Table of Contents

Articles

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  Estrogen Increases Mitochondrial Efficiency and Reduces Oxidative Stress in Cerebral Blood Vessels

  Chris Stirone, Sue P. Duckles, Diana N. Krause and Vincent Procaccio

  Molecular Pharmacology October 2005, 68 (4) 959-965; DOI: https://doi.org/10.1124/mol.105.014662
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  Investigation of the Phenylalkylamine Binding Site in hKv1.3 (H399T), a Mutant with a Reduced C-Type Inactivated State

  Tobias Dreker and Stephan Grissmer

  Molecular Pharmacology October 2005, 68 (4) 966-973; DOI: https://doi.org/10.1124/mol.105.012401
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  Characterization of Novel Aryl-Ether, Biaryl, and Fluorene Aspartic Acid and Diaminopropionic Acid Analogs as Potent Inhibitors of the High-Affinity Glutamate Transporter EAAT2

  John Dunlop, H. Beal McIlvain, Tikva A. Carrick, Brian Jow, Qiang Lu, Dianne Kowal, Steven Lin, Alexander Greenfield, Cristina Grosanu, Kristi Fan, Robert Petroski, John Williams, Alan Foster and John Butera

  Molecular Pharmacology October 2005, 68 (4) 974-982; DOI: https://doi.org/10.1124/mol.105.012005
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  Reactive Oxygen Species Elicit Apoptosis by Concurrently Disrupting Topoisomerase II and DNA-Dependent Protein Kinase

  Hua-Rui Lu, Hong Zhu, Min Huang, Yi Chen, Yu-Jun Cai, Ze-Hong Miao, Jin-Sheng Zhang and Jian Ding

  Molecular Pharmacology October 2005, 68 (4) 983-994; DOI: https://doi.org/10.1124/mol.105.011544
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  Structural Basis for Competition between Drug Binding and Kvβ1.3 Accessory Subunit-Induced N-Type Inactivation of Kv1.5 Channels

  Niels Decher, Pradeep Kumar, Teresa Gonzalez, Vijay Renigunta and Michael C. Sanguinetti

  Molecular Pharmacology October 2005, 68 (4) 995-1005; DOI: https://doi.org/10.1124/mol.105.011668
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  Nitric Oxide Donors Induce Neurotrophin-Like Survival Signaling and Protect Neurons against Apoptosis

  Carsten Culmsee, Norbert Gerling, Stefan Landshamer, Bianca Rickerts, Hans-Jürgen Duchstein, Kazuo Umezawa, Susanne Klumpp and Josef Krieglstein

  Molecular Pharmacology October 2005, 68 (4) 1006-1017; DOI: https://doi.org/10.1124/mol.105.013086
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  Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids

  Won Jun Lee, Joong-Youn Shim and Bao Ting Zhu

  Molecular Pharmacology October 2005, 68 (4) 1018-1030; DOI: https://doi.org/10.1124/mol.104.008367
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  Human Hepatobiliary Transport of Organic Anions Analyzed by Quadruple-Transfected Cells

  Kathrin Kopplow, Katrin Letschert, Jörg König, Bettina Walter and Dietrich Keppler

  Molecular Pharmacology October 2005, 68 (4) 1031-1038; DOI: https://doi.org/10.1124/mol.105.014605
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  Differential Activation of Adenylate Cyclase and Receptor Internalization by Novel Dopamine D₁ Receptor Agonists

  Jessica P. Ryman-Rasmussen, David E. Nichols and Richard B. Mailman

  Molecular Pharmacology October 2005, 68 (4) 1039-1048; DOI: https://doi.org/10.1124/mol.105.012153
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  N-Methyl-N′-nitro-N-nitrosoguanidine Activates Cell-Cycle Arrest through Distinct Mechanisms Activated in a Dose-Dependent Manner

  Dillon I. Beardsley, Wan-Ju Kim and Kevin D. Brown

  Molecular Pharmacology October 2005, 68 (4) 1049-1060; DOI: https://doi.org/10.1124/mol.105.013888
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  Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt and p38 Mitogen-Activated Protein Kinase Pathways in Osteoblasts

  Men Luh Yen, Jen Liang Su, Chung Liang Chien, Kuang Wen Tseng, Ching Yao Yang, Wei Fang Chen, Chiao Chia Chang and Min Liang Kuo

  Molecular Pharmacology October 2005, 68 (4) 1061-1073; DOI: https://doi.org/10.1124/mol.104.010082
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  Overexpression of Rad23 Confers Resistance to Methylmercury in Saccharomyces cerevisiae via Inhibition of the Degradation of Ubiquitinated Proteins

  Gi-Wook Hwang, Daisuke Sasaki and Akira Naganuma

  Molecular Pharmacology October 2005, 68 (4) 1074-1078; DOI: https://doi.org/10.1124/mol.105.013516
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  Interaction of Bivalent Ligand KDN21 with Heterodimeric δ-κ Opioid Receptors in Human Embryonic Kidney 293 Cells

  Zhihua Xie, Rashmi G. Bhushan, David J. Daniels and Philip S. Portoghese

  Molecular Pharmacology October 2005, 68 (4) 1079-1086; DOI: https://doi.org/10.1124/mol.105.012070
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  Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway

