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Research ArticleArticle

Single Mutations at Asn295 and Leu305 in the Cytoplasmic Half of Transmembrane α-Helix Domain 7 of the AT1 Receptor Induce Promiscuous Agonist Specificity for Angiotensin II Fragments: A Pseudo-Constitutive Activity

Ying-Hong Feng, Lingyin Zhou, Rongde Qiu and Robin Zeng
Molecular Pharmacology August 2005, 68 (2) 347-355; DOI: https://doi.org/10.1124/mol.105.011601

Article Information

vol. 68 no. 2 347-355
DOI 
https://doi.org/10.1124/mol.105.011601
PubMed 
15901848
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 1, 2005
  • Accepted May 17, 2005
  • Published online July 15, 2005.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ying-Hong Feng,
  2. Lingyin Zhou,
  3. Rongde Qiu and
  4. Robin Zeng
  1. Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland (Y.-H.F., R.Q.); and Department of Medicine, CWRU School of Medicine, Cleveland, Ohio (L.Z., R.Z.)
  1. Address correspondence to:
    Dr. Ying-Hong Feng, Department of Pharmacology, C2021, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814. E-mail: yhfeng{at}usuhs.mil
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Research ArticleArticle

Single Mutations at Asn295 and Leu305 in the Cytoplasmic Half of Transmembrane α-Helix Domain 7 of the AT1 Receptor Induce Promiscuous Agonist Specificity for Angiotensin II Fragments: A Pseudo-Constitutive Activity

Ying-Hong Feng, Lingyin Zhou, Rongde Qiu and Robin Zeng
Molecular Pharmacology August 1, 2005, 68 (2) 347-355; DOI: https://doi.org/10.1124/mol.105.011601
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