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Research ArticleArticle

90-kDa Heat Shock Protein Inhibition Abrogates the Topoisomerase I Poison-Induced G2/M Checkpoint in p53-Null Tumor Cells by Depleting Chk1 and Wee1

Archie N. Tse, Tahir N. Sheikh, Ho Alan, Ting-Chao Chou and Gary K. Schwartz
Molecular Pharmacology January 2009, 75 (1) 124-133; DOI: https://doi.org/10.1124/mol.108.050807

Article Information

vol. 75 no. 1 124-133
DOI 
https://doi.org/10.1124/mol.108.050807
PubMed 
18820127
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 28, 2008
  • Accepted September 26, 2008
  • Published online December 19, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Archie N. Tse,
  2. Tahir N. Sheikh,
  3. Ho Alan,
  4. Ting-Chao Chou and
  5. Gary K. Schwartz
  1. Laboratory of New Drug Development, Division of Solid Tumor Oncology, Department of Medicine (A.N.T., T.N.S., H.A., G.K.S.), and Molecular Pharmacology and Chemistry Program (T.C.C.), Memorial Sloan Kettering Cancer Center, New York, New York
  1. Address correspondence to:
    Dr. Archie N. Tse, Memorial Sloan-Kettering Cancer Center, Department of Medicine, New York, NY 10021. E-mail: tsea{at}mskcc.org
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Research ArticleArticle

90-kDa Heat Shock Protein Inhibition Abrogates the Topoisomerase I Poison-Induced G2/M Checkpoint in p53-Null Tumor Cells by Depleting Chk1 and Wee1

Archie N. Tse, Tahir N. Sheikh, Ho Alan, Ting-Chao Chou and Gary K. Schwartz
Molecular Pharmacology January 1, 2009, 75 (1) 124-133; DOI: https://doi.org/10.1124/mol.108.050807
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