Characterization and optimization of the novel TRPM2 antagonist tatM2NX

Data Supplement

• Supplemental Data -

  Supplementary Figure 1 - TRPM2 protein is expressed and functional in doxycycline-inducible HEK293 cells.

  Supplementary Figure 2 - Molecular modeling of tat Cterm and tatWV-AA with human TRPM2 channel NUDT9-H domain.

  Supplementary Figure 3 - No changes in ADPRi current density or frequency distribution in Ca2+ fluorescence in the presence of peptides.

  Supplementary Table 1 - tat Cterm non-covalent interactions.