T-cell protein tyrosine phosphatase (TCPTP) is irreversibly inhibited by etoposide-quinone, a reactive metabolite of the chemotherapy drug etoposide

Data Supplement

• Supplemental Data -

  Supplementary Methods

  Supplementary Figure 1 - Determination of EQ IC50 for Human TCPTP inhibition

  Supplementary Figure 2 - ETOP activated to EQ by myeloperoxidase inhibits TCPTP activity

  Supplementary Figure 3 - ETOP activated to EQ by myeloperoxidase inhibits TCPTP activity

  Supplementary Figure 4 - Effect of ETOP and EQ on PTP1B activity

  Supplementary References