Abstract
Formycin B, an analog of inosine, is a potent competitive inhibitor of purified erythrocytic purine nucleoside phosphorylase. The inhibition constant, Ki (1 x 10-4 M) is of the same order of magnitude as the Km for inosine (5 x 10-5 M). Formycin B also inhibits the degradation of nucleosides by intact and hemolyzed human erythrocytes and by Sarcoma 180 ascites cells.
ACKNOWLEDGMENT The authors would like to express their appreciation to Dr. Sungnan Cha for his help in the preparation of this manuscript.
- Copyright ©, 1968, by Academic Press Inc.
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