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G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin

Jiansong Luo, John M. Busillo, Ralf Stumm and Jeffrey L. Benovic
Molecular Pharmacology June 2017, 91 (6) 554-566; DOI: https://doi.org/10.1124/mol.116.106468

Article Information

vol. 91 no. 6 554-566
DOI 
https://doi.org/10.1124/mol.116.106468
PubMed 
28331048
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 10, 2016
  • Accepted March 17, 2017
  • Published online May 2, 2017.

Article Versions

Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jiansong Luo,
  2. John M. Busillo1,
  3. Ralf Stumm, and
  4. Jeffrey L. Benovic
  1. Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (J.L., J.M.B., J.L.B.); and Institute of Pharmacology and Toxicology, University Hospital, Friedrich-Schiller University, Jena, Germany (R.S.)
  1. Address correspondence to:
    Dr. Jeffrey L. Benovic, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233 S. 10th Street, 926 BLSB, Philadelphia, PA 19107. E-mail: jeffrey.benovic{at}jefferson.edu
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Research ArticleArticle

GRK3/PKC Regulate CXCR4 Phosphorylation and Arrestin Binding

Jiansong Luo, John M. Busillo, Ralf Stumm and Jeffrey L. Benovic
Molecular Pharmacology June 1, 2017, 91 (6) 554-566; DOI: https://doi.org/10.1124/mol.116.106468
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