 2009, doi:10.1124/mol.109.059931

October 20, 2009

    Article:
    • Pia Kotokorpi,
    • Nicolas Venteclef,
    • Ewa Ellis,
    • Jan-Ake Gustafsson,
    • and Agneta Mode
    The human ADFP gene is a direct LXR target gene and differentially regulated by synthetic LXR ligands. Mol Pharmacol mol.109.059063; published ahead of print October 20, 2009, doi:10.1124/mol.109.059063
    Article:
    • Sreevidya Aluvila,
    • Jiakang Sun,
    • David H.T. Harrison,
    • D. Eric Walters,
    • and Ronald S Kaplan
    Inhibitors of the Mitochondrial Citrate Transport Protein: Validation of the Role of Substrate Binding Residues and Discovery of the First Purely Competitive Inhibitor Mol Pharmacol mol.109.058750; published ahead of print October 20, 2009, doi:10.1124/mol.109.058750

October 16, 2009

    Article:
    • Shaun P. Brothers,
    • S. Adrian Saldanha,
    • Timothy P. Spicer,
    • Michael Cameron,
    • Becky A. Mercer,
    • Peter Chase,
    • Patricia McDonald,
    • Claes Wahlestedt,
    • and Peter S. Hodder
    Selective and Brain Penetrant Neuropeptide Y Y2 Receptor Antagonists Discovered by Whole-Cell High Throughput Screening Mol Pharmacol mol.109.058677; published ahead of print October 16, 2009, doi:10.1124/mol.109.058677
    Minireview:
    • Brian D Hudson,
    • Terence E Hebert,
    • and Melanie EM Kelly
    Ligand and Heterodimer Directed Signaling of the CB1 Cannabinoid Receptor Mol Pharmacol mol.109.060251; published ahead of print October 16, 2009, doi:10.1124/mol.109.060251

October 14, 2009

    Article:
    • Jong-Ho Lee,
    • Hexiu Jin,
    • Hye-Eun Shim,
    • Ha-Neui Kim,
    • Hyunil Ha,
    • and Zang Hee Lee
    Epigallocatechin-3-gallate inhibits osteoclastogenesis by down-regulating c-Fos expression and suppressing the NF-κB signal Mol Pharmacol mol.109.057877; published ahead of print October 14, 2009, doi:10.1124/mol.109.057877

September 15, 2009

    Article:
    • Ju-Chi Liu,
    • Cheng-Hsien Chen,
    • Jin-Jer Chen,
    • and Tzu-Hurng Cheng
    Urotensin II induces rat cardiomyocyte hypertrophy via the transient oxidization of Src homology 2-containing tyrosine phosphatase and transactivation of epidermal growth factor receptor Mol Pharmacol ; published ahead of print September 15, 2009, doi:10.1124/mol.109.058297
    Article:
    • Laura Milan-Lobo,
    • Ingrid Gsandtner,
    • Erwin Gaubitzer,
    • Dominik Runzler,
    • Florian Buchmayer,
    • Gottfried Kohler,
    • Antonello Bonci,
    • Michael Freissmuth,
    • and Harald Sitte
    Subtype-specific Differences in CRF Receptor Complexes Detected by Fluorescence Spectroscopy Mol Pharmacol ; published ahead of print September 15, 2009, doi:10.1124/mol.109.059139

September 14, 2009

    Article:
    • Sabine Depauw,
    • Thomas Gaslonde,
    • Stephane Leonce,
    • Laurence Kraus-Berthier,
    • William Laine,
    • Gaelle Lenglet,
    • Angele Chiaroni,
    • Bruno Pfeiffer,
    • Christian Bailly,
    • Sylvie Michel,
    • Francois Tillequin,
    • Alain Pierre,
    • and Marie-Helene David-Cordonnier
    Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix opening, cytotoxic and anti-tumor activities Mol Pharmacol ; published ahead of print September 14, 2009, doi:10.1124/mol.109.057554
    Article:
    • Tengis S Pavlov,
    • Vladislav Levchenko,
    • Alexey V Karpushev,
    • Alain Vandewalle,
    • and Alexander Staruschenko
    PPARγ antagonists decrease Na+ transport via the epithelial Na+ channel (ENaC) Mol Pharmacol ; published ahead of print September 14, 2009, doi:10.1124/mol.109.056911

September 11, 2009

    Article:
    • Serife Cankurtaran-Sayar,
    • Kemal Sayar,
    • and Mehmet Ugur
    P2X7 RECEPTOR ACTIVATES MULTIPLE SELECTIVE DYE PERMEATION PATHWAYS IN RAW 264.7 AND HEK-293 CELLS Mol Pharmacol ; published ahead of print September 11, 2009, doi:10.1124/mol.109.059923

September 9, 2009

    Article:
    • Susanne Reiner,
    • Nicole Ziegler,
    • Cathrine Leon,
    • Kristina Lorenz,
    • Kathrin von Hayn,
    • Christian Gachet,
    • Martin J Lohse,
    • and Carsten Hoffmann
    β-ARRESTIN-2 INTERACTION AND INTERNALIZATION OF THE HUMAN P2Y1-RECEPTOR ARE DEPENDENT ON C-TERMINAL PHOSPHORLAYTION SITES Mol Pharmacol ; published ahead of print September 9, 2009, doi:10.1124/mol.109.060467
    Article:
    • Shary N Shelton,
    • Mary E Shawgo,
    • Shawna B Comer,
    • Yuanming Lu,
    • Alison C Donnelly,
    • Kristen Szabla,
    • Mehmet Tanol,
    • George A Vielhauer,
    • Roger A Rajewski,
    • Robert L Matts,
    • Brian S J Blagg,
    • and John D Robertson
    KU135, a Novel Novobiocin-derived C-terminal Inhibitor of Hsp90, Exerts Potent Antiproliferative Effects in Human Leukemic Cells Mol Pharmacol ; published ahead of print September 9, 2009, doi:10.1124/mol.109.058545
    Article:
    • Ligong Chen,
    • Gregory D Salinas,
    • and Xiaohua Li
    Regulation of Serotonin 1B Receptor by Glycogen Synthase Kinase-3 Mol Pharmacol ; published ahead of print September 9, 2009, doi:10.1124/mol.109.056994

September 8, 2009

    Article:
    • Sophie J Bradley,
    • Jeannette M. Watson,
    • and R.A. John Challiss
    Effects of Positive Allosteric Modulators on Single Cell Oscillatory Ca2+ Signaling Initiated by the Type 5 Metabotropic Glutamate (mGlu5) Receptor Mol Pharmacol ; published ahead of print September 8, 2009, doi:10.1124/mol.109.059170

September 4, 2009

    Article:
    • Haiyan Liu,
    • Judith A. Enyeart,
    • and John J. Enyeart
    N6-substituted cAMP Analogs Inhibit bTREK-1 K+ Channels and Stimulate Cortisol Secretion by a PKA-Independent Mechanism Mol Pharmacol ; published ahead of print September 4, 2009, doi:10.1124/mol.109.057075

September 2, 2009

    Article:
    • Susan Oldfield,
    • Jane M Hancock,
    • Angharad Mason,
    • Sally A Hobson,
    • David Wynick,
    • Eamonn Kelly,
    • Andrew D Randall,
    • and Neil V Marrion
    Receptor-mediated suppression of potassium currents requires co-localization within lipid rafts. Mol Pharmacol ; published ahead of print September 2, 2009, doi:10.1124/mol.109.058008

November 16, 2007

    Article:
    • Keith R Stayrook,
    • Pamela M Rogers,
    • Rajesh S Savkur,
    • Yongjun Wang,
    • Chen Su,
    • Gabor Varga,
    • Xin Bu,
    • Tao Wei,
    • Sunil Nagpal,
    • Xiaole Shirley Liu,
    • and Thomas P Burris
    REGULATION OF HUMAN 3α-HYDROXYSTEROID DEHYDROGENASE (AKR1C4) EXPRESSION BY THE LIVER X RECEPTOR α Mol Pharmacol ; published ahead of print November 16, 2007, doi:10.1124/mol.107.039099
    Article:
    • Jessica Radzio and
    • Nicolas Sluis-Cremer
    Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage Leading to Diminished Zidovudine Excision Mol Pharmacol ; published ahead of print November 16, 2007, doi:10.1124/mol.107.038596

November 15, 2007

    Article:
    • David M Lehmann,
    • Pramodh Seneviratne,
    • and Alan V Smrcka
    Small Molecule Disruption of G Protein βγ Subunit Signaling Inhibits Neutrophil Chemotaxis and Inflammation Mol Pharmacol ; published ahead of print November 15, 2007, doi:10.1124/mol.107.041780
    Article:
    • Yumei Fu,
    • Shizhong Zheng,
    • Jianguo Lin,
    • Jan Ryerse,
    • and Anping Chen
    Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation Mol Pharmacol ; published ahead of print November 15, 2007, doi:10.1124/mol.107.039818
    Article:
    • Chenqi Zhao,
    • Maria Fernandes,
    • Glenn Prestwich,
    • Melanie Turgeon,
    • John Di Battista,
    • Timothy Clair,
    • Patrice Poubelle,
    • and Sylvain Bourgoin
    Regulation of Lysophosphatidic Acid Receptor Expression and Function in Human Synoviocytes: Implications for Rheumatoid Arthritis? Mol Pharmacol ; published ahead of print November 15, 2007, doi:10.1124/mol.107.038216

November 14, 2007

    Article:
    • Elin Swedenborg,
    • Joelle Ruegg,
    • Anne Hillenweck,
    • Stefan Rehnmark,
    • Malin Hedengran Faulds,
    • Daniel Zalko,
    • Ingemar Pongratz,
    • and Katarina Pettersson
    3-methyl cholanthrene displays dual effects on ERα and ERβ signaling in a cell-type specific fashion Mol Pharmacol ; published ahead of print November 14, 2007, doi:10.1124/mol.107.036384

November 13, 2007

    Accelerated Communication:
    • Thomas E Taylor-Clark,
    • Bradley J. Undem,
    • Donald W MacGlashan, Jr.,
    • Srinivas Ghatta,
    • Michael J Carr,
    • and M. Allen McAlexander
    Prostaglandin-induced activation of nociceptive neurons via direct interaction with TRPA1 Mol Pharmacol ; published ahead of print November 13, 2007, doi:10.1124/mol.107.040832
    Article:
    • Brad R Evans,
    • Sibel I Karchner,
    • Lenka L Allan,
    • Richard S Pollenz,
    • Robert L Tanguay,
    • Matthew J Jenny,
    • David H. Sherr,
    • and Mark E Hahn
    Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor (AHRR): Role of DNA binding and competition for ARNT Mol Pharmacol ; published ahead of print November 13, 2007, doi:10.1124/mol.107.040204
    Article:
    • Laura Heitman,
    • Julia Oosterom,
    • Kimberly Bonger,
    • Cornelis Timmers,
    • Peter Wiegerinck,
    • and Ad P. IJzerman
    [3H]Org 43553, the First Low Molecular Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor Mol Pharmacol ; published ahead of print November 7, 2007, doi:10.1124/mol.107.039875

