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History
- Received April 19, 2021
- Accepted January 27, 2022
- Published online March 16, 2022.
Article Versions
- Earlier version (February 3, 2022 - 14:39).
- You are viewing the most recent version of this article.
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U.S. Government work not protected by U.S. copyright.
Author Information
- Pedro Torres-Ayuso and
- John Brognard
- Laboratory of Cell and Developmental Signaling, National Cancer Institute, Center for Cancer Research, Frederick, Maryland
- Address correspondence to
: Pedro Torres-Ayuso, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702. Email: torresayusop2{at}nih.gov; or John Brognard, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702. Email: john.brognard{at}nih.gov
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- Abstract
- Protein Kinase Amplification in Cancer
- Targeted Protein Degradation
- Optimizing PROTAC-Mediated Kinase Degradation: A Windy Road
- PROTACs as Tools to Inform New Cancer Biology
- PROTACs as Anticancer Agents: The Road Ahead
- Conclusions and Future Perspectives
- Acknowledgments
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