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Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies β-Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective

Filippo Caraci, Gemma Molinaro, Giuseppe Battaglia, Maria Laura Giuffrida, Barbara Riozzi, Anna Traficante, Valeria Bruno, Milena Cannella, Sara Merlo, Xushan Wang, Beverly A. Heinz, Eric S. Nisenbaum, Thomas C. Britton, Filippo Drago, Maria Angela Sortino, Agata Copani and Ferdinando Nicoletti
Molecular Pharmacology March 2011, 79 (3) 618-626; DOI: https://doi.org/10.1124/mol.110.067488

Article Information

vol. 79 no. 3 618-626
DOI 
https://doi.org/10.1124/mol.110.067488
PubMed 
21159998
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 13, 2010
  • Accepted November 29, 2010
  • Published online February 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Filippo Caraci,
  2. Gemma Molinaro,
  3. Giuseppe Battaglia,
  4. Maria Laura Giuffrida,
  5. Barbara Riozzi,
  6. Anna Traficante,
  7. Valeria Bruno,
  8. Milena Cannella,
  9. Sara Merlo,
  10. Xushan Wang,
  11. Beverly A. Heinz,
  12. Eric S. Nisenbaum,
  13. Thomas C. Britton,
  14. Filippo Drago,
  15. Maria Angela Sortino,
  16. Agata Copani and
  17. Ferdinando Nicoletti
  1. Departments of Pharmaceutical Sciences (F.C., M.L.G., A.C.) and Experimental and Clinical Pharmacology, (S.M., F.D., M.A.S.), University of Catania, Catania, Italy; Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy (G.M., G.B., B.R., A.T., V.B., M.C., F.N.); Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy (M.L.G.); Institute of Biostructure and Bioimaging, National Research Council, Catania, Italy (A.C.); Department of Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy (V.B., F.N.); and Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN (X.W., B.A.H., E.S.N., T.C.B.)
  1. Address correspondence to:
    Ferdinando Nicoletti, Department of Physiology and Pharmacology, University of Rome Sapienza, Piazzale Aldo Moro 6, 00185, Rome, Italy. E-mail: ferdinandonicoletti{at}hotmail.com
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Research ArticleArticle

Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies β-Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective

Filippo Caraci, Gemma Molinaro, Giuseppe Battaglia, Maria Laura Giuffrida, Barbara Riozzi, Anna Traficante, Valeria Bruno, Milena Cannella, Sara Merlo, Xushan Wang, Beverly A. Heinz, Eric S. Nisenbaum, Thomas C. Britton, Filippo Drago, Maria Angela Sortino, Agata Copani and Ferdinando Nicoletti
Molecular Pharmacology March 1, 2011, 79 (3) 618-626; DOI: https://doi.org/10.1124/mol.110.067488
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