November 9, 2007

    Article:
    • Wei Xiong,
    • Masako Hosoi,
    • BonNyeo Koo,
    • and Li Zhang
    Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization Mol Pharmacol ; published ahead of print November 9, 2007, doi:10.1124/mol.107.039149
    Article:
    • Ekaitz Errasti-Murugarren,
    • Pedro Cano-Soldado,
    • Marcal Pastor-Anglada,
    • and Francisco Javier Casado
    FUNCTIONAL CHARACTERIZATION OF A NUCLEOSIDE-DERIVED DRUG TRANSPORTER VARIANT (hCNT3C602R) SHOWING ALTERED SODIUM-BINDING CAPACITY Mol Pharmacol ; published ahead of print November 9, 2007, doi:10.1124/mol.107.041848
    Article:
    • Anna M Misior,
    • Huandong Yan,
    • Rodolfo M Pascual,
    • Deepak A Deshpande,
    • Reynold A Panettieri, Jr.,
    • and Raymond B Penn
    Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors Mol Pharmacol ; published ahead of print November 9, 2007, doi:10.1124/mol.107.040519

November 8, 2007

    Article:
    • Lisa M Greene,
    • Giuseppe Campiani,
    • Mark Lawler,
    • David Clive Williams,
    • and Daniela M Zisterer
    BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin targeting pyrrolo-1,5-benzoxazepines Mol Pharmacol ; published ahead of print November 8, 2007, doi:10.1124/mol.107.039024

November 7, 2007

    Article:
    • Paul D Upton,
    • Lu Long,
    • Richard C Trembath,
    • and Nicholas W Morrell
    Functional Characterization of BMP Binding Sites and Smad1/5 Activation in Human Vascular Cells Mol Pharmacol ; published ahead of print November 7, 2007, doi:10.1124/mol.107.041673
    Article:
    • Sabitha Papineni,
    • Sudhakar Chintharlapalli,
    • and Stephen Safe
    Methyl 2-Cyano-3,11-Dioxo-18β-Olean-1,12-Dien-30-Oate Is A Peroxisome Proliferator-Activated Receptor γ Agonist That Induces Receptor-Independent Apoptosis In LNCaP Prostate Cancer Cells Mol Pharmacol ; published ahead of print November 7, 2007, doi:10.1124/mol.107.041285
    Article:
    • Andrew Holt,
    • David J. Smith,
    • Laura Cendron,
    • Giuseppe Zanotti,
    • Adelio Rigo,
    • and Maria Luisa Di Paolo
    Multiple binding sites for substrates and modulators of semicarbazide-sensitive amine oxidases: kinetic consequences Mol Pharmacol ; published ahead of print November 7, 2007, doi:10.1124/mol.107.040964
    Article:
    • Shengwei Zou,
    • Smita Jha,
    • Eun Young Kim,
    • and Stuart E Dryer
    The β1 subunit of L-type voltage-gated Ca2+ channels independently binds to and inhibits the gating of large-conductance Ca2+-activated K+ channels Mol Pharmacol ; published ahead of print November 7, 2007, doi:10.1124/mol.107.040733
    Article:
    • Shengwei Zou,
    • Smita Jha,
    • Eun Young Kim,
    • and Stuart E Dryer
    A novel actin-binding domain on Slo1 calcium-activated potassium channels is necessary for their expression in the plasma membrane Mol Pharmacol ; published ahead of print November 7, 2007, doi:10.1124/mol.107.039743
    Article:
    • Laura Papucci,
    • Ewa Witort,
    • Annamaria Bevilacqua,
    • Martino Donnini,
    • Matteo Lulli,
    • Elisabetta Borchi,
    • Khalid S.A. Khabar,
    • Alessio Tempestini,
    • Andrea Lapucci,
    • Nicola Schiavone,
    • Angelo Nicolin,
    • and Sergio Capaccioli
    Impact of targeting the AU-rich element of bcl-2 mRNA with oligoribonucleotides on apoptosis, cell cycle and neuronal differentiation in SHSY-5Y cells Mol Pharmacol ; published ahead of print November 7, 2007, doi:10.1124/mol.107.038323

November 6, 2007

    Article:
    • Rasmus Jorgensen,
    • Nicholas D Holliday,
    • Jakob L Hansen,
    • Milka Vrecl,
    • Anders Heding,
    • Thue W Schwartz,
    • and Christian E Elling
    Characterization of G-Protein Coupled Receptor Kinase Interaction with the NK-1 Receptor Using BRET Mol Pharmacol ; published ahead of print November 6, 2007, doi:10.1124/mol.107.038877

November 5, 2007

    Article:
    • Salvatore Cuzzocrea,
    • Stefano Bruscoli,
    • Emanuela Mazzon,
    • Concetta Crisafulli,
    • Valerio Donato,
    • Rosanna Di Paola,
    • Enrico Velardi,
    • Emanuela Esposito,
    • Giuseppe Nocentini,
    • and Carlo riccardi
    PPAR-α contributes to the anti-inflammatory activity of glucocorticoids Mol Pharmacol ; published ahead of print November 5, 2007, doi:10.1124/mol.107.041475
    Article:
    • Zhiyong Liao,
    • Robert W. Robey,
    • Josee Guirouilh-Barbat,
    • Kenneth K. W. To,
    • Orsolya Polgar,
    • Susan E. Bates,
    • and Yves Pommier
    Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan Mol Pharmacol ; published ahead of print November 5, 2007, doi:10.1124/mol.107.041178

November 2, 2007

    Perspective:
    • Joseph N. Contessa and
    • Daniel A. Hamstra
    Revoking the Privilege: Targeting HER2 in the CNS (Relates to article by Emanuel, et al., Fast Forward 1 Nov 07) Mol Pharmacol ; published ahead of print November 2, 2007, doi:10.1124/mol.107.042986
    Article:
    • Qisheng Liu,
    • Dian A. Dewi,
    • Weiley S. Liu,
    • Mark S. Bee,
    • and Agnes Schonbrunn
    Distinct phosphorylation sites in the sst2 somatostatin receptor control internalization, desensitization, and arrestin binding Mol Pharmacol ; published ahead of print November 2, 2007, doi:10.1124/mol.107.038570

November 1, 2007

    Article:
    • Stuart L Emanuel,
    • Terry V Hughes,
    • Mary Adams,
    • Catherine A Rugg,
    • Angel Fuentes-Pesquera,
    • Peter J Connolly,
    • Niranjan Pandey,
    • Sandra Moreno-Mazza,
    • Jeannene Butler,
    • Virna Borowski,
    • Steven A Middleton,
    • Robert H Gruninger,
    • Jennifer R Story,
    • Cheryl Napier,
    • Beth Hollister,
    • and Lee M Greenberger
    Cellular and in vivo activity of JNJ-28871063: a non-quinazoline pan-ErbB kinase inhibitor that crosses the blood brain barrier and displays efficacy against intracranial tumors Mol Pharmacol ; published ahead of print November 1, 2007, doi:10.1124/mol.107.041236
    Article:
    • Renaud Robert,
    • Graeme W Carlile,
    • Catalin Pavel,
    • Na Liu,
    • Suzana M Anjos,
    • Jie Liao,
    • Yishan Luo,
    • Donglei Zhang,
    • David Y Thomas,
    • and John W Hanrahan
    Structural analogue of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect Mol Pharmacol ; published ahead of print November 1, 2007, doi:10.1124/mol.107.040725
    Article:
    • Ivar von Kugelgen,
    • Anke C Schiedel,
    • Kristina Hoffmann,
    • Bernt BA Alsdorf,
    • Aliaa Abdelrahman,
    • and Christa E Muller
    Cloning and Functional Expression of a Novel Gi Protein-Coupled Receptor for Adenine from Mouse Brain Mol Pharmacol ; published ahead of print November 1, 2007, doi:10.1124/mol.107.037069

October 31, 2007

    Article:
    • Roohangiz Safaei,
    • Shinji Otani,
    • Barrett J Larson,
    • Michael L Rasmussen,
    • and Stephen B Howell
    Transport of cisplatin by the copper efflux transporter ATP7B Mol Pharmacol ; published ahead of print October 31, 2007, doi:10.1124/mol.107.040980
    Article:
    • Tania Onica,
    • Kathleen Nichols,
    • Meghan Larin,
    • Lorraine Ng,
    • Ann Maslen,
    • Zdenek Dvorak,
    • Jean-Marc Pascussi,
    • Marie-Josee Vilarem,
    • Patrick Maurel,
    • and Gordon Kirby
    Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of HNF4α to the proximal promoter Mol Pharmacol ; published ahead of print October 31, 2007, doi:10.1124/mol.107.039354

October 30, 2007

    Article:
    • Naissan Hussainzada,
    • Akash Khandelwal,
    • and Peter W. Swaan
    Conformational Flexibility of Helix VI is Essential for Substrate Permeation of the Human Apical Sodium-dependent Bile Acid Transporter (ASBT) Mol Pharmacol ; published ahead of print October 30, 2007, doi:10.1124/mol.107.041640
    Article:
    • Anja Zeller,
    • Florence Crestani,
    • Isabelle Camenisch,
    • Takuji Iwasato,
    • Shigeyoshi Itohara,
    • Jean-Marc Fritschy,
    • and Uwe Rudolph
    Cortical glutamatergic neurons mediate the motor sedative action of diazepam Mol Pharmacol ; published ahead of print October 26, 2007, doi:10.1124/mol.107.038828

October 26, 2007

    Article:
    • Douglas McHugh,
    • Carolyn Tanner,
    • Raphael Mechoulam,
    • Roger G Pertwee,
    • and Ruth A Ross
    INHIBITION OF HUMAN NEUTROPHIL CHEMOTAXIS BY ENDOGENOUS CANNABINOIDS AND PHYTOCANNABINODS: EVIDENCE FOR A SITE DISTINCT FROM CB1 AND CB2 Mol Pharmacol ; published ahead of print October 26, 2007, doi:10.1124/mol.107.041863
    Article:
    • Marie Parat,
    • Normand McNicoll,
    • Brian Wilkes,
    • Alain Fournier,
    • and Andre DE LEAN
    Role of Extracellular Domain Dimerization in Agonist-Induced Activation of Natriuretic Peptide Receptor-A Mol Pharmacol ; published ahead of print October 26, 2007, doi:10.1124/mol.107.039982

