Data Supplement
- Supplemental Data -
Supplementary Table 1 - Coordinates of the docking box centroids.
Supplementary Figure 1 - Sequence alignment for human ρ1 (accession code P24046), human β3 (P28472), and the GLIC-α1 chimeric subunits (Laverty et al., 2017, Nat Struct Mol Biol 24:977-985).
- Supplemental Data -
Supplementary Figure 2 - The model of the human ρ1 receptor (accession code P24046) was built based on homology with the human β3 structure (PDB ID: 4COF) and the GLIC-α1 chimeric receptor (PDB ID: 5OSB). Insert link to rho1_pentamer.pdb
- Supplemental Data -
Supplementary Figure 3 - Docking of 3α5βP, 3α5βPS, β-estradiol, and 5αTHDOC to the intersubunit site located at the interface between Chains B and A (Site I; Hosie et al., 2006, Nature 444:486-489). Insert link to SiteI-poses.pdb
- Supplemental Data -
Supplementary Figure 4 - Docking of 3α5βP, 3α5βPS, β-estradiol, and 5αTHDOC to the intrasubunit site near the interface between membrane-spanning and extracellular domains on Chain A (Site II; Chen et al., 2019, PLoS Biol 17:e3000157). Insert link to SiteII-poses.pdb
- Supplemental Data -
Supplementary Figure 5 - Docking of 3α5βP, 3α5βPS, β-estradiol, and 5αTHDOC to the intrasubunit site near the cytoplasmic end of TM3 and TM4 domains on Chain A (Site III; Laverty et al., 2017, Nat Struct Mol Biol 24:977-985). Insert link to SiteIII-poses.pdb