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Research ArticleArticle

The Effect of Reduced and Oxidized Pteridine on Dopamine-β-Hydroxylase Activity

MENEK GOLDSTEIN and TONG HYUB JOH
Molecular Pharmacology July 1967, 3 (4) 396-398;

Abstract

Tetrahydropteridine (DMPH4) reacts with dopamine-β-hydroxylase anaerobically and forms a reduced enzyme intermediate which aerobically catalyzes the β-hydroxylation of tyramine-3H. Under aerobic conditions DMPH4, in combination with NADH, is effective in the stimulation of enzymic β-hydroxylation. Oxidized DMPH4 inhibits the enzymic activity.

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Research ArticleArticle

The Effect of Reduced and Oxidized Pteridine on Dopamine-β-Hydroxylase Activity

MENEK GOLDSTEIN and TONG HYUB JOH
Molecular Pharmacology July 1, 1967, 3 (4) 396-398;
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