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Spin Trapping of the Primary Radical Involved in the Activation of the Carcinogen N-Hydroxy-2-acetylaminofluorene by Cumene Hydroperoxide-Hematin

GERALD M. ROSEN and ELMER J. RAUCKMAN
Molecular Pharmacology March 1980, 17 (2) 233-238;

Abstract

We have verified that the cumene hydroperoxide-hematin system reacts with 5,5-dimethyl-1-pyrroline-1-oxide to form the nitroxide 5,5-dimethyl-pyrrolidone-(2)-oxyl-(1) (DMPOX). We have investigated the mechanism of this reaction and found that it is not a simple oxidation, as has been previously reported, but that DMPOX is formed via the spin trapping of a cumene hydroperoxyl radical followed by an intramolecular carbanion displacement. The activation of the carcinogen, N-hydroxyl-2-acetylaminofluorene, by the cumene hydroperoxide-hematin system is most likely mediated by cumene hydroperoxyl radical.

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Research ArticleArticle

Spin Trapping of the Primary Radical Involved in the Activation of the Carcinogen N-Hydroxy-2-acetylaminofluorene by Cumene Hydroperoxide-Hematin

GERALD M. ROSEN and ELMER J. RAUCKMAN
Molecular Pharmacology March 1, 1980, 17 (2) 233-238;
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