October 25, 2007

    Article:
    • Ralph Kratzner,
    • Florian Frohlich,
    • Katrin Lepler,
    • Michaela Schroder,
    • Katharina Roher,
    • Corinna Dickel,
    • Mladen V Tzvetkov,
    • Thomas Quentin,
    • Elke Oetjen,
    • and Willhart Knepel
    A Peroxisome Proliferator-activated Receptor γ - Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription* Mol Pharmacol ; published ahead of print October 25, 2007, doi:10.1124/mol.107.035568

April 8, 2005

    Article:
    • Michal Harel,
    • Janice L Hyatt,
    • Boris Brumshtein,
    • Christopher L Morton,
    • Kyoung Jin P Yoon,
    • Randy M Wadkins,
    • Israel Silman,
    • Joel L Sussman,
    • and Philip M Potter
    The crystal structure of the complex of the anticancer prodrug CPT-11 with Torpedo acetylcholinesterase provides a molecular explanation for its cholinergic action Mol Pharmacol ; published ahead of print March 16, 2005, doi:10.1124/mol.104.009944

March 28, 2005

    Article:
    • Somnath Mukhopadhyay and
    • Allyn C. Howlett
    Chemically Distinct Ligands Promote Differential CB1 Cannabinoid Receptor-Gi Protein Interactions Mol Pharmacol ; published ahead of print March 4, 2005, doi:10.1124/mol.104.003558

March 23, 2005

    Article:
    • Stefania Gessi,
    • Katia Varani,
    • Stefania Merighi,
    • Elena Cattabriga,
    • Cecilia Pancaldi,
    • Youri Szabadkai,
    • Rosario Rizzuto,
    • Karl-Norbert Klotz,
    • Edward Leung,
    • Steven Mac Lennan,
    • Pier Giovanni Baraldi,
    • and Pier Andrea Borea
    Expression, pharmacological profile and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells by using a novel selective antagonist radioligand, [3H]-MRE 2029F20 Mol Pharmacol ; published ahead of print March 23, 2005, doi:10.1124/mol.104.009225
    Article:
    • Richard D. Peavy,
    • Katherine B. Hubbard,
    • Anthony G. Lau,
    • R. Brett Fields,
    • Kaiming Xu,
    • C. Justin Lee,
    • Terri T. Lee,
    • Kim M. Gernert,
    • T. J. Murphy,
    • and John R. Hepler
    Differential effects of Gqα, G14α and G15α on vascular smooth muscle cells survival and gene expression profiles Mol Pharmacol ; published ahead of print March 23, 2005, doi:10.1124/mol.104.007799

March 22, 2005

    Perspective:
    • William P. Clarke
    What's for lunch at the conformational cafeteria? (Relates to Article by Mukhopadhyay, et al. FastForward 4 March 2005) Mol Pharmacol ; published ahead of print March 22, 2005, doi:10.1124/mol.105.013060
    Accelerated Communication:
    • olivier Boijoux,
    • Christelle Boutonnet,
    • Claire Giamarchi,
    • Gilles Favre,
    • stephan Vagner,
    • and jean-charles faye
    Chemical-based translational induction of luciferase expression: an efficient tool for the in vivo screening of protein farnesylation inhibitors Mol Pharmacol ; published ahead of print March 22, 2005, doi:10.1124/mol.105.011163
    Article:
    • Henrique Cheng,
    • Justin A Grodnitzky,
    • Sirintorn Yibchok-anun,
    • Jing Ding,
    • and Walter H Hsu
    Somatostatin increases phospholipase D activity and PIP2 synthesis in clonal β-cells HIT-T15 Mol Pharmacol ; published ahead of print March 22, 2005, doi:10.1124/mol.104.010470
    Article:
    • Sabine Traver,
    • Benedicte Salthun-Lassalle,
    • Marc Marien,
    • Etienne C Hirsch,
    • Francis Colpaert,
    • and Patrick P Michel
    The Neurotransmitter Noradrenaline Rescues Septal Cholinergic Neurons in Culture from Degeneration Caused by Low-Level Oxidative Stress Mol Pharmacol ; published ahead of print March 22, 2005, doi:10.1124/mol.104.007864

March 18, 2005

    Accelerated Communication:
    • Joanna Lawrence,
    • Stuart J Mundell,
    • Hongruo Yun,
    • Eamonn Kelly,
    • and Kanamarlapudi Venkateswarlu
    Centaurin-α1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits β2-Adrenoceptor Internalization Mol Pharmacol ; published ahead of print March 18, 2005, doi:10.1124/mol.105.011338
    Article:
    • Danxin Wang,
    • Xiaochun Sun,
    • Laura M Bohn,
    • and Wolfgang Sadee
    Opioid receptor homo- and hetero-dimerization in living cells by quantitative bioluminescence resonance energy transfer Mol Pharmacol ; published ahead of print March 18, 2005, doi:10.1124/mol.104.010272
    Article:
    • Marcel Fechir,
    • Katrin Linker,
    • Andrea Pautz,
    • Thomas Hubrich,
    • Ulrich Forstermann,
    • Fernando Rodriguez-Pascual,
    • and Hartmut Kleinert
    Tristetraprolin regulates the expression of the human inducible nitric oxide synthase gene Mol Pharmacol ; published ahead of print March 18, 2005, doi:10.1124/mol.104.008763
    Article:
    • Celia Pilar Martinez-Jimenez,
    • Maria Jose Gomez-Lechon,
    • Jose Vicente Castell,
    • and RAMIRO JOVER
    Transcriptional regulation of the human hepatic CYP3A4: Identification of a new distal enhancer region responsive to CCAAT/enhancer binding protein beta isoforms (LAP and LIP) Mol Pharmacol ; published ahead of print March 18, 2005, doi:10.1124/mol.104.008169

March 17, 2005

    Article:
    • Maoqing Dong,
    • Elizabeth M. Hadac,
    • Delia I. Pinon,
    • and Laurence J. Miller
    Differential spatial approximation between cholecystokinin residue 30 and receptor residues in active and inactive conformations Mol Pharmacol ; published ahead of print March 17, 2005, doi:10.1124/mol.105.012179
    Article:
    • Lankupalle D Jayanthi,
    • Devadoss J Samuvel,
    • Randy D. Blakely,
    • and Sammanda Ramamoorthy
    Evidence for Biphasic Effects of Protein Kinase C on Serotonin Transporter Function, Endocytosis, and Phosphorylation Mol Pharmacol ; published ahead of print March 17, 2005, doi:10.1124/mol.104.009555
    Article:
    • Sheela Rani,
    • Mei Qiang,
    • and Maharaj K Ticku
    Potential Role of CREB in Ethanol-induced NR2B Gene Transcription in Fetal Mouse Cortical Cells Mol Pharmacol ; published ahead of print March 17, 2005, doi:10.1124/mol.104.007872

March 16, 2005

    Article:
    • Rangnath Mishra,
    • Yuan Wang,
    • and Michael S. Simonson
    Cell Cycle Signaling by Endothelin-1 Requires Src Non-Receptor Protein Tyrosine Kinase Mol Pharmacol ; published ahead of print March 16, 2005, doi:10.1124/mol.104.010546
    Article:
    • Jingcai Chen,
    • Chester Kuei,
    • Steven Sutton,
    • Sandy Wilson,
    • Jingxue Yu,
    • Fredrik Kamme,
    • Curt Mazur,
    • Timothy W Lovenberg,
    • and Changlu Liu
    Identification and Pharmacological Characterization of Prokineticin 2β as a Selective Ligand for Prokineticin Receptor 1 Mol Pharmacol ; published ahead of print March 16, 2005, doi:10.1124/mol.105.011619
    Article:
    • Lei-Chin Chen,
    • Ben-Kuen Chen,
    • and Wen-Chang Chang
    AP1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun Mol Pharmacol ; published ahead of print March 16, 2005, doi:10.1124/mol.104.010900
    Article:
    • R. Benjamin Free,
    • Susan B. McKay,
    • Paul D. Gottlieb,
    • R. Thomas Boyd,
    • and Dennis B. McKay
    Expression of Native α3β4* Neuronal Nicotinic Receptors: Binding and Functional Studies Investigating Turnover of Surface and Intracellular Receptor Populations Mol Pharmacol ; published ahead of print March 16, 2005, doi:10.1124/mol.104.009282

March 15, 2005

    Article:
    • Guilin Wang,
    • Tiancheng Liu,
    • Li-Na Wei,
    • Ping-Yee Law,
    • and Horace H. Loh
    DNA METHYLATION-RELATED CHROMATIN MODIFICATION IN THE REGULATION OF MOUSE δ-OPIOID RECEPTOR GENE Mol Pharmacol ; published ahead of print March 15, 2005, doi:10.1124/mol.105.011056

March 10, 2005

    Article:
    • Roger L Papke,
    • Joshua D. Buhr,
    • Michael M. Francis,
    • Kyung Il Choi,
    • Jeffrey S Thinschmidt,
    • and Nicole A. Horenstein
    The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker TMPH Mol Pharmacol ; published ahead of print March 10, 2005, doi:10.1124/mol.105.011676
    Article:
    • Bernard Lagane,
    • Sebastien Ballet,
    • Thierry Planchenault,
    • Karl Balabanian,
    • Emmanuel Le Poul,
    • Cedric Blanpain,
    • Yann Percherancier,
    • Isabelle Staropoli,
    • Gilbert Vassart,
    • Martin Oppermann,
    • Marc Parmentier,
    • and Francoise Bachelerie
    Mutation of the DRY motif reveals different structural requirements for CCR5-mediated signaling and receptor endocytosis Mol Pharmacol ; published ahead of print March 10, 2005, doi:10.1124/mol.104.009779
    Article:
    • Oliver Burk,
    • Katja A Arnold,
    • Andreas K Nussler,
    • Elke Schaeffeler,
    • Ekaterina Efimova,
    • Bonnie A Avery,
    • Mitchell A Avery,
    • Martin F Fromm,
    • and Michel Eichelbaum
    Anti-malarial artemisinin drugs induce CYP and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor Mol Pharmacol ; published ahead of print March 10, 2005, doi:10.1124/mol.104.009019

