Multiple Mechanisms of Resistance to Polyglutamatable and Lipophilic Antifolates in Mammalian Cells: Role of Increased Folylpolyglutamylation, Expanded Folate Pools, and Intralysosomal Drug Sequestration

Gerrit Jansen; Haim Barr; Ietje Kathmann; Marlene A. Bunni; David G. Priest; Paul Noordhuis; Godefridus J. Peters; Yehuda G. Assaraf

Research ArticleArticle

Multiple Mechanisms of Resistance to Polyglutamatable and Lipophilic Antifolates in Mammalian Cells: Role of Increased Folylpolyglutamylation, Expanded Folate Pools, and Intralysosomal Drug Sequestration

Gerrit Jansen, Haim Barr, Ietje Kathmann, Marlene A. Bunni, David G. Priest, Paul Noordhuis, Godefridus J. Peters and Yehuda G. Assaraf

Molecular Pharmacology April 1999, 55 (4) 761-769;

Gerrit Jansen

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Haim Barr

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Ietje Kathmann

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Marlene A. Bunni

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David G. Priest

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Paul Noordhuis

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Godefridus J. Peters

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Yehuda G. Assaraf

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Molecular Pharmacology

Vol. 55, Issue 4

1 Apr 1999

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Research ArticleArticle

Multiple Mechanisms of Resistance to Polyglutamatable and Lipophilic Antifolates in Mammalian Cells: Role of Increased Folylpolyglutamylation, Expanded Folate Pools, and Intralysosomal Drug Sequestration

Gerrit Jansen, Haim Barr, Ietje Kathmann, Marlene A. Bunni, David G. Priest, Paul Noordhuis, Godefridus J. Peters and Yehuda G. Assaraf

Molecular Pharmacology April 1, 1999, 55 (4) 761-769;

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Research ArticleArticle

Multiple Mechanisms of Resistance to Polyglutamatable and Lipophilic Antifolates in Mammalian Cells: Role of Increased Folylpolyglutamylation, Expanded Folate Pools, and Intralysosomal Drug Sequestration

Gerrit Jansen, Haim Barr, Ietje Kathmann, Marlene A. Bunni, David G. Priest, Paul Noordhuis, Godefridus J. Peters and Yehuda G. Assaraf

Molecular Pharmacology April 1, 1999, 55 (4) 761-769;

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Multiple Mechanisms of Resistance to Polyglutamatable and Lipophilic Antifolates in Mammalian Cells: Role of Increased Folylpolyglutamylation, Expanded Folate Pools, and Intralysosomal Drug Sequestration

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