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The tricyclic anti-depressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases:in vitro and in silico evidence

Xinliang Mao, Tingjun Hou, Biyin Cao, Wenjie Wang, Zhihua Li, Suning Chen, Min Fei, Rose Hurren, Marcela Gronda, Depei Wu, Suzzane Trudel and Aaron D Schimmer
Molecular Pharmacology January 10, 2011, mol.110.068122; DOI: https://doi.org/10.1124/mol.110.068122

Article Information

mol.110.068122
DOI 
https://doi.org/10.1124/mol.110.068122
PubMed 
21220410
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 12, 2010
  • Revision received December 17, 2010
  • Accepted January 6, 2011
  • Published online January 10, 2011.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xinliang Mao1,*,
  2. Tingjun Hou1,
  3. Biyin Cao1,
  4. Wenjie Wang1,
  5. Zhihua Li2,
  6. Suning Chen1,
  7. Min Fei1,
  8. Rose Hurren2,
  9. Marcela Gronda2,
  10. Depei Wu1,
  11. Suzzane Trudel2 and
  12. Aaron D Schimmer2
  1. 1 Soochow University;
  2. 2 Princess Margaret Hospital
  1. * Corresponding author; email: xinliangmao{at}suda.edu.cn

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The tricyclic anti-depressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases:in vitro and in silico evidence

Xinliang Mao, Tingjun Hou, Biyin Cao, Wenjie Wang, Zhihua Li, Suning Chen, Min Fei, Rose Hurren, Marcela Gronda, Depei Wu, Suzzane Trudel and Aaron D Schimmer
Molecular Pharmacology January 10, 2011, mol.110.068122; DOI: https://doi.org/10.1124/mol.110.068122
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