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Research ArticleArticle

Molecular Mechanisms Underlying the Synergistic Interaction of Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, with the Multitargeted Antifolate Pemetrexed in Non-Small-Cell Lung Cancer Cells

Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A. Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone and Godefridus J. Peters
Molecular Pharmacology April 2008, 73 (4) 1290-1300; DOI: https://doi.org/10.1124/mol.107.042382

Article Information

vol. 73 no. 4 1290-1300
DOI 
https://doi.org/10.1124/mol.107.042382
PubMed 
18187583
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 3, 2007
  • Accepted January 10, 2008
  • Published online March 17, 2008.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Elisa Giovannetti,
  2. Clara Lemos,
  3. Christina Tekle,
  4. Kees Smid,
  5. Sara Nannizzi,
  6. José A. Rodriguez,
  7. Simona Ricciardi,
  8. Romano Danesi,
  9. Giuseppe Giaccone and
  10. Godefridus J. Peters
  1. Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands (E.G., C.L., C.T., K.S., J.A.R., G.J.P.); Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy (E.G., S.N., S.R., R.D.); and Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland (G.G.)
  1. Address correspondence to:
    Dr. Elisa Giovannetti, Division of Pharmacology and Chemotherapy, Department of Internal Medicine, 55, Via Roma, 56126 Pisa, Italy. E-mail: elisa.giovannetti{at}gmail.com
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Research ArticleArticle

Molecular Mechanisms Underlying the Synergistic Interaction of Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, with the Multitargeted Antifolate Pemetrexed in Non-Small-Cell Lung Cancer Cells

Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A. Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone and Godefridus J. Peters
Molecular Pharmacology April 1, 2008, 73 (4) 1290-1300; DOI: https://doi.org/10.1124/mol.107.042382
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