Point Mutations at L1280 in Nav1.4 Channel D3-S6 Modulate  Binding Affinity and Stereoselectivity of Bupivacaine Enantiomers

Carla Nau; Sho-Ya Wang; Ging Kuo Wang

doi:10.1124/mol.63.6.1398

Research ArticleArticle

Point Mutations at L1280 in Na_v1.4 Channel D3-S6 Modulate Binding Affinity and Stereoselectivity of Bupivacaine Enantiomers

Carla Nau, Sho-Ya Wang and Ging Kuo Wang

Molecular Pharmacology June 2003, 63 (6) 1398-1406; DOI: https://doi.org/10.1124/mol.63.6.1398

Carla Nau

Department of Anesthesiology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany (C.N.); Department of Biological Sciences, State University of New York at Albany, Albany, New York (S.-Y.W.); and Department of Anesthesia Research Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (G.K.W.)

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Sho-Ya Wang

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Ging Kuo Wang

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Molecular Pharmacology

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1 Jun 2003

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Research ArticleArticle

Point Mutations at L1280 in Na_v1.4 Channel D3-S6 Modulate Binding Affinity and Stereoselectivity of Bupivacaine Enantiomers

Carla Nau, Sho-Ya Wang and Ging Kuo Wang

Molecular Pharmacology June 1, 2003, 63 (6) 1398-1406; DOI: https://doi.org/10.1124/mol.63.6.1398

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Research ArticleArticle

Point Mutations at L1280 in Na_v1.4 Channel D3-S6 Modulate Binding Affinity and Stereoselectivity of Bupivacaine Enantiomers

Carla Nau, Sho-Ya Wang and Ging Kuo Wang

Molecular Pharmacology June 1, 2003, 63 (6) 1398-1406; DOI: https://doi.org/10.1124/mol.63.6.1398

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