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Research ArticleArticle

Identification and Mechanism of Action of the Acylguanidine MRT-83, a Novel Potent Smoothened Antagonist

Hermine Roudaut, Elisabeth Traiffort, Tatiana Gorojankina, Ludwig Vincent, Helene Faure, Angele Schoenfelder, Andre Mann, Fabrizio Manetti, Antonio Solinas, Maurizio Taddei and Martial Ruat
Molecular Pharmacology March 2011, 79 (3) 453-460; DOI: https://doi.org/10.1124/mol.110.069708

Article Information

vol. 79 no. 3 453-460
DOI 
https://doi.org/10.1124/mol.110.069708
PubMed 
21177415
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 29, 2010
  • Accepted December 21, 2010
  • Published online February 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hermine Roudaut,
  2. Elisabeth Traiffort,
  3. Tatiana Gorojankina,
  4. Ludwig Vincent,
  5. Helene Faure,
  6. Angele Schoenfelder,
  7. Andre Mann,
  8. Fabrizio Manetti,
  9. Antonio Solinas,
  10. Maurizio Taddei and
  11. Martial Ruat
  1. Signal Transduction and Developmental Neuropharmacology Team, Institut de Neurobiologie Alfred Fessard IFR2118, Laboratoire de Neurobiologie et Développement, Centre National de la Recherche Scientifique, UPR-3294, Gif-sur-Yvette, France (H.R., E.T., T.G., L.V., H.F., M.R.); Laboratoire d'Innovation Thérapeutique, Centre National de la Recherche Scientifique, Unité Mixte de Recherche-7200, Université de Strasbourg, Illkirch, France (A.S., A.M.); and Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Siena, Italy (F.M., A.S., M.T.)
  1. Address correspondence to:
    Martial Ruat, CNRS, UPR-3294, Laboratoire de Neurobiologie et Développement, Institut de Neurobiologie Alfred Fessard IFR2118, Signal Transduction and Developmental Neuropharmacology team, 1 avenue de la Terrasse, F-91198, Gif-sur-Yvette, France. E-mail: ruat{at}inaf.cnrs-gif.fr
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Research ArticleArticle

Identification and Mechanism of Action of the Acylguanidine MRT-83, a Novel Potent Smoothened Antagonist

Hermine Roudaut, Elisabeth Traiffort, Tatiana Gorojankina, Ludwig Vincent, Helene Faure, Angele Schoenfelder, Andre Mann, Fabrizio Manetti, Antonio Solinas, Maurizio Taddei and Martial Ruat
Molecular Pharmacology March 1, 2011, 79 (3) 453-460; DOI: https://doi.org/10.1124/mol.110.069708
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