Table of Contents

Articles

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  Stimulation of Endocannabinoid Formation in Brain Slice Cultures through Activation of Group I Metabotropic Glutamate Receptors

  Kwang-Mook Jung, Regina Mangieri, Christopher Stapleton, Janet Kim, Darren Fegley, Matthew Wallace, Ken Mackie and Daniele Piomelli

  Molecular Pharmacology November 2005, 68 (5) 1196-1202; DOI: https://doi.org/10.1124/mol.105.013961
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  15-Deoxy-Δ^12,14 Prostaglandin J₂ Up-Regulates Krüppel-Like Factor 4 Expression Independently of Peroxisome Proliferator-Activated Receptor γ by Activating the Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signal Transduction Pathway in HT-29 Colon Cancer Cells

  Zhi Yi Chen and Chi-Chuan Tseng

  Molecular Pharmacology November 2005, 68 (5) 1203-1213; DOI: https://doi.org/10.1124/mol.105.014944
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  Substance P, Neurokinins A and B, and Synthetic Tachykinin Peptides Protect Mesencephalic Dopaminergic Neurons in Culture via an Activity-Dependent Mechanism

  Bénédicte Salthun-Lassalle, Sabine Traver, Etienne C. Hirsch and Patrick P. Michel

  Molecular Pharmacology November 2005, 68 (5) 1214-1224; DOI: https://doi.org/10.1124/mol.105.015453
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  Expression Profiling of Rat Femur Revealed Suppression of Bone Formation Genes by Treatment with Alendronate and Estrogen but Not Raloxifene

  Leah M. Helvering, Riting Liu, Nalini H. Kulkarni, Tao Wei, Peining Chen, Shuguang Huang, Frank Lawrence, David L. Halladay, Rebecca R. Miles, Emily M. Ambrose, Masahiko Sato, Yanfei L. Ma, Charles A. Frolik, Ernst R. Dow, Henry U. Bryant and Jude E. Onyia

  Molecular Pharmacology November 2005, 68 (5) 1225-1238; DOI: https://doi.org/10.1124/mol.105.011478
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  Retinoid X Receptor-α-Dependent Transactivation by a Naturally Occurring Structural Variant of Human Constitutive Androstane Receptor (NR1I3)

  Scott S. Auerbach, Matthew A. Stoner, Shengzhong Su and Curtis J. Omiecinski

  Molecular Pharmacology November 2005, 68 (5) 1239-1253; DOI: https://doi.org/10.1124/mol.105.013417
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  Design of PAP-1, a Selective Small Molecule Kv1.3 Blocker, for the Suppression of Effector Memory T Cells in Autoimmune Diseases

  Alexander Schmitz, Ananthakrishnan Sankaranarayanan, Philippe Azam, Kristina Schmidt-Lassen, Daniel Homerick, Wolfram Hänsel and Heike Wulff

  Molecular Pharmacology November 2005, 68 (5) 1254-1270; DOI: https://doi.org/10.1124/mol.105.015669
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  Characterization of Determinants of Ligand Binding to the Nicotinic Acid Receptor GPR109A (HM74A/PUMA-G)

  Sorin Tunaru, Jens Lättig, Jukka Kero, Gerd Krause and Stefan Offermanns

  Molecular Pharmacology November 2005, 68 (5) 1271-1280; DOI: https://doi.org/10.1124/mol.105.015750
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  A Prodrug of Cysteine, l-2-Oxothiazolidine-4-carboxylic Acid, Regulates Vascular Permeability by Reducing Vascular Endothelial Growth Factor Expression in Asthma

  Kyung Sun Lee, Hee Sun Park, Seoung Ju Park, So Ri Kim, Kyung Hoon Min, Sun Mi Jin, Kwang-Hyun Park, Uh-Hyun Kim, Chan Young Kim and Yong Chul Lee

  Molecular Pharmacology November 2005, 68 (5) 1281-1290; DOI: https://doi.org/10.1124/mol.105.016055
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  Comparative Models of GABA_A Receptor Extracellular and Transmembrane Domains: Important Insights in Pharmacology and Function

