Research ArticleArticle
Bcrp1;Mdr1a/b;Mrp2 Combination Knockout Mice: Altered Disposition of the Dietary Carcinogen PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) and Its Genotoxic Metabolites
Maria L. H. Vlaming, Sebastiaan F. Teunissen, Evita van de Steeg, Anita van Esch, Els Wagenaar, Luc Brunsveld, Tom F. A. de Greef, Hilde Rosing, Jan H. M. Schellens, Jos H. Beijnen and Alfred H. Schinkel
Molecular Pharmacology March 2014, 85 (3) 520-530; DOI: https://doi.org/10.1124/mol.113.088823
Maria L. H. Vlaming
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Sebastiaan F. Teunissen
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Evita van de Steeg
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Anita van Esch
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Els Wagenaar
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Luc Brunsveld
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Tom F. A. de Greef
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Hilde Rosing
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Jan H. M. Schellens
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Jos H. Beijnen
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
Alfred H. Schinkel
Divisions of Molecular Oncology (M.L.H.V., E.v.d.S., A.v.E., E.W., A.H.S.) and Clinical Pharmacology (J.H.M.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands (S.F.T., H.R., J.H.B.); Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (L.B., T.F.A.d.G.); and Department of Pharmaceutical Sciences, Science Faculty, Utrecht University, Utrecht, The Netherlands (J.H.M.S., J.H.B.)
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Research ArticleArticle
PhIP PK in Bcrp1;Mdr1a/b;Mrp2−/− and Bcrp1;Mrp2;Mrp3−/− Mice
Maria L. H. Vlaming, Sebastiaan F. Teunissen, Evita van de Steeg, Anita van Esch, Els Wagenaar, Luc Brunsveld, Tom F. A. de Greef, Hilde Rosing, Jan H. M. Schellens, Jos H. Beijnen and Alfred H. Schinkel
Molecular Pharmacology March 1, 2014, 85 (3) 520-530; DOI: https://doi.org/10.1124/mol.113.088823
Research ArticleArticle
PhIP PK in Bcrp1;Mdr1a/b;Mrp2−/− and Bcrp1;Mrp2;Mrp3−/− Mice
Maria L. H. Vlaming, Sebastiaan F. Teunissen, Evita van de Steeg, Anita van Esch, Els Wagenaar, Luc Brunsveld, Tom F. A. de Greef, Hilde Rosing, Jan H. M. Schellens, Jos H. Beijnen and Alfred H. Schinkel
Molecular Pharmacology March 1, 2014, 85 (3) 520-530; DOI: https://doi.org/10.1124/mol.113.088823
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