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Research ArticleArticle

Exploring the Mechanism of Agonist Efficacy: A Relationship between Efficacy and Agonist Dissociation Rate at the Muscarinic M3 Receptor

David A. Sykes, Mark R. Dowling and Steven J. Charlton
Molecular Pharmacology September 2009, 76 (3) 543-551; DOI: https://doi.org/10.1124/mol.108.054452

Article Information

vol. 76 no. 3 543-551
DOI 
https://doi.org/10.1124/mol.108.054452
PubMed 
19498041
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received December 24, 2008
  • Accepted June 4, 2009
  • Published online August 21, 2009.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David A. Sykes,
  2. Mark R. Dowling, and
  3. Steven J. Charlton
  1. Novartis Institutes for Biomedical Research, Horsham, West Sussex, United Kingdom
  1. Address correspondence to:
    Dr. Steven J. Charlton, Novartis Institutes for Biomedical Sciences, Wimblehurst Road, Horsham, West Sussex, UK. E-mail: steven.charlton{at}novartis.com
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Research ArticleArticle

Exploring the Mechanism of Agonist Efficacy: A Relationship between Efficacy and Agonist Dissociation Rate at the Muscarinic M3 Receptor

David A. Sykes, Mark R. Dowling and Steven J. Charlton
Molecular Pharmacology September 1, 2009, 76 (3) 543-551; DOI: https://doi.org/10.1124/mol.108.054452
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