  Margot Ernst, Stefan Bruckner, Stefan Boresch and Werner Sieghart

  Molecular Pharmacology November 2005, 68 (5) 1291-1300; DOI: https://doi.org/10.1124/mol.105.015982
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  Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide Receptor Antagonists

  Bruce S. Edwards, Cristian Bologa, Susan M. Young, Konstantin V. Balakin, Eric R. Prossnitz, Nikolay P. Savchuck, Larry A. Sklar and Tudor I. Oprea

  Molecular Pharmacology November 2005, 68 (5) 1301-1310; DOI: https://doi.org/10.1124/mol.105.014068
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  RNA Interference against Human Papillomavirus Oncogenes in Cervical Cancer Cells Results in Increased Sensitivity to Cisplatin

  Lisa N. Putral, Megan J. Bywater, Wenyi Gu, Nicholas A. Saunders, Brian G. Gabrielli, Graham R. Leggatt and Nigel A. J. McMillan

  Molecular Pharmacology November 2005, 68 (5) 1311-1319; DOI: https://doi.org/10.1124/mol.105.014191
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  Src Family Kinase Activity Is Required for Murine Embryonic Stem Cell Growth and Differentiation

  Malcolm A. Meyn, Steven J. Schreiner, Teodora Pene Dumitrescu, Gerard J. Nau and Thomas E. Smithgall

  Molecular Pharmacology November 2005, 68 (5) 1320-1330; DOI: https://doi.org/10.1124/mol.104.010231
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  Roscovitine Triggers Excitotoxicity in Cultured Granule Neurons by Enhancing Glutamate Release

  Edward A. Monaco and Mary Lou Vallano

  Molecular Pharmacology November 2005, 68 (5) 1331-1342; DOI: https://doi.org/10.1124/mol.105.012732
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  Cigarette Smoke Activates Human Monocytes by an Oxidant-AP-1 Signaling Pathway: Implications for Steroid Resistance

  Matthew J. Walters, Mark J. Paul-Clark, Shaun K. McMaster, Kazuhiro Ito, Ian M. Adcock and Jane A. Mitchell

  Molecular Pharmacology November 2005, 68 (5) 1343-1353; DOI: https://doi.org/10.1124/mol.105.012591
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  G_q-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the G_s-Coupled Dopamine D₁ Receptor in COS-7 Cells

  Anthony S. L. Chan and Yung H. Wong

  Molecular Pharmacology November 2005, 68 (5) 1354-1364; DOI: https://doi.org/10.1124/mol.105.014548
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  Large-Scale Analysis of Genes that Alter Sensitivity to the Anticancer Drug Tirapazamine in Saccharomyces cerevisiae

  Karen Hellauer, Guillaume Lesage, Anne-Marie Sdicu and Bernard Turcotte

  Molecular Pharmacology November 2005, 68 (5) 1365-1375; DOI: https://doi.org/10.1124/mol.105.012963
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  Mice Lacking the α4 Nicotinic Receptor Subunit Fail to Modulate Dopaminergic Neuronal Arbors and Possess Impaired Dopamine Transporter Function

  C. L. Parish, J. Nunan, D. I. Finkelstein, F. N. McNamara, J. Y. Wong, J. L. Waddington, R. M. Brown, A. J. Lawrence, M. K. Horne and J. Drago

  Molecular Pharmacology November 2005, 68 (5) 1376-1386; DOI: https://doi.org/10.1124/mol.104.004820
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  Presynaptic Inhibition via a Phospholipase C- and Phosphatidylinositol Bisphosphate-Dependent Regulation of Neuronal Ca²⁺ Channels

  Stefan G. Lechner, Simon Hussl, Klaus W. Schicker, Helmut Drobny and Stefan Boehm

  Molecular Pharmacology November 2005, 68 (5) 1387-1396; DOI: https://doi.org/10.1124/mol.105.014886
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  Interaction of Organic Cations with a Newly Identified Plasma Membrane Monoamine Transporter

  Karen Engel and Joanne Wang

  Molecular Pharmacology November 2005, 68 (5) 1397-1407; DOI: https://doi.org/10.1124/mol.105.016832
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  Role of the Redox Protein Thioredoxin in Cytoprotective Mechanism Evoked by (-)-Deprenyl

