Table of Contents

Articles

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  Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model

  Wassana Wijagkanalan, Yuriko Higuchi, Shigeru Kawakami, Mugen Teshima, Hitoshi Sasaki and Mitsuru Hashida

  Molecular Pharmacology November 2008, 74 (5) 1183-1192; DOI: https://doi.org/10.1124/mol.108.050153
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  Identification of a Putative Intracellular Allosteric Antagonist Binding-Site in the CXC Chemokine Receptors 1 and 2

  David J. Nicholls, Nick P. Tomkinson, Katherine E. Wiley, Anne Brammall, Lorna Bowers, Caroline Grahames, Alasdair Gaw, Premji Meghani, Philip Shelton, Tracey J. Wright and Philip R. Mallinder

  Molecular Pharmacology November 2008, 74 (5) 1193-1202; DOI: https://doi.org/10.1124/mol.107.044610
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  1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) Selectively Inhibits Kir3 and BK Channels in a Phospholipase C-Independent Fashion

  Angelika Klose, Tobias Huth and Christian Alzheimer

  Molecular Pharmacology November 2008, 74 (5) 1203-1214; DOI: https://doi.org/10.1124/mol.108.047837
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  Dynamic Effect of Bortezomib on Nuclear Factor-κB Activity and Gene Expression in Tumor Cells

  Myong-Hee Sung, Lorena Bagain, Zhong Chen, Tatiana Karpova, Xinping Yang, Christopher Silvin, Ty C. Voss, James G. McNally, Carter Van Waes and Gordon L. Hager

  Molecular Pharmacology November 2008, 74 (5) 1215-1222; DOI: https://doi.org/10.1124/mol.108.049114
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  Differential Signaling Pathways in Angiotensin II- and Epidermal Growth Factor-stimulated Hepatic C9 Cells

  Xing Yin, Bo Li, Hungdar Chen and Kevin J. Catt

  Molecular Pharmacology November 2008, 74 (5) 1223-1233; DOI: https://doi.org/10.1124/mol.108.048504
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  Reactive Oxygen Species Mediate p53 Activation and Apoptosis Induced by Sodium Nitroprusside in SH-SY5Y Cells

  Simone Cardaci, Giuseppe Filomeni, Giuseppe Rotilio and Maria R. Ciriolo

  Molecular Pharmacology November 2008, 74 (5) 1234-1245; DOI: https://doi.org/10.1124/mol.108.048975
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  Role of Key Transmembrane Residues in Agonist and Antagonist Actions at the Two Conformations of the Human β1-Adrenoceptor

  Jillian G. Baker, Richard G. W. Proudman, Nicola C. Hawley, Peter M. Fischer and Stephen J. Hill

  Molecular Pharmacology November 2008, 74 (5) 1246-1260; DOI: https://doi.org/10.1124/mol.108.048371
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  General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1

  Paul M. Cornett, José A. Matta and Gerard P. Ahern

  Molecular Pharmacology November 2008, 74 (5) 1261-1268; DOI: https://doi.org/10.1124/mol.108.049684
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  Ligand-Mediated Regulation of Peroxisome Proliferator-Activated Receptor (PPAR) β/δ: A Comparative Analysis of PPAR-Selective Agonists and All-trans Retinoic Acid

  Markus Rieck, Wolfgang Meissner, Simone Ries, Sabine Müller-Brüsselbach and Rolf Müller

  Molecular Pharmacology November 2008, 74 (5) 1269-1277; DOI: https://doi.org/10.1124/mol.108.050625
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  Morphine Desensitization, Internalization, and Down-Regulation of the μ Opioid Receptor Is Facilitated by Serotonin 5-Hydroxytryptamine_2A Receptor Coactivation

  Juan F. Lopez-Gimenez, M. Teresa Vilaró and Graeme Milligan

  Molecular Pharmacology November 2008, 74 (5) 1278-1291; DOI: https://doi.org/10.1124/mol.108.048272
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  Mitochondria-Dependent Reactive Oxygen Species-Mediated Programmed Cell Death Induced by 3,3′-Diindolylmethane through Inhibition of F0F1-ATP Synthase in Unicellular Protozoan Parasite Leishmania donovani