  Heui-Young Ryu, Jessica K. Emberley, Jennifer J. Schlezinger, Lenka L. Allan, Songqing Na and David H. Sherr

  Molecular Pharmacology October 2005, 68 (4) 1087-1096; DOI: https://doi.org/10.1124/mol.105.014712
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  Mechanism of the Insulin-Releasing Action of α-Ketoisocaproate and Related α-Keto Acid Anions

  Henrike Heissig, Karin A. Urban, Katja Hastedt, Bernd J. Zünkler and Uwe Panten

  Molecular Pharmacology October 2005, 68 (4) 1097-1105; DOI: https://doi.org/10.1124/mol.105.015388
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  Sialylation of Human Thyrotropin Receptor Improves and Prolongs Its Cell-Surface Expression

  Romy Frenzel, Knut Krohn, Markus Eszlinger, Anke Tönjes and Ralf Paschke

  Molecular Pharmacology October 2005, 68 (4) 1106-1113; DOI: https://doi.org/10.1124/mol.105.012906
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  Characteristics of Ginsenoside Rg₃-Mediated Brain Na⁺ Current Inhibition

  Jun-Ho Lee, Sang Min Jeong, Jong-Hoon Kim, Byung-Hwan Lee, In-Soo Yoon, Joon-Hee Lee, Sun-Hye Choi, Dong-Hyun Kim, Hyewhon Rhim, Sung Soo Kim, Jai-Il Kim, Choon-Gon Jang, Jin-Ho Song and Seung-Yeol Nah

  Molecular Pharmacology October 2005, 68 (4) 1114-1126; DOI: https://doi.org/10.1124/mol.105.015115
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  Morphine-Induced μ-Opioid Receptor Desensitization

  Vu C. Dang and John T. Williams

  Molecular Pharmacology October 2005, 68 (4) 1127-1132; DOI: https://doi.org/10.1124/mol.105.013185
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  Interaction between the 90-kDa Heat Shock Protein and Soluble Guanylyl Cyclase: Physiological Significance and Mapping of the Domains Mediating Binding

  Andreas Papapetropoulos, Zongmin Zhou, Christina Gerassimou, Gunay Yetik, Richard C. Venema, Charis Roussos, William C. Sessa and John D. Catravas

  Molecular Pharmacology October 2005, 68 (4) 1133-1141; DOI: https://doi.org/10.1124/mol.105.012682
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  Icilin Activates the δ-Subunit of the Human Epithelial Na⁺ Channel

  Hisao Yamamura, Shinya Ugawa, Takashi Ueda, Masataka Nagao and Shoichi Shimada

  Molecular Pharmacology October 2005, 68 (4) 1142-1147; DOI: https://doi.org/10.1124/mol.104.010850
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  Principles of N-Methyl-d-aspartate Receptor Allosteric Modulation

  Gabriela Popescu

  Molecular Pharmacology October 2005, 68 (4) 1148-1155; DOI: https://doi.org/10.1124/mol.105.013896
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  Geranylgeranylacetone Protects Membranes against Nonsteroidal Anti-Inflammatory Drugs

  Hironori Ushijima, Ken-Ichiiro Tanaka, Miho Takeda, Takashi Katsu, Shinji Mima and Tohru Mizushima

  Molecular Pharmacology October 2005, 68 (4) 1156-1161; DOI: https://doi.org/10.1124/mol.105.015784
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  Heterogeneity and Selective Targeting of Neuronal Nicotinic Acetylcholine Receptor (nAChR) Subtypes Expressed on Retinal Afferents of the Superior Colliculus and Lateral Geniculate Nucleus: Identification of a New Native nAChR Subtype α3β2(α5 or β3) Enriched in Retinocollicular Afferents

  Cecilia Gotti, Milena Moretti, Alessio Zanardi, Annalisa Gaimarri, Nicolas Champtiaux, Jean-Pierre Changeux, Paul Whiteaker, Michael J. Marks, Francesco Clementi and Michele Zoli

  Molecular Pharmacology October 2005, 68 (4) 1162-1171; DOI: https://doi.org/10.1124/mol.105.015925
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  Charged Residues of the Conserved DRY Triplet of the Vasopressin V1a Receptor Provide Molecular Determinants for Cell Surface Delivery and Internalization

  Stuart R. Hawtin

  Molecular Pharmacology October 2005, 68 (4) 1172-1182; DOI: https://doi.org/10.1124/mol.105.013359
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  Nitric Oxide Inhibits Endothelin-1-Induced Cardiomyocyte Hypertrophy through cGMP-mediated Suppression of Extracellular-Signal Regulated Kinase Phosphorylation

  Tzu-Hurng Cheng, Neng-Lang Shih, Shin-Yee Chen, Jia-Wei Lin, Yen-Ling Chen, Cheng-Hsien Chen, Heng Lin, Ching-Feng Cheng, Wen-Ta Chiu, Danny Ling Wang and Jin-Jer Chen

  Molecular Pharmacology October 2005, 68 (4) 1183-1192; DOI: https://doi.org/10.1124/mol.105.014449