March 9, 2005

    Article:
    • Tsuyoshi Okuda,
    • Xinjian Lin,
    • Julie Trang,
    • and Stephen B. Howell
    Suppression of hREV1 Expression Reduces the Rate at which Human Ovarian Carcinoma Cells Acquire Resistance to Cisplatin Mol Pharmacol ; published ahead of print March 9, 2005, doi:10.1124/mol.104.010579

March 8, 2005

    Article:
    • Juan Guo and
    • Stephen R Ikeda
    Coupling of metabotropic glutamate receptor 8 to N-type Ca2+ channels in rat sympathetic neurons Mol Pharmacol ; published ahead of print March 8, 2005, doi:10.1124/mol.105.010975
    Article:
    • Dezheng Zhao,
    • Yanai Zhan,
    • Huiyan Zeng,
    • Hon-Wai Koon,
    • Mary P Moyer,
    • and Charalabos Pothoulakis
    Neurotensin stimulates interleukin-8 expression through modulation of IκBα phosphorylation and p65 transcriptional activity: involvement of protein kinase C[alpha] Mol Pharmacol ; published ahead of print March 8, 2005, doi:10.1124/mol.104.010801
    Article:
    • Mei Qiang,
    • Sheela Rani Kadapakkam,
    • and Maharaj K. Ticku
    NRSF regulates the N-Methyl-D-aspartate receptor 2B subunit gene in basal and ethanol-induced gene expression in fetal cortical neurons Mol Pharmacol ; published ahead of print March 8, 2005, doi:10.1124/mol.104.010751
    Article:
    • Rex A Parker,
    • Oliver P Flint,
    • Ruth Mulvey,
    • Carolina Elosua,
    • Faye Wang,
    • William Fenderson,
    • Shulin Wang,
    • Wen-Pin Yang,
    • and Mustafa A Noor
    Endoplasmic Reticulum Stress Links Dyslipidemia to Inhibition of Proteasome Activity and Glucose Transport by HIV Protease Inhibitors Mol Pharmacol ; published ahead of print March 8, 2005, doi:10.1124/mol.104.010165
    Article:
    • Francois G Gervais,
    • Jean-Pierre Morello,
    • Christian Beaulieu,
    • Nicole Sawyer,
    • Danielle Denis,
    • Gillian Greig,
    • A. Daniel Malebranche,
    • and Gary P O'Neill
    Identification of a potent and selective synthetic agonist at the CRTH2 receptor Mol Pharmacol ; published ahead of print March 8, 2005, doi:10.1124/mol.104.009068
    Article:
    • LEA PAYEN,
    • MIAN GAO,
    • CHRISTOPHER WESTLAKE,
    • ASHLEY THEIS,
    • SUSAN P.C. COLE,
    • and ROGER G. DEELEY
    Functional Interactions Between Nucleotide Binding Domains and LTC4 Binding Sites of Multidrug Resistance Protein 1 (ABCC1) Mol Pharmacol ; published ahead of print March 8, 2005, doi:10.1124/mol.104.007708
    Article:
    • Qin M. Chen,
    • Donnia Alexander,
    • Haipeng Sun,
    • Lifang Xie,
    • Yan Lin,
    • Jerome Terrand,
    • Steve Morrissy,
    • and Sally Purdom
    Corticosteroids Inhibit Cell Death Induced by Doxorubicin in Cardiomyocytes: Induction of Anti-apoptosis, Antioxidant and Detoxification Genes Mol Pharmacol ; published ahead of print March 8, 2005, doi:10.1124/mol.104.003814

March 4, 2005

    Article:
    • Cecilia Gotti,
    • Milena Moretti,
    • Francesco Clementi1,
    • Loredana Riganti,
    • J. Michael McIntosh,
    • Allan C. Collins,
    • Michael J. Marks,
    • and Paul Whiteaker
    Expression of nigrostriatal α6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by β3 subunit gene deletion Mol Pharmacol ; published ahead of print March 4, 2005, doi:10.1124/mol.105.011940
    Article:
    • Nicoletta Pedemonte,
    • Nitin D Sonawane,
    • Alessandro Taddei,
    • Jie Hu,
    • Olga Zegarra-Moran,
    • Yat Fan Suen,
    • Lori I Robins,
    • Christopher W Dicus,
    • Dan Willenbring,
    • Michael H Nantz,
    • Mark J Kurth,
    • Luis JV Galietta,
    • and Alan S. Verkman
    PHENYLGLYCINE AND SULFONAMIDE CORRECTORS OF DEFECTIVE δF508- AND G551D-CFTR CHLORIDE CHANNEL GATING Mol Pharmacol ; published ahead of print February 18, 2005, doi:10.1124/mol.105.010959
    Article:
    • Aloys Sesink,
    • Ilja Arts,
    • Vincent de Boer,
    • Pauline Breedveld,
    • Jan Schellens,
    • Peter Hollman,
    • and Frans Russel
    Breast Cancer Resistance Protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides Mol Pharmacol ; published ahead of print March 4, 2005, doi:10.1124/mol.104.009753

March 1, 2005

    Article:
    • Attila Szanto and
    • Laszlo Nagy
    Retinoids potentiate PPARγ action in differentiation, gene expression and lipid metabolic processes in developing myeloid cells Mol Pharmacol ; published ahead of print March 1, 2005, doi:10.1124/mol.104.006445

February 28, 2005

    Article:
    • Derek Wallace,
    • LeeAnn Johnston,
    • Elaine Huston,
    • Douglas MacMaster,
    • Thomas M Houslay,
    • York-Fong Cheung,
    • Lachlan Campbell,
    • Jenni S Millen,
    • Robin A Smith,
    • Irene Gall,
    • Richard G Knowles,
    • Michael Sullivan,
    • and Miles D. Houslay
    Identification and characterisation of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cyclic AMP phosphodiesterase gene Mol Pharmacol ; published ahead of print February 28, 2005, doi:10.1124/mol.104.009423
    Article:
    • Maria Gomez-Benito,
    • Isabel Marzo,
    • Alberto Anel,
    • and Javier Naval
    Farnesyltransferase inhibitor BMS-214662 induces apoptosis in myeloma cells through PUMA upregulation, Bax and Bak activation and Mcl-1 elimination Mol Pharmacol ; published ahead of print February 28, 2005, doi:10.1124/mol.104.007021

February 25, 2005

    Perspective:
    • Gerhard Burckhardt
    Polyspecific organic cation transporters: insights into the substrate binding site (Relates to Articles by Popp, et al. & Gorboulev, et al. FastForward 20 January 2005) Mol Pharmacol ; published ahead of print February 25, 2005, doi:10.1124/mol.105.012161

February 23, 2005

    Article:
    • Dirk Daelemans,
    • Christophe Pannecouque,
    • George N Pavlakis,
    • Oriana Tabarrini,
    • and Erik De Clercq
    A novel and efficient approach to discriminate between pre- and post-transcription HIV inhibitors Mol Pharmacol ; published ahead of print February 23, 2005, doi:10.1124/mol.104.010249

February 22, 2005

    Article:
    • Guy Eelen,
    • Lieve Verlinden,
    • Natacha Rochel,
    • Frank Claessens,
    • Pierre De Clercq,
    • Maurits Vandewalle,
    • Giuseppe Tocchini-Valentini,
    • Dino Moras,
    • Roger Bouillon,
    • and Annemieke Verstuyf
    Superagonistic action of 14-epi-analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor - Coactivator Interaction Mol Pharmacol ; published ahead of print February 22, 2005, doi:10.1124/mol.104.008730
    Article:
    • Hugh C Hemmings, Jr,
    • Wayne Yan,
    • Robert I. Westphalen,
    • and Timothy A. Ryan
    The General Anesthetic Isoflurane Depresses Synaptic Vesicle Exocytosis Mol Pharmacol ; published ahead of print February 22, 2005, doi:10.1124/mol.104.003210

February 18, 2005

    Article:
    • Gracia Merino,
    • Antonius E. van Herwaarden,
    • Els Wagenaar,
    • Johan W. Jonker,
    • and Alfred H. Schinkel
    Gender-dependent expression and activity of the ABC transporter Breast Cancer Resistance Protein (BCRP/ABCG2) in liver Mol Pharmacol ; published ahead of print February 18, 2005, doi:10.1124/mol.105.011080
    Accelerated Communication:
    • Kalyan Pande,
    • Susan M. Moran,
    • and Christopher A. Bradfield
    Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines Mol Pharmacol ; published ahead of print February 18, 2005, doi:10.1124/mol.105.010983
    Article:
    • Joerg Zukunft,
    • Thomas Lang,
    • Tanja Richter,
    • Karen I Hirsch-Ernst,
    • Andreas K Nussler,
    • Kathrin Klein,
    • Matthias Schwab,
    • Michel Eichelbaum,
    • and Ulrich M. Zanger
    A natural CYP2B6 TATA box-polymorphism (-82T>C) leading to enhanced transcription and relocation of the transcriptional start site Mol Pharmacol ; published ahead of print February 18, 2005, doi:10.1124/mol.104.008086
    Article:
    • Jean-Marie Mangin,
    • Laurent Nguyen,
    • Catherine Gougnard,
    • Gregory Hans,
    • Bernard Rogister,
    • Shibeshih Belachew,
    • Gustave Moonen,
    • Pascal Legendre,
    • and Jean-Michel Rigo
    Developmental regulation of β-carboline-induced inhibition of glycine-evoked responses depends on glycine receptor β subunit expression Mol Pharmacol ; published ahead of print February 18, 2005, doi:10.1124/mol.104.007435

February 17, 2005

    Article:
    • Jan Balzarini,
    • Kristel Van Laethem,
    • Sigrid Hatse,
    • Matheus Froeyen,
    • Els Van Damme,
    • Anders Bolmstedt,
    • Willy Peumans,
    • Erik De Clercq,
    • and Dominique Schols
    MARKED DEPLETION OF GLYCOSYLATION SITES IN HIV-1 gp120 UNDER SELECTION PRESSURE BY THE MANNOSE-SPECIFIC PLANT LECTINS OF HIPPEASTRUM HYBRID AND GALANTHUS NIVALIS Mol Pharmacol ; published ahead of print February 17, 2005, doi:10.1124/mol.104.005082

