Molecular Pharmacology: 88 (6)

December 01, 2015; Volume 88,Issue 6

Commentary

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The Effective Application of Biased Signaling to New Drug Discovery
Terry Kenakin

Molecular Pharmacology December 2015, 88 (6) 1055-1061; DOI: https://doi.org/10.1124/mol.115.099770

Articles

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Identification of an EGFRvIII-JNK2-HGF/c-Met–Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion
Vanessa C. Saunders, Marie Lafitte, Isabel Adrados, Victor Quereda, Daniel Feurstein, YuanYuan Ling, Mohammad Fallahi, Laura H. Rosenberg and Derek R. Duckett

Molecular Pharmacology December 2015, 88 (6) 962-969; DOI: https://doi.org/10.1124/mol.115.097774
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Oxidative Stress and Response to Thymidylate Synthase-Targeted Antimetabolites
Ufuk Ozer, Karen W. Barbour, Sarah A. Clinton and Franklin G. Berger

Molecular Pharmacology December 2015, 88 (6) 970-981; DOI: https://doi.org/10.1124/mol.115.099614
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Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding
Adam J. Stein, Gretchen Bain, Pat Prodanovich, Angelina M. Santini, Janice Darlington, Nina M. P. Stelzer, Ranjinder S. Sidhu, Jeffrey Schaub, Lance Goulet, Dave Lonergan, Imelda Calderon, Jilly F. Evans and John H. Hutchinson

Molecular Pharmacology December 2015, 88 (6) 982-992; DOI: https://doi.org/10.1124/mol.115.100404
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Molecular Basis for Differential Sensitivity of α-Conotoxin RegIIA at Rat and Human Neuronal Nicotinic Acetylcholine Receptors
Shiva N. Kompella, Hartmut Cuny, Andrew Hung and David J. Adams

Molecular Pharmacology December 2015, 88 (6) 993-1001; DOI: https://doi.org/10.1124/mol.115.100503
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Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target Na_V1.7
Julie K. Klint, Yanni K.-Y. Chin and Mehdi Mobli

Molecular Pharmacology December 2015, 88 (6) 1002-1010; DOI: https://doi.org/10.1124/mol.115.100784
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Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity
Nestor O. Concha, Angela Smallwood, William Bonnette, Rachel Totoritis, Guofeng Zhang, Kelly Federowicz, Jingsong Yang, Hongwei Qi, Stephanie Chen, Nino Campobasso, Anthony E. Choudhry, Leanna E. Shuster, Karen A. Evans, Jeff Ralph, Sharon Sweitzer, Dirk A. Heerding, Carolyn A. Buser, Dai-Shi Su and M. Phillip DeYoung

Molecular Pharmacology December 2015, 88 (6) 1011-1023; DOI: https://doi.org/10.1124/mol.115.100917
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Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol–Bound β₁-Adrenergic Receptor
Tomomi Sato, Jillian Baker, Tony Warne, Giles A. Brown, Andrew G.W. Leslie, Miles Congreve and Christopher G. Tate

Molecular Pharmacology December 2015, 88 (6) 1024-1034; DOI: https://doi.org/10.1124/mol.115.101030
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Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula
Pei-Yu Shih, J. Michael McIntosh and Ryan M. Drenan

Molecular Pharmacology December 2015, 88 (6) 1035-1044; DOI: https://doi.org/10.1124/mol.115.101444
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A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity
Rui Xiong, Wenbo Zhou, David Siegel, Russell R. A. Kitson, Curt R. Freed, Christopher J. Moody and David Ross

Molecular Pharmacology December 2015, 88 (6) 1045-1054; DOI: https://doi.org/10.1124/mol.115.101451
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AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition
Hui Lin, Nianshuang Li, Huan He, Ying Ying, Shashank Sunkara, Lingyu Luo, Nonghua Lv, Deqiang Huang and Zhijun Luo

Molecular Pharmacology December 2015, 88 (6) 1062-1071; DOI: https://doi.org/10.1124/mol.115.099549
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An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na⁺/Glucose Cotransporter 1 Gene Expression
Chun-Wen Wang, Shih-Chieh Su, Shu-Fen Huang, Yu-Chuan Huang, Fang-Na Chan, Yu-Han Kuo, Mei-Whey Hung, Hang-Chin Lin, Wen-Liang Chang and Tsu-Chung Chang

Molecular Pharmacology December 2015, 88 (6) 1072-1083; DOI: https://doi.org/10.1124/mol.114.097352
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Impaired Hepatic Uptake by Organic Anion-Transporting Polypeptides Is Associated with Hyperbilirubinemia and Hypercholanemia in Atp11c Mutant Mice
Yusuke Matsuzaka, Hisamitsu Hayashi and Hiroyuki Kusuhara

Molecular Pharmacology December 2015, 88 (6) 1085-1092; DOI: https://doi.org/10.1124/mol.115.100578