  Amit Roy, Agneyo Ganguly, Somdeb BoseDasgupta, Benu Brata Das, Churala Pal, Parasuraman Jaisankar and Hemanta K. Majumder

  Molecular Pharmacology November 2008, 74 (5) 1292-1307; DOI: https://doi.org/10.1124/mol.108.050161
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  Full Pharmacological Efficacy of a Novel S1P₁ Agonist That Does Not Require S1P-Like Headgroup Interactions

  Pedro J. Gonzalez-Cabrera, Euijung Jo, M. Germana Sanna, Steven Brown, Nora Leaf, David Marsolais, Marie-Therese Schaeffer, Jacqueline Chapman, Michael Cameron, Miguel Guerrero, Edward Roberts and Hugh Rosen

  Molecular Pharmacology November 2008, 74 (5) 1308-1318; DOI: https://doi.org/10.1124/mol.108.049783
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  Mitochondrial Respiratory Enzyme Complexes in Rostral Ventrolateral Medulla as Cellular Targets of Nitric Oxide and Superoxide Interaction in the Antagonism of Antihypertensive Action of eNOS Transgene

  Ling-Chang Kung, Samuel H. H. Chan, Kay L. H. Wu, Chen-Chun Ou, Ming-Hon Tai and Julie Y. H. Chan

  Molecular Pharmacology November 2008, 74 (5) 1319-1332; DOI: https://doi.org/10.1124/mol.108.048793
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  Coassembly of Different Sulfonylurea Receptor Subtypes Extends the Phenotypic Diversity of ATP-sensitive Potassium (K_ATP) Channels

  Adam Wheeler, Chuan Wang, Ke Yang, Kun Fang, Kevin Davis, Amanda M. Styer, Uyenlinh Mirshahi, Christophe Moreau, Jean Revilloud, Michel Vivaudou, Shunhe Liu, Tooraj Mirshahi and Kim W. Chan

  Molecular Pharmacology November 2008, 74 (5) 1333-1344; DOI: https://doi.org/10.1124/mol.108.048355
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  Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

  Colleen M. Niswender, Kari A. Johnson, C. David Weaver, Carrie K. Jones, Zixiu Xiang, Qingwei Luo, Alice L. Rodriguez, Joy E. Marlo, Tomas de Paulis, Analisa D. Thompson, Emily L. Days, Tasha Nalywajko, Cheryl A. Austin, Michael Baxter Williams, Jennifer E. Ayala, Richard Williams, Craig W. Lindsley and P. Jeffrey Conn

  Molecular Pharmacology November 2008, 74 (5) 1345-1358; DOI: https://doi.org/10.1124/mol.108.049551
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  Interleukin-8 Expression Is Regulated by Histone Deacetylases through the Nuclear Factor-κB Pathway in Breast Cancer

  Carine Chavey, Marcus Mühlbauer, Carine Bossard, Ariane Freund, Sébastien Durand, Christian Jorgensen, Christian Jobin and Gwendal Lazennec

  Molecular Pharmacology November 2008, 74 (5) 1359-1366; DOI: https://doi.org/10.1124/mol.108.047332
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  A Hypomorphic Allele of Aryl Hydrocarbon Receptor-Associated Protein-9 Produces a Phenocopy of the Ahr-Null Mouse

  Bernice C. Lin, Linh P. Nguyen, Jacqueline A. Walisser and Christopher A. Bradfield

  Molecular Pharmacology November 2008, 74 (5) 1367-1371; DOI: https://doi.org/10.1124/mol.108.047068
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  The Role of Human Nucleoside Transporters in Uptake of 3′-Deoxy-3′-fluorothymidine

  Robert J. Paproski, Amy M. L. Ng, Sylvia Y. M. Yao, Kathryn Graham, James D. Young and Carol E. Cass

  Molecular Pharmacology November 2008, 74 (5) 1372-1380; DOI: https://doi.org/10.1124/mol.108.048900
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  Anti-Inflammatory, Antiproliferative, and Cytoprotective Activity of NO Chimera Nitrates of Use in Cancer Chemoprevention

