Table of Contents

Articles

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  Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone

  Yanjun Hong, Yvonne Mei Fen Chia, Ray Hng Yeo, Gopalakrishnan Venkatesan, Siew Kwan Koh, Christina Li Lin Chai, Lei Zhou, Pipin Kojodjojo and Eric Chun Yong Chan

  Molecular Pharmacology January 2016, 89 (1) 1-13; DOI: https://doi.org/10.1124/mol.115.100891
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  The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety

  Sang Jun Han, Khurshida Begum, Charles E. Foulds, Ross A. Hamilton, Suzanna Bailey, Anna Malovannaya, Doug Chan, Jun Qin and Bert W. O’Malley

  Molecular Pharmacology January 2016, 89 (1) 14-26; DOI: https://doi.org/10.1124/mol.115.100925
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  Chronic Oxidative Stress Increases Resistance to Doxorubicin-Induced Cytotoxicity in Renal Carcinoma Cells Potentially Through Epigenetic Mechanism

  Logeswari Ponnusamy, Prathap Kumar S. Mahalingaiah and Kamaleshwar P. Singh

  Molecular Pharmacology January 2016, 89 (1) 27-41; DOI: https://doi.org/10.1124/mol.115.100206
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  Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA₁ and Clinically Used Prostaglandins

  Beatriz Díez-Dacal, Francisco J. Sánchez-Gómez, Pedro A. Sánchez-Murcia, Ivana Milackova, Tahl Zimmerman, Jana Ballekova, Elena García-Martín, José A. G. Agúndez, Severine Gharbi, Federico Gago, Milan Stefek and Dolores Pérez-Sala

  Molecular Pharmacology January 2016, 89 (1) 42-52; DOI: https://doi.org/10.1124/mol.115.100693
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  Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination

  Amelia M. Huehls, Catherine J. Huntoon, Poorval M. Joshi, Carly A. Baehr, Jill M. Wagner, Xiaoxiao Wang, Marietta Y. Lee and Larry M. Karnitz

  Molecular Pharmacology January 2016, 89 (1) 53-62; DOI: https://doi.org/10.1124/mol.115.100164
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  Axon-to-Glia Interaction Regulates GABA_A Receptor Expression in Oligodendrocytes

  Rogelio O. Arellano, María Victoria Sánchez-Gómez, Elena Alberdi, Manuel Canedo-Antelo, Juan Carlos Chara, Aitor Palomino, Alberto Pérez-Samartín and Carlos Matute

  Molecular Pharmacology January 2016, 89 (1) 63-74; DOI: https://doi.org/10.1124/mol.115.100594
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  Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of G_i/o-Coupled G Protein–Coupled Receptors

  Zack Zurawski, Shelagh Rodriguez, Karren Hyde, Simon Alford and Heidi E. Hamm

  Molecular Pharmacology January 2016, 89 (1) 75-83; DOI: https://doi.org/10.1124/mol.115.101600
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  Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia

  Andreia Barateiro, Shujuan Chen, Mei-Fei Yueh, Adelaide Fernandes, Helena Sofia Domingues, João Relvas, Olivier Barbier, Nghia Nguyen, Robert H. Tukey and Dora Brites

  Molecular Pharmacology January 2016, 89 (1) 84-93; DOI: https://doi.org/10.1124/mol.115.098228
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  Interdicting G_q Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms

  Richard Carr, Cynthia Koziol-White, Jie Zhang, Hong Lam, Steven S. An, Gregory G. Tall, Reynold A. Panettieri and Jeffrey L. Benovic

  Molecular Pharmacology January 2016, 89 (1) 94-104; DOI: https://doi.org/10.1124/mol.115.100339
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  A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle

  Justin A. MacDonald, Cindy Sutherland, David A. Carlson, Sabreena Bhaidani, Abdulhameed Al-Ghabkari, Karl Swärd, Timothy A. J. Haystead and Michael P. Walsh

  Molecular Pharmacology January 2016, 89 (1) 105-117; DOI: https://doi.org/10.1124/mol.115.100529
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  Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption

  Maike Veyhl-Wichmann, Alexandra Friedrich, Alexandra Vernaleken, Smriti Singh, Helmut Kipp, Valentin Gorboulev, Thorsten Keller, Chakravarthi Chintalapati, Rüdiger Pipkorn, Marçal Pastor-Anglada, Jürgen Groll and Hermann Koepsell

  Molecular Pharmacology January 2016, 89 (1) 118-132; DOI: https://doi.org/10.1124/mol.115.101162
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  Bumetanide Derivatives AqB007 and AqB011 Selectively Block the Aquaporin-1 Ion Channel Conductance and Slow Cancer Cell Migration

  Mohamad Kourghi, Jinxin V. Pei, Michael L. De Ieso, Gary Flynn and Andrea J. Yool

  Molecular Pharmacology January 2016, 89 (1) 133-140; DOI: https://doi.org/10.1124/mol.115.101618
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  CYP2C8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor α in Human Liver

  Ngome L. Makia and Joyce A. Goldstein

  Molecular Pharmacology January 2016, 89 (1) 154-164; DOI: https://doi.org/10.1124/mol.115.100255
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  Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters

  Walter Sandtner, Thomas Stockner, Peter S. Hasenhuetl, John S. Partilla, Amir Seddik, Yuan-Wei Zhang, Jianjing Cao, Marion Holy, Thomas Steinkellner, Gary Rudnick, Michael H. Baumann, Gerhard F. Ecker, Amy Hauck Newman and Harald H. Sitte

  Molecular Pharmacology January 2016, 89 (1) 165-175; DOI: https://doi.org/10.1124/mol.115.101394
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  Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction

  M. Germana Sanna, Kevin P. Vincent, Emanuela Repetto, Nhan Nguyen, Steven J. Brown, Lusine Abgaryan, Sean W. Riley, Nora B. Leaf, Stuart M. Cahalan, William B. Kiosses, Yasushi Kohno, Joan Heller Brown, Andrew D. McCulloch, Hugh Rosen and Pedro J. Gonzalez-Cabrera

  Molecular Pharmacology January 2016, 89 (1) 176-186; DOI: https://doi.org/10.1124/mol.115.100222
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  Voltage-Gated R-Type Calcium Channel Inhibition via Human μ-, δ-, and κ-opioid Receptors Is Voltage-Independently Mediated by Gβγ Protein Subunits

  Géza Berecki, Leonid Motin and David J. Adams

  Molecular Pharmacology January 2016, 89 (1) 187-196; DOI: https://doi.org/10.1124/mol.115.101154
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  Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor

  Nicole Urban, Liming Wang, Sandra Kwiek, Jörg Rademann, Wolfgang M. Kuebler and Michael Schaefer

  Molecular Pharmacology January 2016, 89 (1) 197-213; DOI: https://doi.org/10.1124/mol.115.100792