A research misconduct investigation at the University of Houston initiated by Dr. S. E. Dryer has found that figures in this article were inappropriately manipulated and falsified. Portions of the same actin blots were improperly used to represent results from different experiments in Figures 2A and 4A.
Molecular Pharmacology in agreement with Dr. Dryer has retracted this article.
- Copyright © 2016 The American Society for Pharmacology and Experimental Therapeutics
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- Notice of Retraction: Acharya P, Chen J-J, Correia MA (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2α kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. Mol Pharmacol 77(4):575–592; doi:10.1124/mol.109.061259.
- Notice of Retraction: Acharya P, Engel JC, Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2α (eIF2α)-kinase (PERK) and general control nonderepressible-2 eIF2α kinase (GCN2), and global translational shutoff. Mol Pharmacol 76(3):503–515; DOI: https://doi.org/10.1124/mol.109.056002.
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