Abstract
The conversion of trichloroethylene to chloral hydrate was shown to take place in liver microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates in Tris buffer was used, from which a fraction could be obtained which resembled fresh microsomes in behavior. The effects of a number of activators and inhibitors of the enzyme system are described.
ACKNOWLEDGMENTS It is a pleasure to acknowledge the excellent technical assistance of Miss Elsa Ortiz. This work was supported in part by U.S. Public Health Service Research Grant No. OH-00124.
- Copyright ©, 1965, by Academic Press Inc.
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