Cover Caption
About the cover: Stereo view of the proposed interaction between the neuropeptide Y Y1 receptor and a nonpeptide analog of the carboxyl-terminal four amino acids of neuropeptide Y. The helices of the human Y1 receptor are shown in yellow ribbon, and the side chains of the binding site are shown in yellow. The nonpeptide analog BIB 3226 is colored by atom type (green, carbon; red, oxygen; blue, nitrogen; white, hydrogen). The model was derived by comparison of the affinity of neuropeptide Y and BIB 3226 to a large number of Y1 receptor mutants expressed in HeLa cells. From Sautel, M., K. Rudolph, H. Wittneben, H. Herzog, R. Martinez, M. Munoz, W. Eberlein, W. Engel, P. Walker, A. G. Beck-Sickinger. Neuropeptide Y and the nonpeptide antagonist BIBP 3226 share an overlapping binding siteatthe human Y1 receptor. Mol. Pharmacol. 50:285-292 (1996).