  Tsugunobu Andoh, P. Boon Chock, Dennis L. Murphy and Chuang C. Chiueh

  Molecular Pharmacology November 2005, 68 (5) 1408-1414; DOI: https://doi.org/10.1124/mol.105.012302
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  Alkylation of β-Tubulin on Glu 198 by a Microtubule Disrupter

  Bernadette Bouchon, Christophe Chambon, Emmanuelle Mounetou, Janine Papon, Elisabeth Miot-Noirault, René C. Gaudreault, Jean-Claude Madelmont and Françoise Degoul

  Molecular Pharmacology November 2005, 68 (5) 1415-1422; DOI: https://doi.org/10.1124/mol.105.015586
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  Scavenger Receptors on Sinusoidal Liver Endothelial Cells Are Involved in the Uptake of Aldehyde-Modified Proteins

  Michael J. Duryee, Thomas L. Freeman, Monte S. Willis, Carlos D. Hunter, Bartlett C. Hamilton, Hiroshi Suzuki, Dean J. Tuma, Lynell W. Klassen and Geoffrey M. Thiele

  Molecular Pharmacology November 2005, 68 (5) 1423-1430; DOI: https://doi.org/10.1124/mol.105.016121
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  RIC-3 Enhances Functional Expression of Multiple Nicotinic Acetylcholine Receptor Subtypes in Mammalian Cells

  Stuart J. Lansdell, Veronica J. Gee, Patricia C. Harkness, Anne I. Doward, Elizabeth R. Baker, Alasdair J. Gibb and Neil S. Millar

  Molecular Pharmacology November 2005, 68 (5) 1431-1438; DOI: https://doi.org/10.1124/mol.105.017459
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  Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanism

  Susanne Kubetzko, Casim A. Sarkar and Andreas Plückthun

  Molecular Pharmacology November 2005, 68 (5) 1439-1454; DOI: https://doi.org/10.1124/mol.105.014910
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  Analysis of Human Multidrug Resistance Protein 1 (ABCC1) by Matrix-Assisted Laser Desorption Ionization/Time of Flight Mass Spectrometry: Toward Identification of Leukotriene C₄ Binding Sites

  Peng Wu, Curtis J. Oleschuk, Qingcheng Mao, Bernd O. Keller, Roger G. Deeley and Susan P. C. Cole

  Molecular Pharmacology November 2005, 68 (5) 1455-1465; DOI: https://doi.org/10.1124/mol.105.016576
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  Mastoparan Changes the Cellular Localization of Gα_q/11 and Gβ through Its Binding to Ganglioside in Lipid Rafts

  Jun Sugama, Satoko Ohkubo, Masanori Atsumi and Norimichi Nakahata

  Molecular Pharmacology November 2005, 68 (5) 1466-1474; DOI: https://doi.org/10.1124/mol.105.013524
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  Single-Channel Kinetic Analysis of Chimeric α7–5HT_3A Receptors

  Diego Rayes, Guillermo Spitzmaul, Steven M. Sine and Cecilia Bouzat

  Molecular Pharmacology November 2005, 68 (5) 1475-1483; DOI: https://doi.org/10.1124/mol.105.015438
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  Allosteric Modulation of the Cannabinoid CB₁ Receptor

  Martin R. Price, Gemma L. Baillie, Adèle Thomas, Lesley A. Stevenson, Morag Easson, Richard Goodwin, Adèle McLean, Lorraine McIntosh, Gillian Goodwin, Glenn Walker, Paul Westwood, Julia Marrs, Fiona Thomson, Phillip Cowley, Arthur Christopoulos, Roger G. Pertwee and Ruth A. Ross

  Molecular Pharmacology November 2005, 68 (5) 1484-1495; DOI: https://doi.org/10.1124/mol.105.016162
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  Selective Effects of the Anticancer Drug Yondelis (ET-743) on Cell-Cycle Promoters

  Mario Minuzzo, Michele Ceribelli, Marià Pitarque-Martì, Serena Borrelli, Eugenio Erba, Alberto diSilvio, Maurizio D'Incalci and Roberto Mantovani

  Molecular Pharmacology November 2005, 68 (5) 1496-1503; DOI: https://doi.org/10.1124/mol.105.013615