  Ghenet K. Hagos, Samer O. Abdul-Hay, Johann Sohn, Praneeth D. Edirisinghe, R. Esala P. Chandrasena, Zhiqiang Wang, Qian Li and Gregory R. J. Thatcher

  Molecular Pharmacology November 2008, 74 (5) 1381-1391; DOI: https://doi.org/10.1124/mol.108.046664
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  Muscarinic Modulation of Synaptic Transmission via Endocannabinoid Signalling in the Rat Midbrain Periaqueductal Gray

  Benjamin K. Lau and Christopher W. Vaughan

  Molecular Pharmacology November 2008, 74 (5) 1392-1398; DOI: https://doi.org/10.1124/mol.108.045872
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  Nonsteroidal Anti-Inflammatory Drugs Induced Endothelial Apoptosis by Perturbing Peroxisome Proliferator-Activated Receptor-δ Transcriptional Pathway

  Jun-Yang Liou, Chia-Ching Wu, Bo-Rui Chen, Linju B. Yen and Kenneth K. Wu

  Molecular Pharmacology November 2008, 74 (5) 1399-1406; DOI: https://doi.org/10.1124/mol.108.049569
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  Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment

  Daniel Bertrand, Sonia Bertrand, Steven Cassar, Earl Gubbins, Jinhe Li and M. Gopalakrishnan

  Molecular Pharmacology November 2008, 74 (5) 1407-1416; DOI: https://doi.org/10.1124/mol.107.042820
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  The β₃-Adrenoceptor Agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and Antagonist (S)-N-[4-[2-[[3-[3-(Acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) Activate Different Signaling Pathways in Chinese Hamster Ovary-K1 Cells Stably Expressing the Human β₃-Adrenoceptor

  Masaaki Sato, Dana S. Hutchinson, Bronwyn A. Evans and Roger J. Summers

  Molecular Pharmacology November 2008, 74 (5) 1417-1428; DOI: https://doi.org/10.1124/mol.108.046979
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  Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/δ Inhibits Cell Proliferation in Human HaCaT Keratinocytes

  Michael G. Borland, Jennifer E. Foreman, Elizabeth E. Girroir, Reza Zolfaghari, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, A. Catharine Ross and Jeffrey M. Peters

  Molecular Pharmacology November 2008, 74 (5) 1429-1442; DOI: https://doi.org/10.1124/mol.108.050609
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  Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-à-go-go-Related Gene Channels

  Mark J. Perrin, Philip W. Kuchel, Terence J. Campbell and Jamie I. Vandenberg

  Molecular Pharmacology November 2008, 74 (5) 1443-1452; DOI: https://doi.org/10.1124/mol.108.049056
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  Phosphodiesterase 4 and Phosphatase 2A Differentially Regulate cAMP/Protein Kinase A Signaling for Cardiac Myocyte Contraction under Stimulation of β₁ Adrenergic Receptor

  Vania De Arcangelis, Dagoberto Soto and Yang Xiang

  Molecular Pharmacology November 2008, 74 (5) 1453-1462; DOI: https://doi.org/10.1124/mol.108.049718
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  Cross-Talk between Dopaminergic and Noradrenergic Systems in the Rat Ventral Tegmental Area, Locus Ceruleus, and Dorsal Hippocampus

  Bruno P. Guiard, Mostafa El Mansari and Pierre Blier

  Molecular Pharmacology November 2008, 74 (5) 1463-1475; DOI: https://doi.org/10.1124/mol.108.048033
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  ProTx-II, a Selective Inhibitor of Na_V1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

  William A. Schmalhofer, Jeffrey Calhoun, Rachel Burrows, Timothy Bailey, Martin G. Kohler, Adam B. Weinglass, Gregory J. Kaczorowski, Maria L. Garcia, Martin Koltzenburg and Birgit T. Priest

  Molecular Pharmacology November 2008, 74 (5) 1476-1484; DOI: https://doi.org/10.1124/mol.108.047670