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Research ArticleArticle

Point Mutations in the Transmembrane Region of GABAB2 Facilitate Activation by the Positive Modulator N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the Absence of the GABAB1 Subunit

Delphine S. Dupuis, Dinko Relkovic, Loic Lhuillier, Johannes Mosbacher and Klemens Kaupmann
Molecular Pharmacology December 2006, 70 (6) 2027-2036; DOI: https://doi.org/10.1124/mol.106.028183

Article Information

vol. 70 no. 6 2027-2036
DOI 
https://doi.org/10.1124/mol.106.028183
PubMed 
16966477
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 22, 2006
  • Accepted September 11, 2006
  • Published online November 16, 2006.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Delphine S. Dupuis1,
  2. Dinko Relkovic2,
  3. Loic Lhuillier3,
  4. Johannes Mosbacher and
  5. Klemens Kaupmann
  1. Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
  1. Address correspondence to:
    Dr. Klemens Kaupmann, Novartis Institutes for BioMedical Research, Novartis Pharma AG, WKL-125.7.42, CH-4002 Basel, Switzerland. E-mail: klemens.kaupmann{at}novartis.com
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Research ArticleArticle

Point Mutations in the Transmembrane Region of GABAB2 Facilitate Activation by the Positive Modulator N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the Absence of the GABAB1 Subunit

Delphine S. Dupuis, Dinko Relkovic, Loic Lhuillier, Johannes Mosbacher and Klemens Kaupmann
Molecular Pharmacology December 1, 2006, 70 (6) 2027-2036; DOI: https://doi.org/10.1124/mol.106.028183
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