February 16, 2005

    Article:
    • JEROME FAGART,
    • CENDRINE SEGUIN,
    • GREGORY-MAURICE PINON,
    • and Marie-Edith Rafestin-Oblin
    The Met852 residue is a key organizer of the ligand-binding cavity of the human mineralocorticoid receptor Mol Pharmacol ; published ahead of print February 16, 2005, doi:10.1124/mol.104.010710
    Article:
    • Gracia Merino,
    • Johan W. Jonker,
    • Els Wagenaar,
    • Antonius E. van Herwaarden,
    • and Alfred H. Schinkel
    The Breast Cancer Resistance Protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion and milk secretion of the antibiotic nitrofurantoin Mol Pharmacol ; published ahead of print February 11, 2005, doi:10.1124/mol.104.010439
    Article:
    • Guanghua Tang,
    • Lingyun Wu,
    • and Rui Wang
    The effect of hydroxylamine on KATP channels in vascular smooth muscle and underlying mechanisms Mol Pharmacol ; published ahead of print February 16, 2005, doi:10.1124/mol.104.008953
    Article:
    • Thomas Fahrig,
    • Irene Gerlach,
    • and Ervin Horvath
    A Synthetic Derivative of the Natural Product Rocaglaol is a Potent Inhibitor of Cytokine-Mediated Signaling and Shows Neuroprotective Activity In Vitro and in Animal Models of Parkinson's Disease and Traumatic Brain Injury Mol Pharmacol ; published ahead of print February 16, 2005, doi:10.1124/mol.104.008177
    Article:
    • Tim O Lankisch,
    • Arndt Vogel,
    • Stefan Eilermann,
    • Anette Fiebeler,
    • Britta Krone,
    • Ayse Barut,
    • Michael P. Manns,
    • and Christian P Strassburg
    IDENTIFICATION AND CHARACTERIZATION OF A FUNCTIONAL TATA BOX POLYMORPHISM OF THE UDP GLUCURONOSYLTRANSFERASE 1A7 GENE Mol Pharmacol ; published ahead of print February 16, 2005, doi:10.1124/mol.104.007146

February 15, 2005

    Perspective:
    • JoAnn Trejo
    Internal PDZ ligands: Novel Endocytic Recycling Motifs for G Protein-Coupled Receptors (Relates to Article by Paasche, et al., FastForward 15 February 2005) Mol Pharmacol ; published ahead of print February 15, 2005, doi:10.1124/mol.105.011288
    Article:
    • Joachim D. Paasche,
    • Toril Attramadal,
    • Kurt Kristiansen,
    • Morten P. Oksvold,
    • Heidi K. Johansen,
    • Henrik S. Huitfeldt,
    • Svein G. Dahl,
    • and Havard Attramadal
    Subtype-Specific Sorting of The ETA Endothelin Receptor by A Novel Endocytic Recycling Signal for G Protein-Coupled Receptors Mol Pharmacol ; published ahead of print February 15, 2005, doi:10.1124/mol.104.007013

February 14, 2005

    Article:
    • Samantha J Pitt,
    • Juan Martinez-Pinna,
    • Eric A Barnard,
    • and Martyn P Mahaut-Smith
    Potentiation of P2Y receptors by physiological elevations of extracellular K+ via a mechanism independent of Ca2+ influx Mol Pharmacol ; published ahead of print February 14, 2005, doi:10.1124/mol.104.009902
    Article:
    • Sun-Young Chang,
    • Hyun-Jeong Ko,
    • Tae-Hwe Heo,
    • and Chang-Yuil Kang
    Heparan Sulfate regulates the antiangiogenic activity of EMAP II at acidic pH Mol Pharmacol ; published ahead of print February 14, 2005, doi:10.1124/mol.104.008532
    Article:
    • Christopher S Kearn,
    • Katherine Blake-Palmer,
    • Emma Daniel,
    • Ken Mackie,
    • and Michelle Glass
    Concurrent Stimulation Of Cannabinoid CB1 And Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism For Receptor Crosstalk? Mol Pharmacol ; published ahead of print February 14, 2005, doi:10.1124/mol.104.006882

February 11, 2005

    Article:
    • Lizhen Yan,
    • James Herrington,
    • Ethan Goldberg,
    • Paula M Dulski,
    • Randal M Bugianesi,
    • Robert S Slaughter,
    • Priya Banerjee,
    • Richard M Brochu,
    • Birgit T Priest,
    • Gregory J Kaczorowski,
    • Bernardo Rudy,
    • and Maria L Garcia
    ShK, a Pharmacological Tool for Studying Kv3.2 Channels Mol Pharmacol ; published ahead of print February 11, 2005, doi:10.1124/mol.105.011064
    Article:
    • Yueming Huang and
    • Zhiyi Zuo
    Isoflurane induces a protein kinase C alpha-dependent increase in cell surface protein level and activity of glutamate transporter type 3 Mol Pharmacol ; published ahead of print February 11, 2005, doi:10.1124/mol.104.007443

February 10, 2005

    Article:
    • Ashley E. Brady,
    • Qin Wang,
    • Patrick B. Allen,
    • Mark Rizzo,
    • Paul Greengard,
    • and Lee E. Limbird
    Alpha2-adrenergic agonist enrichment of spinophilin at the cell surface involves βγ subunits of Gi proteins and is preferentially induced by the α2A-subtype Mol Pharmacol ; published ahead of print February 10, 2005, doi:10.1124/mol.104.005215
    Article:
    • Henry A. Charlier, Jr.,
    • Richard D. Olson,
    • Carissa M. Thornock,
    • Wendy K. Mercer,
    • David R. Olson,
    • T. Stephen Broyles,
    • Dawn J. Muhlestein,
    • Corianton L. Larson,
    • Barry J. Cusack,
    • and Susan E. Shadle
    Investigations of calsequestrin as a target for anthracyclines: comparison of functional effects of daunorubicin, daunorubicinol, and trifluoperazine Mol Pharmacol ; published ahead of print February 10, 2005, doi:10.1124/mol.104.005728

February 9, 2005

    Perspective:
    • Dianne M. Perez
    From Plants to Man: The GPCR "Tree of Life" (Relates to Article by Fredriksson, et al., FastForward 1 February 2005) Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.105.011890
    Perspective:
    • Joel Linden
    Adenosine in tissue protection and tissue regeneration (Relates to Article by Desai, et al., FastForward 26 January 2005) Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.105.011783
    Article:
    • Xiao-Feng Zhu,
    • Bin-Fen Xie,
    • Jun-Min Zhou,
    • Gong-Kan Feng,
    • Zong-chao liu,
    • Xiao-yi wei,
    • Feng-Xian Zhang,
    • Mei-Fang Liu,
    • and Yi-Xin Zeng
    Blockade of VEGF receptor signal pathway and antitumor activity of ON-III, a component from Chinese herbal medicine Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.009894
    Article:
    • Mingxiang Liao,
    • Victor A. Zgoda,
    • Bernard P. Murray,
    • and Maria Almira Correia
    VACUOLAR DEGRADATION OF RAT LIVER CYP2B1 IN SACCHAROMYCES CEREVISIAE: FURTHER VALIDATION OF THE YEAST MODEL AND STRUCTURAL IMPLICATIONS FOR THE DEGRADATION OF MAMMALIAN ENDOPLASMIC RETICULUM P450 PROTEINS Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.009654
    Article:
    • Mirella Belleri,
    • Domenico Ribatti,
    • Stefania Nicoli,
    • Franco Cotelli,
    • Luca Forti,
    • Vanio Vannini,
    • Lucia Anna Stivala,
    • and Marco Presta
    Antiangiogenic and vascular targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.009043
    Article:
    • Robert Fredriksson and
    • Helgi B. Schioth
    The repertoire of G-protein coupled receptors in fully sequenced genomes Mol Pharmacol ; published ahead of print February 1, 2005, doi:10.1124/mol.104.009001
    Article:
    • John A Allen,
    • Jiang Z Yu,
    • Robert J Donati,
    • and Mark M Rasenick
    β-Adrenergic Receptor Stimulation Promotes Gαs Internalization Through Lipid Rafts: A Study in Living Cells Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.008342
    Article:
    • HACK SUN CHOI,
    • CHEOL KYU HWANG,
    • CHUN SUNG KIM,
    • KYU YOUNG SONG,
    • PING-YEE LAW,
    • LI-LA WEI,
    • and HORACE H. LOH
    Transcriptional Regulation of Mouse µ Opioid Receptor Gene: Sp3 Isoforms (M1, M2) Function as Repressors in Neuronal Cells to Regulate the mu Opioid Receptor Gene Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.008284
    Article:
    • Philip E Chen,
    • Matthew T Geballe,
    • Phillip J Stansfeld,
    • Alexander R Johnston,
    • Hongjie Yuan,
    • Amanda L Jacob,
    • James P Snyder,
    • Stephen F Traynelis,
    • and David J A Wyllie
    Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.008185
    Article:
    • Makoto Osanai and
    • Martin Petkovich
    Expression of the Retinoic Acid Metabolizing Enzyme, CYP26A1 Limits Programmed Cell Death Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.005769
    Article:
    • Irina M. Muller,
    • Verena M. Dirsch,
    • Anita Rudy,
    • Nancy Lopez-Anton,
    • George R. Pettit,
    • and Angelika M. Vollmar
    Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.004234
    Article:
    • Francois Boudsocq,
    • Pierre Benaim,
    • Yvan Canitrot,
    • Martine Knibiehler,
    • Frederic Ausseil,
    • Jean-Pascal Capp,
    • Anne Bieth,
    • Christophe Long,
    • Bruno David,
    • Igor Shevelev,
    • Erika Frierich-Heinecken,
    • Ulrich Hubscher,
    • Francois Amalric,
    • Georges Massiot,
    • Jean-Sebastien Hoffmann,
    • and Christophe Cazaux
    Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase β Mol Pharmacol ; published ahead of print February 9, 2005, doi:10.1124/mol.104.001776

February 8, 2005

    Article:
    • Katrin Popowski,
    • Jyrki J. Eloranta,
    • Michael Saborowski,
    • Michael Fried,
    • Peter J. Meier,
    • and Gerd A. Kullak-Ublick
    The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4α and suppressed by bile acids Mol Pharmacol ; published ahead of print February 3, 2005, doi:10.1124/mol.104.010223

February 4, 2005

    Article:
    • Jian-Mei Li,
    • Masaru Iwai,
    • Tai-Xing Cui,
    • Li-Juan Min,
    • Masahiro Tsuda,
    • Jun Iwanami,
    • Jun Suzuki,
    • Masaki Mogi,
    • and Masatsugu Horiuchi
    Effect of Azelnidipine on Angiotensin II-mediated Growth-promoting Signaling in Vascular Smooth Muscle Cells Mol Pharmacol ; published ahead of print February 4, 2005, doi:10.1124/mol.104.008144
    Article:
    • Dario Bonanomi,
    • Maria Pennuto,
    • Michela Rigoni,
    • Ornella Rossetto,
    • Cesare Montecucco,
    • and Flavia Valtorta
    Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2 Mol Pharmacol ; published ahead of print February 4, 2005, doi:10.1124/mol.104.005678

