Abstract
Guanosine triphosphate (GTP) and dighosphate nucleotides decrease the binding of the agonist ligands [3H]apomorphine and [3H]ADTN to dopamine receptors in the rat corpus striatum with half maximal reduction of binding at 5 µM. These nucleotides also reduce agonist inhibition of the antagonist [3H]spiroperidol binding to dopamine receptors without affecting total [3H]spiroperidol binding. Guanosine monophosphate and adenine nucleotides display negligible influence on dopamine receptor binding. GTP reduces the affinity of [3H]apomorphine binding with no effect on the maximal numbers of binding sites.
ACKNOWLEDGMENTS We thank Mr. F. Douglas Reynolds for his help in initiating this study and Ms. Kim Stewart and Mr. Tim Prosser for their fine technical assistance.
- Copyright © 1979 by Academic Press, Inc.
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