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Research ArticleArticle

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

Cassandra Koole, Denise Wootten, John Simms, Celine Valant, Rohan Sridhar, Owen L. Woodman, Laurence J. Miller, Roger J. Summers, Arthur Christopoulos and Patrick M. Sexton
Molecular Pharmacology September 2010, 78 (3) 456-465; DOI: https://doi.org/10.1124/mol.110.065664

Article Information

vol. 78 no. 3 456-465
DOI 
https://doi.org/10.1124/mol.110.065664
PubMed 
20547734
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 16, 2010
  • Accepted June 14, 2010
  • Published online August 18, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cassandra Koole,
  2. Denise Wootten,
  3. John Simms,
  4. Celine Valant,
  5. Rohan Sridhar,
  6. Owen L. Woodman,
  7. Laurence J. Miller,
  8. Roger J. Summers,
  9. Arthur Christopoulos and
  10. Patrick M. Sexton
  1. Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (C.K., D.W., C.V., A.C., R.J.S., R.S., J.S., P.M.S.); Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.); and School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia (O.L.W.).
  1. Address correspondence to:
    Prof. Patrick M. Sexton, Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. E-mail: patrick.sexton{at}med.monash.edu.au

  1. C.K., D.W. and J.S. contributed equally to this work.

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Research ArticleArticle

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

Cassandra Koole, Denise Wootten, John Simms, Celine Valant, Rohan Sridhar, Owen L. Woodman, Laurence J. Miller, Roger J. Summers, Arthur Christopoulos and Patrick M. Sexton
Molecular Pharmacology September 1, 2010, 78 (3) 456-465; DOI: https://doi.org/10.1124/mol.110.065664
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