February 3, 2005

    Article:
    • Debbie L Hay,
    • George Christopoulos,
    • Arthur Christopoulos,
    • D. R. Poyner,
    • and Patrick M. Sexton
    Pharmacological discrimination of calcitonin receptor - receptor activity modifying protein complexes Mol Pharmacol ; published ahead of print February 3, 2005, doi:10.1124/mol.104.008615
    Article:
    • Christian Watson,
    • Stephen Jenkinson,
    • Wieslaw Kazmierski,
    • and Terry P Kenakin
    The CCR5 Receptor-based mechanism of action of 873140, a potent allosteric non-competitive HIV entry-inhibitor Mol Pharmacol ; published ahead of print January 11, 2005, doi:10.1124/mol.104.008565

February 2, 2005

    Accelerated Communication:
    • Orazio Cantoni,
    • Andrea Guidarelli,
    • Letizia Palomba,
    • and Mara Fiorani
    U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism Mol Pharmacol ; published ahead of print February 2, 2005, doi:10.1124/mol.104.009498
    Article:
    • Britta J. Eickholt,
    • Greg Towers,
    • W. Jonathan Ryves,
    • Daniel Eikel,
    • Kathryn Adley,
    • Lili Ylinen,
    • Neil Chadborn,
    • Adrian Harwood,
    • Heinz Nau,
    • and Robin sb Williams
    Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, GSK-3β inhibition and viral replication - A screening approach for new bipolar disorder drugs based on the valproic acid core structure Mol Pharmacol ; published ahead of print February 1, 2005, doi:10.1124/mol.104.009308
    Article:
    • Evgeni Ponimaskin,
    • Aline Dumuis,
    • Florence Gaven,
    • Gael Barthet,
    • Martin Heine,
    • Konstantin Glebov,
    • Diethelm W. Richter,
    • and Martin Oppermann
    Palmitoylation of the 5-Hydroxytryptamine(4a) Receptor Regulates Receptor Phosphorylation, Desensitization and βArrestin mediated Endocytosis Mol Pharmacol ; published ahead of print February 2, 2005, doi:10.1124/mol.104.008748

February 1, 2005

    Article:
    • Viktor Yarotskyy,
    • Alexander V Glushakov,
    • Colin Sumners,
    • Nikolaus Gravenstein,
    • Donn M Dennis,
    • Christoph N Seubert,
    • and Anatoly E Martynyuk
    Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine Mol Pharmacol ; published ahead of print February 1, 2005, doi:10.1124/mol.104.005983

January 31, 2005

    Article:
    • Christian Feisst,
    • Dana Albert,
    • Dieter Steinhilber,
    • and Oliver Werz
    The aminosteroid phospholipase C antagonist U-73122 potently inhibits human 5-lipoxygenase in vivo and in vitro Mol Pharmacol ; published ahead of print January 31, 2005, doi:10.1124/mol.105.011007
    Article:
    • Armando Ialenti,
    • Gianluca Grassia,
    • Paola Di Meglio,
    • Pasquale Maffia,
    • Massimo Di Rosa,
    • and Angela Ianaro
    Mechanism of the anti-inflammatory effect of thiazolidindiones. Relationship with the glucocorticoid pathway Mol Pharmacol ; published ahead of print January 31, 2005, doi:10.1124/mol.104.004895

January 28, 2005

    Article:
    • Albert Lai,
    • Neeraja Parameswaran,
    • Mirium Khwaja,
    • Paul Whiteaker,
    • Jon M Lindstrom,
    • Hong Fan,
    • J Michael McIntosh,
    • Sharon R Grady,
    • and Maryka Quik
    Chronic nicotine treatment decreases striatal α6* nAChR sites and function in mice Mol Pharmacol ; published ahead of print January 28, 2005, doi:10.1124/mol.104.006429
    Article:
    • Lenka L Allan and
    • David H Sherr
    Constitutive Activation and Environmental Chemical Induction of the Aryl Hydrocarbon Receptor/Transcription Factor (AhR) in Activated Human B Lymphocytes Mol Pharmacol ; published ahead of print January 28, 2005, doi:10.1124/mol.104.009100

January 26, 2005

    Perspective:
    • Lee E. Eiden
    Fusion Polypeptides That Inhibit Exocytosis: Fusing Aptamer and Cell Penetrating Peptide Technologies and Pharmacologies (Relates to Article by Matsushita, et al., FastForward 17 December 2004) Mol Pharmacol ; published ahead of print January 26, 2005, doi:10.1124/mol.105.011429
    Perspective:
    • Delphine Baetz,
    • James Shaw,
    • and Lorrie A Kirshenbaum
    Nuclear Factor-κB Decoys Suppresses Endotoxin- Induced Lung Injury (Relates to Article by Matsuda, et al., FastForward 2 December 2004) Mol Pharmacol ; published ahead of print January 26, 2005, doi:10.1124/mol.105.011296
    Article:
    • Avani D Desai,
    • Cassandre Victor-Vega,
    • Swathi Gadangi,
    • M. Carmen Montesinos,
    • Charles C Chu,
    • and Bruce N Cronstein
    Adenosine A2A Receptor Stimulation Increases Angiogenesis By Downregulating Production Of The Anti-Angiogenic Matrix Protein Thrombospondin 1 (TSP1) Mol Pharmacol ; published ahead of print January 26, 2005, doi:10.1124/mol.104.007807

January 21, 2005

    Article:
    • Christine Beeton,
    • Michael W. Pennington,
    • Heike Wulff,
    • Satendra Singh,
    • Daniel Nugent,
    • George Crossley,
    • Ilya Khaytin,
    • Peter A. Calabresi,
    • Chao-Yin Chen,
    • George A. Gutman,
    • and K. George Chandy
    Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases Mol Pharmacol ; published ahead of print January 21, 2005, doi:10.1124/mol.104.008193
    Article:
    • Ricardo A. Garcia,
    • Dennis P. Pantazatos,
    • Christopher R. Gessner,
    • Katrina V. Go,
    • Virgil L. Woods, Jr.,
    • and Francisco J. Villarreal
    Molecular Interactions Between Matrilysin and the Matrix Metalloproteinase Inhibitor Doxycycline Investigated by Deuterium Exchange Mass Spectrometry Mol Pharmacol ; published ahead of print January 21, 2005, doi:10.1124/mol.104.006346

January 20, 2005

    Accelerated Communication:
    • Thomas V. Wuttke,
    • Guiscard Seebohm,
    • Sigrid Bail,
    • Snezana Maljevic,
    • and Holger Lerche
    The new anticonvulsant Retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate Mol Pharmacol ; published ahead of print January 20, 2005, doi:10.1124/mol.104.010793
    Article:
    • Kevin R Hayes,
    • Aaron L Vollrath,
    • Gina M Zastrow,
    • Brian J McMillan,
    • Mark W Craven,
    • Stevan B Jovanovich,
    • Jacqueline A Walisser,
    • Dave R Rank,
    • Sharon G Penn,
    • Janardan K. Reddy,
    • Russell S Thomas,
    • and Christopher A. Bradfield
    EDGE: A Centralized Resource for the Comparison, Analysis and Distribution of Toxicogenomic Information Mol Pharmacol ; published ahead of print January 20, 2005, doi:10.1124/mol.104.009175
    Article:
    • Christian Popp,
    • Valentin Gorboulev,
    • Thomas Muller,
    • Dmitry Gorbunov,
    • Natalia Shatskaya,
    • and Hermann Koepsell
    Amino Acids Critical for Substrate Affinity of Rat Organic Cation Transporter 1 Line the Substrate Binding Region in a Model Derived from the Tertiary Structure of Lactose Permease Mol Pharmacol ; published ahead of print January 20, 2005, doi:10.1124/mol.104.008839
    Article:
    • Valentin Gorboulev,
    • Natalia Shatskaya,
    • Christopher Volk,
    • and Hermann Koepsell
    Subtype-specific Affinity for Corticosterone of Rat Organic Cation Transporters rOCT1 and rOCT2 Depends on Three Amino Acids within the Substrate Binding Region Mol Pharmacol ; published ahead of print January 20, 2005, doi:10.1124/mol.104.008821
    Article:
    • Peijin Zhang,
    • Xianbin Tian,
    • Priyamvada Chandra,
    • and Kim L. Brouwer
    Role of Glycosylation in Trafficking of Mrp2 in Sandwich- Cultured Rat Hepatocytes Mol Pharmacol ; published ahead of print January 20, 2005, doi:10.1124/mol.104.004481

January 18, 2005

    Article:
    • Ilan Ifergan,
    • Gerrit Jansen,
    • and Yehuda G. Assaraf
    Cytoplasmic Confinement of Breast Cancer Resistance Protein (BCRP/ABCG2) as a Novel Mechanism of Adaptation to Short-Term Folate Deprivation Mol Pharmacol ; published ahead of print January 18, 2005, doi:10.1124/mol.104.008250
    Accelerated Communication:
    • Roland Baur and
    • Erwin Sigel
    Benzodiazepines Affect Channel Opening of GABAA Receptors Induced by Either Agonist Binding Site Mol Pharmacol ; published ahead of print January 18, 2005, doi:10.1124/mol.104.008151
    Article:
    • Satu Arpiainen,
    • Francoise Raffalli-Mathieu,
    • Matti A. Lang,
    • Olavi Pelkonen,
    • and Jukka Hakkola
    Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor dependent pathway Mol Pharmacol ; published ahead of print January 18, 2005, doi:10.1124/mol.104.008078

January 13, 2005

    Article:
    • Jui-Wen Huang,
    • Chung-Wai Shiau,
    • Ya-Ting Yang,
    • Samuel K. Kulp,
    • Kuen-Feng Chen,
    • Robert W. Brueggemeier,
    • Charles L. Shapiro,
    • and Ching-Shih Chen
    Peroxisome Proliferator-Activated Receptor γ-Independent Ablation of Cyclin D1 by Thiazolidenediones and Their Derivatives in Breast Cancer Cells Mol Pharmacol ; published ahead of print January 13, 2005, doi:10.1124/mol.104.007732
    Article:
    • Laurent DUCA,
    • Elise LAMBERT,
    • Romain DEBRET,
    • Bernard ROTHHUT,
    • Charlotte BLANCHEVOYE,
    • Frederic DELACOUX,
    • William HORNEBECK,
    • Laurent MARTINY,
    • and Laurent DEBELLE
    Elastin peptides activate ERK1/2 via a Ras-independent mechanism requiring both p110γ/Raf-1 and PKA/B-Raf signaling in human skin fibroblasts Mol Pharmacol ; published ahead of print January 13, 2005, doi:10.1124/mol.104.002725

