Table of Contents

Articles

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  First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain–Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids

  Xu Liu, Yashuo Wang and Eric A. Ortlund

  Molecular Pharmacology October 2019, 96 (4) 408-417; DOI: https://doi.org/10.1124/mol.119.116806
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  Open Access

  CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

  Smit Kour, Sandeep Rana, Jacob I. Contreras, Hannah M. King, Caroline M. Robb, Yogesh A. Sonawane, Mourad Bendjennat, Ayrianne J. Crawford, Carter J. Barger, Smitha Kizhake, Xu Luo, Michael A. Hollingsworth and Amarnath Natarajan

  Molecular Pharmacology October 2019, 96 (4) 419-429; DOI: https://doi.org/10.1124/mol.119.116855
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  Ligand-Free Estrogen Receptor α (ESR1) as Master Regulator for the Expression of CYP3A4 and Other Cytochrome P450 Enzymes in the Human Liver

  Danxin Wang, Rong Lu, Grzegorz Rempala and Wolfgang Sadee

  Molecular Pharmacology October 2019, 96 (4) 430-440; DOI: https://doi.org/10.1124/mol.119.116897
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  Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G

  Masaki Saito, Linran Cui, Marina Hirano, Guanjie Li, Teruyuki Yanagisawa, Takeya Sato and Jun Sukegawa

  Molecular Pharmacology October 2019, 96 (4) 441-451; DOI: https://doi.org/10.1124/mol.119.116426
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  Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain

  Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein

  Molecular Pharmacology October 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947
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  Calcium-Sensing Receptor Internalization Is β-Arrestin–Dependent and Modulated by Allosteric Ligands

  Iris Mos, Stine E. Jacobsen, Simon R. Foster and Hans Bräuner-Osborne

  Molecular Pharmacology October 2019, 96 (4) 463-474; DOI: https://doi.org/10.1124/mol.119.116772
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  Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations

  Mandeep Atwal, Rebecca L. Swan, Chloe Rowe, Ka C. Lee, David C. Lee, Lyle Armstrong, Ian G. Cowell and Caroline A. Austin

  Molecular Pharmacology October 2019, 96 (4) 475-484; DOI: https://doi.org/10.1124/mol.119.117259
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  Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2

  Xiao Shi, Tracy L. Swanson, Nicholas B. Miner, Amy J. Eshleman and Aaron Janowsky

  Molecular Pharmacology October 2019, 96 (4) 493-504; DOI: https://doi.org/10.1124/mol.119.116798
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  Separation of Acute Desensitization and Long-Term Tolerance of µ-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation

  Seksiri Arttamangkul, Emily R. Leff, Omar Koita, William T. Birdsong and John T. Williams

  Molecular Pharmacology October 2019, 96 (4) 505-514; DOI: https://doi.org/10.1124/mol.119.117358
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  ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel

  Yu-Sheng Wu, Janet Jiang, Saumel Ahmadi, Alexandria Lew, Onofrio Laselva, Sunny Xia, Claire Bartlett, Wan Ip, Leigh Wellhauser, Hong Ouyang, Tanja Gonska, Theo J. Moraes and Christine E. Bear

  Molecular Pharmacology October 2019, 96 (4) 515-525; DOI: https://doi.org/10.1124/mol.119.117143