January 11, 2005

    Article:
    • Gang Lu,
    • Dorian Henderson,
    • Lieju Liu,
    • Peter H Reinhart,
    • and Sidney A Simon
    TRPV1b: a Functional Human Vanilloid Receptor Splice Variant Mol Pharmacol ; published ahead of print January 11, 2005, doi:10.1124/mol.104.009852
    Article:
    • Julien DAIROU,
    • Francois MALECAZE,
    • Jean-Marie DUPRET,
    • and Fernando RODRIGUES-LIMA
    The Xenobiotic-metabolizing Enzymes Arylamine N-acetyltransferases (NAT) in Human Lens Epithelial Cells: Inactivation by Cellular Oxidants and UVB-induced Oxidative Stress Mol Pharmacol ; published ahead of print January 11, 2005, doi:10.1124/mol.104.009738
    Article:
    • Chun-Ling Sun and
    • Chuck C.-K. Chao
    Cross-Resistance to Death Ligand-Induced Apoptosis in Cisplatin-Selected HeLa Cells Associated with Overexpression of DDB2 and Subsequent Induction of cFLIP Mol Pharmacol ; published ahead of print January 11, 2005, doi:10.1124/mol.104.008797
    Article:
    • Rym Barbouche,
    • Hugues Lortat-Jacob,
    • Ian M Jones,
    • and Emmanuel Fenouillet
    Glycosaminoglycans and Protein Disulfide Isomerase-Mediated Reduction of HIV Env Mol Pharmacol ; published ahead of print January 11, 2005, doi:10.1124/mol.104.008276
    Article:
    • Mauro Federici,
    • Raffaella Geracitano,
    • Alessandro Tozzi,
    • Patrizia Longone,
    • Silvia DiAngelantonio,
    • Peter Bengtson,
    • Giorgio Bernardi,
    • and Nicola Biagio Mercuri
    Trace amines depress GABAB response in dopaminergic neurons by inhibiting GIRK channels Mol Pharmacol ; published ahead of print January 11, 2005, doi:10.1124/mol.104.007427
    Article:
    • Frank Visser,
    • Jing Zhang,
    • R. Taylor Raborn,
    • Stephen A Baldwin,
    • James D Young,
    • and Carol E Cass
    Residue 33 of Human Equilibrative Nucleoside Transporter 2 is a Functionally Important Component of Both the Dipyridamole and Nucleoside Binding Sites Mol Pharmacol ; published ahead of print January 11, 2005, doi:10.1124/mol.104.005884

January 7, 2005

    Article:
    • Wendy M. Suhre,
    • Sean Ekins,
    • Cheng Chang,
    • Peter W. Swaan,
    • and Stephen H. Wright
    Molecular Determinants of Substrate/Inhibitor Binding to the Human and Rabbit Renal Organic Cation Transporters, hOCT2 and rbOCT2 Mol Pharmacol ; published ahead of print January 3, 2005, doi:10.1124/mol.104.004713
    Article:
    • Dacia L Hunton,
    • William G. Barnes,
    • Jihee Kim,
    • Xiu-Rong Ren,
    • Jonathan D. Violin,
    • Eric Reiter,
    • Graeme Milligan,
    • Dhavalkumar D. Patel,
    • and Robert J. Lefkowitz
    β-arrestin 2 Dependent AT1A Receptor Mediated Pathway of Chemotaxis Mol Pharmacol ; published ahead of print January 5, 2005, doi:10.1124/mol.104.006270
    Accelerated Communication:
    • John Daniel Pediani,
    • Janet Fraser Colston,
    • Darren Caldwell,
    • Graeme Milligan,
    • Craig James Daly,
    • and John Christie McGrath
    β-arrestin Dependent Spontaneous α1a-Adrenoceptor Endocytosis causes Intracellular Transportation of α-blockers via Recycling Compartments Mol Pharmacol ; published ahead of print December 30, 2004, doi:10.1124/mol.104.008417

January 5, 2005

    Article:
    • Mary A. Bittner and
    • Ronald W. Holz
    PIP2:ACTIN DYNAMICS AND THE REGULATION OF ATP-DEPENDENT AND -INDEPENDENT SECRETION Mol Pharmacol ; published ahead of print January 5, 2005, doi:10.1124/mol.104.008474
    Article:
    • Andrea Barberis,
    • Congyi Lu,
    • Stefano Vicini,
    • and Jerzy W Mozrzymas
    Developmental Changes of GABA Synaptic Transient in Cerebellar Granule Cells Mol Pharmacol ; published ahead of print January 5, 2005, doi:10.1124/mol.104.006437
    Article:
    • Hai-Lin Fang,
    • Stephen C. Strom,
    • Hongbo Cai,
    • Charles N. Falany,
    • Thomas A. Kocarek,
    • and Melissa Runge-Morris
    Regulation of Human Hepatic Hydroxysteroid Sulfotransferase Gene Expression by the Peroxisome Proliferator Activated Receptor Alpha Transcription Factor Mol Pharmacol ; published ahead of print January 5, 2005, doi:10.1124/mol.104.005389
    Article:
    • Jian Hua Li,
    • Han Choe,
    • Ai Fen Wang,
    • Kaushik Maiti,
    • Chenbing Wang,
    • Md Abdus Salam,
    • Sang Young Chun,
    • Won-Kyo Lee,
    • Kyungjin Kim,
    • Hyuk Bang Kwon,
    • and Jae Young Seong
    Extracellular Loop 3 (EL3) and EL3-Proximal Transmembrane Helix 7 of the Mammalian Type I and Type II GnRH Receptors Determine Differential Ligand Selectivity to GnRH-I and GnRH-II Mol Pharmacol ; published ahead of print January 5, 2005, doi:10.1124/mol.104.004887

January 4, 2005

    Article:
    • Zonghe Yan,
    • Zhaodong Liang,
    • Melanija Tomic,
    • Tomas Obsil,
    • and Stanko S. Stojilkovic
    Molecular determinants of the agonist binding domain of a P2X receptor-channel Mol Pharmacol ; published ahead of print January 4, 2005, doi:10.1124/mol.104.010108
    Article:
    • Anthony Collins,
    • Haoran Wang,
    • and Maureen Larson
    Differential sensitivity of Kir2 inward rectifier potassium channels to a mitochondrial uncoupler: identification of a regulatory site Mol Pharmacol ; published ahead of print January 4, 2005, doi:10.1124/mol.104.008292

January 3, 2005

    Article:
    • Daniele Lacasa,
    • Nicolas Boute,
    • and Tarik Issad
    INTERACTION OF THE INSULIN RECEPTOR WITH THE RECEPTOR-LIKE PROTEIN TYROSINE-PHOSPHATASES PTPα and PTP<IMG SRC="/math/epsi.gif" ALT="{epsilon}"> IN LIVING CELLS Mol Pharmacol ; published ahead of print January 3, 2005, doi:10.1124/mol.104.009514
    Article:
    • Marta Enguita,
    • Nuria DeGregorio-Rocasolano,
    • Alba Abad,
    • and Ramon Trullas
    Glycogen synthase kinase 3 activity mediates neuronal pentraxin 1 expression and cell death induced by potassium deprivation in cerebellar granule cells Mol Pharmacol ; published ahead of print January 3, 2005, doi:10.1124/mol.104.007062
    Article:
    • Jessica A Bonzo,
    • Shujuan Chen,
    • Alema Galijatovic,
    • and Robert H Tukey
    Arsenite Inhibition of CYP1A1 Induction by TCDD is Independent of Cell Cycle Arrest Mol Pharmacol ; published ahead of print January 3, 2005, doi:10.1124/mol.104.006130

December 30, 2004

    Article:
    • Martijn Bruysters,
    • Aldo Jongejan,
    • Michel Gillard,
    • Frank van de Manakker,
    • Remko A. Bakker,
    • Pierre Chatelain,
    • and Rob Leurs
    Pharmacological differences between human and guinea pig histamine H1 receptors: Asn84 (2.61) as key residue within an additional binding pocket in the H1 receptor Mol Pharmacol ; published ahead of print December 30, 2004, doi:10.1124/mol.104.008847
    Article:
    • Eddy H.T. Wu and
    • Yung H. Wong
    Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells and cortical neurons Mol Pharmacol ; published ahead of print December 30, 2004, doi:10.1124/mol.104.007237

December 29, 2004

    Accelerated Communication:
    • Maud Deraet,
    • Philippe Manivet,
    • Agnes Janoshazi,
    • Jacques Callebert,
    • Silke Guenther,
    • Ludovic Drouet,
    • Jean-Marie Launay,
    • and Luc Maroteaux
    The natural mutation encoding a C-terminus truncated 5-HT2B receptor is a gain of proliferative functions Mol Pharmacol ; published ahead of print December 29, 2004, doi:10.1124/mol.104.008268
    Article:
    • Mohamed Rahmani,
    • Erin Reese,
    • Yun Dai,
    • Cheryl Bauer,
    • Lora B Kramer,
    • Mei Huang,
    • Richard Jove,
    • Paul Dent,
    • and Steven Grant
    Co-treatment with SAHA and 17-AAG synergistically induces apoptosis in Bcr-Abl+ cells sensitive and resistant to STI-571 in association with down-regulation of Bcr-Abl, abrogation of STAT5 activity, and Bax conformational change Mol Pharmacol ; published ahead of print December 29, 2004, doi:10.1124/mol.104.007831
    Article:
    • Jamal TAZI,
    • Nadia Bakkour,
    • Johann Soret,
    • Latifa Zekri,
    • Banasri Hazra,
    • William Laine,
    • Brigitte Baldeyrou,
    • Amelie Lansiaux,
    • and Christian Bailly
    Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives Mol Pharmacol ; published ahead of print December 29, 2004, doi:10.1124/mol.104.007633
    Article:
    • Soma Rakhit,
    • Catherine J Clark,
    • Celestine T O'Shaughnessy,
    • and Brian J. Morris
    NMDA and BDNF induce distinct profiles of Extracellular regulated kinase (ERK), Mitogen and stress activated kinase (MSK) and Ribosomal S6 kinase (RSK) phosphorylation in cortical neurones Mol Pharmacol ; published ahead of print December 29, 2004, doi:10.1124/mol.104.005447
    Article:
    • ALATANGAOLE DAMIRIN,
    • HIDEAKI TOMURA,
    • MAYUMI KOMACHI,
    • MASAYUKI TOBO,
    • KOICHI SATO,
    • CHIHIRO MOGI,
    • HIROMI NOCHI,
    • KOICHI TAMOTO,
    • and FUMIKAZU OKAJIMA
    Sphingosine-1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation Through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells Mol Pharmacol ; published ahead of print December 29, 2004, doi:10.1124/mol.104.004317

December 22, 2004

    Article:
    • Christophe Moreau,
    • Fabienne Gally,
    • Helene Jacquet-Bouix,
    • and Michel Vivaudou
    The size of a single residue of the sulfonylurea receptor dictates the effectiveness of KATP channel openers Mol Pharmacol ; published ahead of print December 22, 2004, doi:10.1124/mol.104.008698
    Accelerated Communication:
    • monika niehof and
    • Jurgen Borlak
    RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain Mol Pharmacol ; published ahead of print December 22, 2004, doi:10.1124/mol.104.008672
    Article:
    • Miklos Bagdany,
    • Cesar V.F. Batista,
    • Norma A Valdez-Cruz,
    • Sandor Somodi,
    • Ricardo C. Rodriguez de la Vega,
    • Alexei F Licea,
    • Zoltan Varga,
    • Rezso Gaspar,
    • Lourival D. Possani,
    • and Gyorgy Panyi
    Anuroctoxin, a new scorpion toxin of the α-KTx 6 subfamily is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes Mol Pharmacol ; published ahead of print December 22, 2004, doi:10.1124/mol.104.007187
    Article:
    • Sanjay Kansra,
    • Stefan W. Stoll,
    • Jessica L. Johnson,
    • and James T. Elder
    Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes Mol Pharmacol ; published ahead of print December 22, 2004, doi:10.1124/mol.104.004689

December 21, 2004

    Article:
    • Patrick S Mangan,
    • Chengsan Sun,
    • Mackenzie Carpenter,
    • Howard P Goodkin,
    • Werner Sieghart,
    • and Jaideep Kapur
    CULTURED HIPPOCAMPAL PYRAMIDAL NEURONS EXPRESS TWO KINDS OF GABAA RECEPTORS Mol Pharmacol ; published ahead of print December 21, 2004, doi:10.1124/mol.104.007385

December 20, 2004

    Article:
    • Tomohiko Kanayama,
    • Naoki Kobayashi,
    • Satoru Mamiya,
    • Tsuyoshi Nakanishi,
    • and Jun-ichi Nishikawa
    Organotin compounds promote adipocute differentiation as agonists of the peroxisome proliferator-activated receptor (PPAR) γ / retinoid X receptor (RXR) pathway Mol Pharmacol ; published ahead of print December 20, 2004, doi:10.1124/mol.104.008409
    Article:
    • Shuso Takeda,
    • Yuji Ishii,
    • Megumi Iwanaga,
    • Peter I Mackenzie,
    • Kiyoshi Nagata,
    • Yasushi Yamazoe,
    • Kazuta Oguri,
    • and Hideyuki Yamada
    Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4 Mol Pharmacol ; published ahead of print December 20, 2004, doi:10.1124/mol.104.007641

December 17, 2004

    Perspective:
    • Guiscard Seebohm
    Activators of Cation Channels (Relates to Article by Kang, et al., FastForward 17 November 2004) Mol Pharmacol ; published ahead of print December 17, 2004, doi:10.1124/mol.104.010173
    Accelerated Communication:
    • Takaaki Hiragun,
    • Ze Peng,
    • and Michael A. Beaven
    Dexamethasone Upregulates the Inhibitory Adaptor Protein, Dok-1, and Suppresses Downstream Activation of the Mitogen-Activated Protein Kinase Pathway in Antigen-Stimulated RBL-2H3 Mast Cells Mol Pharmacol ; published ahead of print December 17, 2004, doi:10.1124/mol.104.008607
    Article:
    • Kurt Watson and
    • Guo-Huang Fan
    MIP-2 inhibits β-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen activated protein kinase and phosphatidylinositol 3-kinase signaling pathways Mol Pharmacol ; published ahead of print December 17, 2004, doi:10.1124/mol.104.004812
    Article:
    • Catherine Mollereau,
    • Honore Mazarguil,
    • Jean-Marie Zajac,
    • and Michel Roumy
    NPFF analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells Mol Pharmacol ; published ahead of print December 17, 2004, doi:10.1124/mol.104.004614
    Article:
    • Kenji Matsushita,
    • Craig N. Morrell,
    • and Charles J. Lowenstein
    A Novel Class of Fusion Polypeptides Inhibits Exocytosis Mol Pharmacol ; published ahead of print December 17, 2004, doi:10.1124/mol.104.004275

December 16, 2004

    Perspective:
    • Olivier Civelli
    An orphan receptor adopted by a family of transmitters (Relates to article by Wellendorph, et al., FastForward 2 December 2004) Mol Pharmacol ; published ahead of print December 16, 2004, doi:10.1124/mol.104.010348
    Article:
    • Thomas P Burris,
    • Chahrzad Montrose,
    • Keith A Houck,
    • Harold E Osborne,
    • Wayne P Bocchinfuso,
    • Benjamin C. Yaden,
    • Christine C Cheng,
    • Richard W Zink,
    • Robert J Barr,
    • Christopher D Hepler,
    • Venkatesh Krishnan,
    • Heather A Bullock,
    • Lorri L Burris,
    • Rachelle J Galvin,
    • Kelli S Bramlett,
    • and Keith R Stayrook
    The Hypolipidemic Natural Product Guggulsterone is a Promiscuous Steroid Receptor Ligand Mol Pharmacol ; published ahead of print December 15, 2004, doi:10.1124/mol.104.007054
    Article:
    • Simone Gorzalka,
    • Sauro Vittori,
    • Rosaria Volpini,
    • Gloria Cristalli,
    • Ivar von Kugelgen,
    • and Christa E Muller
    Evidence for the Functional Expression and Pharmacological Characterization of Adenine Receptors in Native Cells and Tissues Mol Pharmacol ; published ahead of print December 16, 2004, doi:10.1124/mol.104.006601

December 15, 2004

    Article:
    • Masuo Kondoh,
    • Akane Masuyama,
    • Azusa Takahashi,
    • Nagayoshi Asano,
    • Hiroyuki Mizuguchi,
    • Naoya Koizumi,
    • Makiko Fujii,
    • Takao Hayakawa,
    • Yasuhiko Horiguchi,
    • and Yoshiteru Watanabe
    A novel strategy for the enhancement of drug absorption using a claudin modulator Mol Pharmacol ; published ahead of print December 15, 2004, doi:10.1124/mol.104.008375
    Article:
    • Peter Kometiani,
    • Lijun Liu,
    • and Amir Askari
    Digitalis-Induced Signaling by Na+/K+-ATPase in Human Breast Cancer Cells Mol Pharmacol ; published ahead of print December 15, 2004, doi:10.1124/mol.104.007302
    Article:
    • Anthony Baurand,
    • Anita Eckly,
    • Beatrice Hechler,
    • Gilles Kauffenstein,
    • Jean-Luc Galzi,
    • Jean-Pierre Cazenave,
    • Catherine Leon,
    • and Christian Gachet
    Differential regulation and relocalization of the platelet P2Y receptors following activation : a way to avoid loss of hemostatic properties? Mol Pharmacol ; published ahead of print December 15, 2004, doi:10.1124/mol.104.004846
    Article:
    • Brian B. Hasinoff,
    • Xing Wu,
    • Oleg V. Krokhin,
    • Werner Ens,
    • Kenneth G. Standing,
    • John L. Nitiss,
    • Tejomoortula Sivaram,
    • Angela Giorgianni,
    • Shaohua Yang,
    • Yu Jiang,
    • and Jack C. Yalowich
    Biochemical and Proteomics Approaches to Characterize Topoisomerase IIα Cysteines and DNA as Targets Responsible for Cisplatin-induced Inhibition of Topoisomerase IIα Mol Pharmacol ; published ahead of print December 15, 2004, doi:10.1124/mol.104.004416

December 14, 2004

    Article:
    • Garet P Lahvis,
    • Robert W Pyzalski,
    • Edward Glover,
    • Henry C Pitot,
    • Matthew K McElwee,
    • and Christopher A. Bradfield
    The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse Mol Pharmacol ; published ahead of print December 8, 2004, doi:10.1124/mol.104.008888
    Article:
    • Chihiro Hosoda,
    • Taka-aki Koshimizu,
    • Akito Tanoue,
    • Yoshihisa Nasa,
    • Ryo Oikawa,
    • Takashi Tomabechi,
    • Shinya Fukuda,
    • Hitomi Shinoura,
    • Sayuri Oshikawa,
    • Satoshi Takeo,
    • Tadaichi Kitamura,
    • Susanna Cotecchia,
    • and Gozoh Tsujimoto
    Two α1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation Mol Pharmacol ; published ahead of print December 14, 2004, doi:10.1124/mol.104.007500
    Article:
    • Yasuhisa Adachi,
    • Hiroshi Suzuki,
    • Alfred H. Schinkel,
    • and Yuichi Sugiyama
    Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen Mol Pharmacol ; published ahead of print December 14, 2004, doi:10.1124/mol.104.007393
    Article:
    • Asher Peretz,
    • Nurit Degani,
    • Rachel Nachman,
    • Yael Uziyel,
    • Gilad Gibor,
    • Doron Shabat,
    • and Bernard Attali
    Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties Mol Pharmacol ; published ahead of print December 14, 2004, doi:10.1124/mol.104.007112
    Article:
    • Martin Bartsch,
    • Alida Weeke-Klimp,
    • Henriette W.M. Morselt,
    • Andrea Kimpfler,
    • Sigridur A Asgeirsdottir,
    • Rolf Schubert,
    • Dirk K.F. Meijer,
    • Gerrit L. Scherphof,
    • and Jan A.A.M. Kamps
    Optimized targeting of PEG-stabilized anti-ICAM-1 ODN/lipid particles to liver sinusoidal endothelial cells Mol Pharmacol ; published ahead of print December 14, 2004, doi:10.1124/mol.104.004523
    Article:
    • Karin F.K. Ejendal and
    • Christine A. Hrycyna
    Differential Sensitivities of the Human ABC Transporters ABCG2 and P-glycoprotein to Cyclosporin A Mol Pharmacol ; published ahead of print December 14, 2004, doi:10.1124/mol.104.001701

December 10, 2004

    Article:
    • Ashish S. Verma,
    • Ravindra N. Dhir,